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Restriction modification systems as engines of diversity [PDF]
Frontiers in Microbiology, 2015 Restriction modification (RM) systems provide protection against a broad spectrum of phages. However, the likelihood of a phage permanently bypassing this can be as high as 0.1 per infection (Korona et al., 1993) which makes for a relatively weak defense.
Sneppen, Kim +3 more
openaire +4 more sources
Frontiers in Microbiology, 2021 Thermococcus kodakarensis (T. kodakarensis), a hyperthermophilic, genetically accessible model archaeon, encodes two putative restriction modification (R-M) defense systems, TkoI and TkoII.
Kelly M. Zatopek +6 more
doaj +1 more source
Frontiers in Microbiology, 2020 Campylobacter jejuni is a major cause of foodborne gastroenteritis worldwide inflicting palpable socioeconomic costs. The ability of this pathogen to successfully infect its hosts is determined not only by the presence of specific virulence genes but ...
Sandeep Ghatak +3 more
doaj +1 more source
A Type III restriction–modification system in Mycoplasma mycoides subsp. capri [PDF]
Open Biology, 2012 The sequenced genome of Mycoplasma mycoides subsp. capri revealed the presence of a Type III restriction–modification system (MmyCI). The methyltransferase (modification) subunit of MmyCI (M.MmyCI) was shown to recognize the sequence 5′-TGAG-3′ and ...
Mikkel A. Algire +4 more
doaj +1 more source
Frontiers in Cellular and Infection Microbiology, 2022 Anti-restriction proteins are typically encoded by plasmids, conjugative transposons, or phages to improve their chances of entering a new bacterial host with a type I DNA restriction and modification (RM) system.
Huimin Chen +6 more
doaj +1 more source
Pathological phenotypes and in vivo DNA cleavage by unrestrained activity of a phosphorothioate-based restriction system in Salmonella [PDF]
, 2014 Prokaryotes protect their genomes from foreign DNA with a diversity of defence mechanisms, including a widespread restriction–modification (R–M) system involving phosphorothioate (PT) modification of the DNA backbone. Unlike classical R–M systems, highly
Cao, Bo +8 more
core +1 more source
BMC Microbiology, 2008 Background Many microbes possess restriction-modification systems that protect them from parasitic DNA molecules. Unfortunately, the presence of a restriction-modification system in a given microbe also hampers genetic analysis.
Ward Jordan D +3 more
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Transcription regulation of the EcoRV restriction-modification system [PDF]
Nucleic Acids Research, 2005 When a plasmid containing restriction-modification (R-M) genes enters a naïve host, unmodified host DNA can be destroyed by restriction endonuclease. Therefore, expression of R-M genes must be regulated to ensure that enough methyltransferase is produced and that host DNA is methylated before the endonuclease synthesis begins.
Semenova, Ekaterina +8 more
openaire +2 more sources
Phase variation of a Type IIG restriction-modification enzyme alters site-specific methylation patterns and gene expression in Campylobacter jejuni strain NCTC11168 [PDF]
, 2016 Phase-variable restriction-modification systems are a feature of a diverse range of bacterial species. Stochastic, reversible switches in expression of the methyltransferase produces variation in methylation of specific sequences.
Awais Anjum +13 more
core +2 more sources
Methylome-dependent transformation of emm1 group A streptococci
mBio, 2023 Genetic intractability presents a fundamental barrier to the manipulation of bacteria, hindering advancements in microbiological research. Group A Streptococcus (GAS), a lethal human pathogen currently associated with an unprecedented surge of infections
Joana Alves +4 more
doaj +1 more source