Results 61 to 70 of about 259,600 (261)

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

PROBLEMS OF INHERITANCE OF INTELLECTUAL RIGHTS TO THE RESULTS OF CREATIVE ACTIVITY AND EQUIVALENT OBJECTS

Гуманитарные и юридические исследования, 2021
In connection with the special nature of intellectual rights to the results of creative activity and objects equated to them, there are certain features of their transition in the order of inheritance, as well as registration of the rights of heirs, not ...
Marina Melnikova, Viktoriia Savina
doaj  

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Legal features of stimulation of innovations in enterprise

Ученые записки Казанского университета: Серия Гуманитарные науки, 2018
The paper substantiates various legal approaches to systemic stimulation of innovations created not only to expand the scope of economic turnover, but also to improve academic science and its relationship with business entities.
O.V. Sushkova
doaj  

Legal Nature of the Website Development Contract as a Result of Intellectual Activity

Vestnik Povolzhskogo instituta upravleniya, 2020
Scientific views of civil scientists and the judicial practice regarding the subject matter of a website development contract. Special attention is paid to the features of a website as a composite and complex result of intellectual activity.
S.N. Mayorov, V.V. Levochko
openaire   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Physical Activity in People with Intellectual Disability: A Narrative Review

مجله پژوهش در علوم توانبخشی, 2019
Introduction: The levels of physical activity and exercise are two important factors to improve health in people with intellectual disability. Several studies addressed the level of physical activity, and the benefits, cautions, and principles of ...
Javid Mostamand, Hamzeh Baharlouei
doaj   +1 more source

[Commercialization of results of intellectual activities in pharmaceutical industry].

Likars'ka sprava, 2003
An analysis has been done of those causes impending the development of innovative processes and commercialization of results of intellectual activities in the economics of Ukraine and its pharmaceutical sector. Possible ways for rectifying the prevailing situation are considered.
O V, Posylkina, V N, Timaniuk, E V, Gladukh   +2 more
openaire   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source