Restriction-modification system with methyl-inhibited base excision and abasic-site cleavage activities. [PDF]
Nucleic Acids Res, 2015 The restriction-modification systems use epigenetic modification to distinguish between self and nonself DNA. A modification enzyme transfers a methyl group to a base in a specific DNA sequence while its cognate restriction enzyme introduces breaks in ...
Fukuyo M +9 more
europepmc +6 more sources
The extremophile Picrophilus torridus carries a DNA adenine methylase M.PtoI that is part of a Type I restriction-modification system [PDF]
Frontiers in Microbiology, 2023 DNA methylation events mediated by orphan methyltransferases modulate various cellular processes like replication, repair and transcription. Bacteria and archaea also harbor DNA methyltransferases that are part of restriction-modification systems, which ...
Pallavi Gulati +3 more
doaj +2 more sources
Plasmid pEC156, a Naturally Occurring Escherichia coli Genetic Element That Carries Genes of the EcoVIII Restriction-Modification System, Is Mobilizable among Enterobacteria. [PDF]
PLoS ONE, 2016 Type II restriction-modification systems are ubiquitous in prokaryotes. Some of them are present in naturally occurring plasmids, which may facilitate the spread of these systems in bacterial populations by horizontal gene transfer.
Olesia Werbowy, Tadeusz Kaczorowski
doaj +2 more sources
Low-level expression of the Type II restriction-modification system confers potent bacteriophage resistance in Escherichia coli. [PDF]
DNA Res, 2020 Restriction–modification systems (R–M) are one of the antiviral defense tools used by bacteria, and those of the Type II family are composed of a restriction endonuclease (REase) and a DNA methyltransferase (MTase).
Wilkowska K +3 more
europepmc +2 more sources
The DNA Phosphorothioation Restriction-Modification System Influences the Antimicrobial Resistance of Pathogenic Bacteria [PDF]
Microbiology Spectrum, 2023 Bacterial defense barriers, such as DNA methylation-associated restriction-modification (R-M) and the CRISPR-Cas system, play an important role in bacterial antimicrobial resistance (AMR).
Congrui Xu +9 more
doaj +2 more sources
A novel SfaNI-like restriction-modification system in Caldicellulosiruptor extents the genetic engineering toolbox for this genus [PDF]
PLoS ONE, 2022 Caldicellulosiruptor is a genus of thermophilic to hyper-thermophilic microorganisms that express and secrete an arsenal of enzymes degrading lignocellulosic biomasses into fermentable sugars.
Steve Swinnen +7 more
doaj +3 more sources
The restriction impacts of the Type III restriction-modification system on the transmission dynamics of antimicrobial resistance genes in Campylobacter jejuni [PDF]
Frontiers in MicrobiologyIntroductionThe spread of antibiotic resistance genes among Campylobacter jejuni (C. jejuni) is a serious problem, and the effects of the restriction-modification (R-M) system on the transmission dynamics of these genes in C.
Yu Qiu +5 more
doaj +2 more sources
Type II Restriction-Modification System from Gardnerella vaginalis ATCC 14018 [PDF]
Pathogens, 2020 Intensive horizontal gene transfer may generate diversity and heterogeneity within the genus Gardnerella. Restriction-modification (R-M) systems and CRISPR-Cas are the principal defense tools against foreign DNA in bacteria.
Aistė Bulavaitė +3 more
doaj +2 more sources
A Type I Restriction-Modification System Associated with Enterococcus faecium Subspecies Separation. [PDF]
Appl Environ Microbiol, 2019 Enterococcus faecium is a leading cause of hospital-acquired infections around the world. Rising antibiotic resistance in certain E. faecium lineages leaves fewer treatment options.
Huo W +4 more
europepmc +2 more sources
DNA methylation from a Type I restriction modification system influences gene expression and virulence in Streptococcus pyogenes. [PDF]
PLoS Pathog, 2019 DNA methylation is pervasive across all domains of life. In bacteria, the presence of N6-methyladenosine (m6A) has been detected among diverse species, yet the contribution of m6A to the regulation of gene expression is unclear in many organisms. Here we
Nye TM +6 more
europepmc +2 more sources