Results 51 to 60 of about 259,600 (261)

The concept and features of Internet advertising as a result of intellectual activity

Право и политика, 2022
In the era of digitalization, attracting attention to goods, works and services on the Internet is becoming increasingly difficult. In this regard, Internet advertising is becoming more creative, which may indicate that it should be considered as a result of intellectual activity.
openaire   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Problems of management of rights to the results of intellectual activity created using budget funds

Ekonomika Nauki, 2019
The article analyzes the problems arising from the commercialization of scientific results obtained using budgetary funds, due to the unresolved number of fundamental issues of managing the rights to such results of intellectual activity.
D. P. Fedulkin, V. G. Zinov
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Investment activity in intellectual property objects and their use elementary assessment in the company’s activities

Ученые записки Российской академии предпринимательства
The article examines the current trends of investment activity in intellectual property objects. The criteria for recognizing the results of intellectual activity as part of the intangible assets of the enterprise are defined.
S. A. Polukhina, E. A. Nikiforova
doaj   +1 more source

Effective methods of protection of the intellectual activity results in infosphere of global telematics networks

Открытое образование (Москва), 2016
The purpose of this article is perfection of using metodology of technological and organization and legal protect of intellectual activity results and related intellectual rights in information sphere of Global Telematics Networks (such as of «Internet»,
D. A. Lovtsov
doaj   +1 more source

Association between the frequency of daily intellectual activities and cognitive domains: A cross‐sectional study in older adults with complaints of forgetfulness

Brain and Behavior, 2021
Objectives Frequent engagement in intellectual activities has been shown to reduce the risk of developing dementia. The present study sought to examine the association between the frequency of daily intellectual activities and cognitive domains in older ...
Ai Iizuka, Hiroyuki Suzuki, Susumu Ogawa, Tomoya Takahashi, Sachiko Murayama, Momoko Kobayashi, Yoshinori Fujiwara   +6 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Legal Regime of AI-Generated Outputs

Цифровое право
The article is devoted to the study of the legal nature of generative artificial intelligence and its impact on copyright. It examines the features of generative artificial intelligence, which is capable of creating new content in response to user ...
M. V. Samartseva
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source