Results 71 to 80 of about 18,457,999 (286)

Broadness and specificity: ArdB, ArdA, and Ocr against various restriction-modification systems

Frontiers in Microbiology, 2023
ArdB, ArdA, and Ocr proteins inhibit the endonuclease activity of the type I restriction-modification enzymes (RMI). In this study, we evaluated the ability of ArdB, ArdA, and Ocr to inhibit different subtypes of Escherichia coli RMI systems (IA, IB, and
Anna A. Kudryavtseva, Eva Cséfalvay, Evgeniy Yu Gnuchikh, Darya D. Yanovskaya, Mikhail A. Skutel, Artem B. Isaev, Sergey V. Bazhenov, Sergey V. Bazhenov, Sergey V. Bazhenov, Anna A. Utkina, Ilya V. Manukhov, Ilya V. Manukhov, Ilya V. Manukhov   +12 more
doaj   +1 more source

Central Nervous System Tumors Among Infants in Canada: A Report From CYP‐C

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) tumors in infants are rare, pose unique clinical challenges, and lack large‐scale evidence‐based data to guide management. This study seeks to describe CNS tumors in Canadian infants and to compare their outcomes with those of older children.
Samuel Sassine, Hallie Coltin, Sylvia Cheng, Lucie Lafay‐Cousin, Vanan Issai Magimairajan, Craig Erker, Stéphanie Vairy, Lynette Bowes, Adam Fleming, Donna Johnston, Sarah McKillop, Roona Sinha, Julie Bennett, Christina Coleman, Laura Wheaton, Shayna Zelcer, Samuele Renzi, Thai Hoa Tran   +17 more
wiley   +1 more source

BsuMI regulates DNA transformation in Bacillus subtilis besides the defense system and the constructed strain with BsuMI-absence is applicable as a universal transformation platform for wild-type Bacillus

Microbial Cell Factories
Background To effectively introduce plasmids into Bacillus species and conduct genetic manipulations in Bacillus chassis strains, it is essential to optimize transformation methods.
Zhao Xingya, Fu Xiaoping, Zhen Jie, Yang Jun, Zheng Hongchen, Bai Wenqin, Song Hui   +6 more
doaj   +1 more source

Comparative Drug Response Profiling in Neuroblastoma Cell Lines and Patient‐Derived Tumor Organoids

Pediatric Blood &Cancer, EarlyView.
ABSTRACT High‐risk neuroblastoma remains a leading cause of pediatric cancer mortality, and improved preclinical models are needed to guide therapeutic developments. We screened seven high‐risk neuroblastoma cell lines and three patient‐derived tumor organoids with 528 compounds alongside bone marrow controls, and compared them with external datasets ...
Krzysztof Wierbiłowicz, Se Whee Sammy Park, Aironas Los, Ernest Liu, Nona Struyf, Tom Erkers, Sören Lehmann, Jan J. Molenaar, Jakob Stenman, Olli Kallioniemi, Päivi Östling, Brinton Seashore‐Ludlow, Kasper Karlsson   +12 more
wiley   +1 more source

A genetic dissection of the LlaJI restriction cassette reveals insights on a novel bacteriophage resistance system

BMC Microbiology, 2006
Background Restriction/modification systems provide the dual function of protecting host DNA against restriction by methylation of appropriate bases within their recognition sequences, and restriction of foreign invading un-methylated DNA, such as ...
Fitzgerald Gerald F, Wilson Geoffrey G, Heiter Daniel F, O'Driscoll Jonathan, Roberts Richard, Sinderen Douwe van   +5 more
doaj   +1 more source

Evolutionary genome engineering using a restriction–modification system [PDF]

Nucleic Acids Research, 2011
Modification of complex microbial cellular processes is often necessary to obtain organisms with particularly favorable characteristics, but such experiments can take many generations to achieve. In the present article, we accelerated the experimental evolution of Escherichia coli populations under selection for improved growth using one of the ...
Asakura, Yoko, Kojima, Hiroyuki, Kobayashi, Ichizo   +2 more
openaire   +2 more sources

Fourier restriction to polynomial curves I: a geometric inequality [PDF]

, 2010
We prove a Fourier restriction result for general polynomial curves in Rd. Measuring the Fourier restriction with respect to the affine arclength measure of the curve, we obtain a universal estimate for the class of all polynomial curves of bounded ...
Wright, James, Wright, J., null Spyridon Dendrinos, null James Wright, Dendrinos, Spyridon, Dendrinos, S.   +5 more
core   +1 more source

Restriction-modification systems of M. gallisepticum S6.

, 2022
Arrows represent the ORFs; grey, blue, green, and orange colors indicate genes hsdC (controller protein), hsdM (methyltransferase), hsdS (specificity subunit), and hsdR (restriction subunit), respectively. Ori–origin of replication.
Vadim M. Govorun (213423), Alexander A. Arzamasov (14160029), Daria V. Evsyutina (9096071), Valentina G. Ladygina (9096068), Gleb Y. Fisunov (213389), Daria S. Matyushkina (8783387), Irina A. Garanina (14160032), Tatiana A. Semashko (9645302), Olga V. Pobeguts (8497305)   +8 more
core   +1 more source

Impact of Radiation Therapy on Physical and Psychosocial Health of Adolescents and Young Adults: A Joint Report From the Children's Oncology Group AYA and Radiation Oncology Committees

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Rates of cancer among adolescents and young adults (AYA), age 15–39 years, are increasing. Consequently, radiation oncologists are treating more AYAs who have diagnoses spanning both pediatric and adult practices. Compared to pediatric and older adult patients, AYAs face a unique set of challenges.
Hesham Elhalawani, Rachel K. Peterson, Avani D. Rao, Laurie J. McKenzie, Ahmed Magdy Elmotayam, Leslie Chang, Michael Roth, Susan L. McGovern   +7 more
wiley   +1 more source

Comparative analysis of Borrelia’s Defence mechanisms and their impact on genetic manipulation of low-passage isolates of Borrelia afzelii and Borrelia garinii

Current Research in Microbial Sciences
Borrelia, a highly prevalent tick-borne pathogen, has a genome with a linear chromosome and numerous linear and circular plasmids. There are three groups of Borrelia: Lyme borreliosis, relapsing fever, and Echidna-reptile. In Europe, Borrelia afzelii and
Margarida Ruivo, Anna-Margarita Schötta, Theresa Stelzer, Michael Reiter, Michiel Wijnveld   +4 more
doaj   +1 more source