Results 101 to 110 of about 728,418 (291)

The interplay of restriction-modification systems with mobile genetic elements and their prokaryotic hosts

Nucleic Acids Research, 2014
The roles of restriction-modification (R-M) systems in providing immunity against horizontal gene transfer (HGT) and in stabilizing mobile genetic elements (MGEs) have been much debated.
P. Oliveira, M. Touchon, E. Rocha
semanticscholar   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Putative H. parasuis Nagasaki restriction modification systems.

, 2018
Putative H. parasuis Nagasaki restriction modification systems.
Sarah M. Shore (443720), Brian W. Brunelle (376929), Darrell O. Bayles (214795), David P. Alt (4959304), Tracy L. Nicholson (120395)   +4 more
core   +1 more source

Pangenome analysis of Bifidobacterium longum and site-directed mutagenesis through by-pass of restriction-modification systems

BMC Genomics, 2015
Bifidobacterial genome analysis has provided insights as to how these gut commensals adapt to and persist in the human GIT, while also revealing genetic diversity among members of a given bifidobacterial (sub)species.
A. O’Callaghan, Francesca Bottacini, M. Motherway, D. Sinderen   +3 more
semanticscholar   +1 more source

Regulation of gene expression in restriction-modification system Eco29kI [PDF]

Nucleic Acids Research, 2011
The Eco29kI restriction-modification (R-M) system consists of two partially overlapping genes, eco29kIR, encoding a restriction endonuclease and eco29kIM, encoding methyltransferase. The two genes are thought to form an operon with the eco29kIR gene preceding the eco29kIM gene.
Nagornykh, Maxim, Zakharova, Marina, Protsenko, Alexey, Bogdanova, Ekaterina, Solonin, Alexander S., Severinov, Konstantin   +5 more
openaire   +2 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Effects of Population Dynamics on Establishment of a Restriction-Modification System in a Bacterial Host

Molecules, 2019
In vivo dynamics of protein levels in bacterial cells depend on both intracellular regulation and relevant population dynamics. Such population dynamics effects, e.g., interplay between cell and plasmid division rates, are, however, often neglected in ...
Stefan Graovac, Andjela Rodic, Magdalena Djordjevic, Konstantin Severinov, Marko Djordjevic   +4 more
doaj   +1 more source

Burkholderia pseudomallei sequencing identifies genomic clades with distinct recombination, accessory, and epigenetic profiles.

, 2014
Burkholderia pseudomallei (Bp) is the causative agent of the infectious disease melioidosis. To investigate population diversity, recombination, and horizontal gene transfer in closely related Bp isolates, we performed whole-genome sequencing (WGS) on ...
Studholme, David J., Holden, Mathew TG, Ong, C, Beacham, I, Parkhill, J, Harting, J, Chen, Swaine L., Mehershahi, K, Holden, Matthew T. G., Nandi, T, T.G. Holden, Matthew, Didelot, X, Peak, I, Baybayan, Primo, Peak, Ian, Sim, B, Hoon, CH, Nandi, Tannistha, Boddey, J, Boddey, Justin, Boddey, Justin A., Holden, Matthew, J. Studholme, David, Baybayan, P, Michell, S, Essex-Lopresti, AE, Guo, Yan, Sim, Bernice, Didelot, Xavier, Titball, Richard W., Chen, SL, Smither, Sophie, Smiters, Sophie, Beacham, Ifor, Holden, Matthew TG, Smither, S, How, LC, Nelson, Michelle, Ong, Catherine, Tan, P, Wang, S, Aw, LT, Nelson, M, Mitchell, Stephen, Michell, Stephen, Aw, Lay Tin, E. Essex-Lopresti, Angela, Chen, Swaine, Chen, Swaine L, Titball, Richard, Mehrashahi, Kurosh, Hoon, Chua Hui, Boddey, Justin A, Sarkar-Tyson, M, Parkhill, Julian, Mehershahi, Kurosh, Guo, Y, Tan, Patrick, How, Lee Chee, W. Titball, Richard, Sarkar-Tyson, Mitali, Wang, Susana, Essex-Lopresti, Angela, Studholme, David J, Harting, John   +64 more
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Cloning and characterization of theMbollrestriction-modification system

Nucleic Acids Research, 1991
The two genes encoding the class IIS restriction-modification system MboII from Moraxella bovis were cloned separately in two compatible plasmids and expressed in E. coli RR1 delta M15. The nucleotide sequences of the MboII endonuclease (R.MboII) and methylase (M.MboII) genes were determined and the putative start codon of R.MboII was confirmed by ...
H, Bocklage, K, Heeger, B, Müller-Hill
openaire   +3 more sources