Results 81 to 90 of about 728,418 (291)
mSphere, 2016 Enterococcus faecalis is an opportunistic pathogen and a leading cause of nosocomial infections. Conjugative pheromone-responsive plasmids are narrow-host-range mobile genetic elements (MGEs) that are rapid disseminators of antibiotic resistance in the ...
Valerie J. Price +3 more
doaj +1 more source
REMP software to introduce a screening REstriction site in site-directed Mutagenesis Primer
SoftwareX, 2021 Insertion of silent mutations allowing for restriction site modification aids in the screening of successful mutants during site directed mutagenesis. Introducing a new restriction site requires the analysis of degenerate sequences within mutant primer ...
Madhavi Latha Yadav Bangaru, PhD +3 more
doaj +1 more source
Beyond Restriction Modification: Epigenomic Roles of DNA Methylation in Prokaryotes.
Annual Review of Microbiology, 2021 The amount of bacterial and archaeal genome sequence and methylome data has greatly increased over the last decade, enabling new insights into the functional roles of DNA methylation in these organisms.
Brian P. Anton, R. Roberts
semanticscholar +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Central nervous system (CNS) involvement in childhood acute lymphoblastic leukemia (ALL) is assessed by cell counting and cytomorphology from cerebrospinal fluid (CSF) and is used for treatment stratification worldwide. The ratio of “CNS2” patients in clinical trials ranges from 3% to 40%, with unclear prognostic significance ...
Laura Almási +14 more
wiley +1 more source
Applied and Environmental MicrobiologyCo-evolution of bacterial defense systems and phage counter-defense mechanisms has resulted in an intricate biological interplay between bacteriophages and their prey.
David Brandt +10 more
doaj +1 more source
Nucleic Acids Research, 2022 Epigenetic DNA methylation plays an important role in bacteria by influencing gene expression and allowing discrimination between self-DNA and intruders such as phages and plasmids. Restriction–modification (RM) systems use a methyltransferase (MTase) to
N. Birkholz +3 more
semanticscholar +1 more source
The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli +3 more
wiley +1 more source
Vibrio cholerae pathogenicity island 2 encodes two distinct types of restriction systems
In response to predation by bacteriophages and invasion by other mobile genetic elements such as plasmids, bacteria have evolved specialized defense systems that are often clustered together on genomic islands.
Vizzarro, Grazia +3 more
core +2 more sources
Nudeotide sequence of the BsuRI restriction-modification system
Nucleic Acids Research, 1985 The genes of the 5'-GGCC specific BsuRI restriction-modification system of Bacillus subtilis have been cloned and expressed in E. coli and their nucleotide sequence has been determined. The restriction and modification genes code for polypeptides with calculated molecular weights of 66,314 and 49,642, respectively.
A, Kiss +4 more
openaire +3 more sources
Restriction–modification systems and bacteriophage invasion: Who wins? [PDF]
Journal of Theoretical Biology, 2010 The success of a phage that infects a bacterial cell possessing a restriction-modification (R-M) system depends on the activities of the host methyltransferase and restriction endonuclease, and the number of susceptible sites in the phage genome. However, there is no model describing this dependency and linking it to observable parameters such as the ...
Enikeeva, Farida N. +2 more
openaire +2 more sources