Results 41 to 50 of about 259,600 (261)

APPROACH TO THE COMMERCIALIZATION OF UNIVERSITY’S RESEARCH ON THE BASES OF SPIN-OFF COMPANIES’ CREATION

Вісник: Київський інститут бізнесу та технологій, 2019
The article covers the theoretical approaches to the definition of the “academic spin-offs” concept, substantiates the need for the development of organizational forms of small innovative entrepreneurship in a university environment.
K. Kaschuck, I. Klimova
doaj   +1 more source

Student practical work on the theory of systematic gradual development of intellectual activity of P.Ya. Galperin [PDF]

Национальный психологический журнал, 2017
The paper is devoted to the analysis of student practical work on the theory of systematic gradual development of human intellectual activity, i.e. the fundamental psychological theory of P. Galperin.
Natalia N. Poskrebysheva
doaj   +1 more source

The Format of the Result of Intellectual Activity as an Emerging Object of Intellectual Rights

Actual Problems of Russian Law, 2019
The article investigates the tendency of “formatization” of the results of intellectual activity that is also taking place in cross-border private law relations. On the basis of the analysis of foreign and Russian legal doctrines, jurisprudence and case law, the author comes to the conclusion about the independence of the format as a result of ...
openaire   +2 more sources

On the balance of interests of right holders to official results of intellectual activity

Proceedings of the All-Russian Scientific Conference on Achievements of Science and Technology (DNiT-2021), 2021
This article discusses the main features of the legal regime of service results of intellectual activity. The authors come to the conclusion that it is necessary to legislate the minimum amount of remuneration for the creation of official results of intellectual activity.
Vlada V. Kasulina, Ilya Yu. Martynenko
openaire   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Methodology for evaluating the functional obsolescence of intellectual property objects based on statistical indicators

Интеллект. Инновации. Инвестиции, 2022
The article proposes a methodology for assessing the functional obsolescence of intellectual property objects based on the use of statistical indicators of the results of intellectual activity.
A. V. Lapin, E. N. Mityushkina
doaj   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

ECONOMICAL AND LEGAL CONTROL OF TURNOVER OF RESULTS OF INTELLECTUAL ACTIVITY OF RUSSIAN INDUSTRIAL ENTERPRISES

Статистика и экономика, 2016
The article considers valid principles, primary tasks, most importance factors and conditions (limitations), perspective system model and actual mechanisms of effective economic-legal control of intellectual work results turnover of Russian industrial ...
Dmitriy A. Lovtsov, Marina V. Bogdanova
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source