Results 221 to 230 of about 15,555 (263)

Tissue‐Specific Extraction and Structural Elucidation of Actin‐Tropomyosin‐Myosin Complexes from Human and Rodent

Aggregate, Volume 7, Issue 1, January 2026.
We developed a general tissue‐extraction strategy that directly purifies native F‐actin and actin–tropomyosin–myosin (ATM) complexes from human and rodent muscles for cryo‐EM. Near‐atomic structures, including an HCM R404Q mouse model, reveal how a disease myosin mutation remodels ATM assembly and alters myosin conformation at the actin interface ...
Danni Li, Qinyue Zhao, Youqi Tao, Shiran Lv, Wanbing Zhao, Yunxia Li, Xingyu Xiong, Zhizhi Wang, Wenqing Xu, Yaoyang Zhang, Cong Liu, Weidong Le, Wenyan Kang, Dan Li, Qin Cao, Bin Dai   +15 more
wiley   +1 more source

First Detection of 1p36 Deletion by Whole‐Exome Sequencing in a Tunisian Patient

Birth Defects Research, Volume 118, Issue 1, January 2026.
ABSTRACT Study Objective We reported a rare case of 1p36 deletion syndrome diagnosed using whole‐exome sequencing (WES) in a Tunisian neonate, and to highlight the utility of WES in detecting structural variants, particularly in resource‐limited settings.
Nesrine Kerkeni, Maher Kharrat, Lilia Kraoua, Ahlem Achour, Faouzi Maazoul, Ridha Mrad, Mediha Trabelsi   +6 more
wiley   +1 more source

Fabp5 Is the Key Regulator Mediating γ‐CEHC Differentiation in Osteoblasts and Osteoclasts

BioFactors, Volume 52, Issue 1, January/February 2026.
γ‐CEHC, as a natural Fabp5 inhibitor, ameliorates the osteoporotic microenvironment through a triple‐action mechanism—targeting Fabp5 inhibition → modulating macrophage polarization → balancing bone metabolism—highlighting its translational medical value.
Cheng Cheng, Rong Chen, Minjuan Li, Shuai Lu, Xinping Li, Gengli Cui, Hailing Chen, Xieyuan Jiang   +7 more
wiley   +1 more source

Comment on “The Crucial Role of Physical Activity Index in Predicting the Incidence of Pacemaker Syndrome”

Journal of Arrhythmia, Volume 42, Issue 1, February 2026.
Ahmet Yılmaz
wiley   +1 more source

Advances and Applications of Spatial Proteomics: From Organellar Maps to Clinical Translation

ChemBioChem, Volume 27, Issue 1, January 2026.
Spatial proteomics provides high‐resolution maps of protein localization and trafficking by combining advanced mass spectrometry with complementary imaging and computational tools. Emerging low‐input and automated workflows are expanding its applicability to challenging clinical samples, supporting mechanistic disease research and biomarker discovery ...
Chiara Bernardini, Maike Däther, Franziska R. Traube   +2 more
wiley   +1 more source

Impaired Relaxation in Induced Pluripotent Stem Cell-Derived Cardiomyocytes with Pathogenic TNNI3 Mutation of Pediatric Restrictive Cardiomyopathy. [PDF]

J Am Heart Assoc
Wang R, Hasegawa M, Suginobe H, Yoshihara C, Ishii Y, Ueyama A, Ueda K, Hashimoto K, Hirose M, Ishii R, Narita J, Watanabe T, Kawamura T, Taira M, Ueno T, Miyagawa S, Ishida H.   +16 more
europepmc   +1 more source

Recurrent Spontaneous Coronary Dissection in Puerperium Precipitating in Cardiogenic Shock Prompted Coronary Artery Bypass Grafting

Clinical Case Reports, Volume 14, Issue 1, January 2026.
Graphical summary of postpartum SCAD: (A) ECG with ST‐elevation; (B) surgical revascularization with BIMA and saphenous vein grafts; (C–D) coronary angiography showing RCA and LAD dissection; (E–F) intraoperative subepicardial hematoma of LM and LCx. ABSTRACT This case report details a rare instance of recurrent spontaneous coronary artery dissection ...
Lorenzo Giovannico, Giuseppe Fischetti, Domenico Parigino, Federica Mazzone, Luca Savino, Emanuela De Cillis, Aldo Domenico Milano, Tomaso Bottio   +7 more
wiley   +1 more source

Euglycemic Ketoacidosis Induced by Dapagliflozin in a Non‐Diabetic Patient With Cardiac Amyloidosis

Clinical Case Reports, Volume 14, Issue 1, January 2026.
ABSTRACT Dapagliflozin, though beneficial in heart failure, can rarely cause euglycemic ketoacidosis even in non‐diabetic patients. Clinicians should maintain a high index of suspicion for metabolic acidosis in patients on SGLT2 inhibitors presenting with unexplained illness, regardless of blood glucose level.
Salhamoud Abdelfatah Saleh Hamoud, Ellie Harding   +1 more
wiley   +1 more source

Cardiac magnetic resonance feature tracking derived left atrial strain in the diagnosis of patients with constrictive pericarditis and restrictive cardiomyopathy. [PDF]

Heliyon
Bo K, Zhao Y, Gao X, Chen Y, Ren Y, Gao Y, Zhou Z, Wang H, Xu L.   +8 more
europepmc   +1 more source