Results 81 to 90 of about 1,185,484 (304)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Legal Regime of AI-Generated Outputs

Цифровое право
The article is devoted to the study of the legal nature of generative artificial intelligence and its impact on copyright. It examines the features of generative artificial intelligence, which is capable of creating new content in response to user ...
M. V. Samartseva
doaj   +1 more source

Promotion of Intellectual Activity Results of Scientific Organizations. Value Estimation

Science Management: Theory and Practice
We consider approaches to assessing the value of intellectual activity results (IAR) from the points of view of the seller and the buyer. The analysis was carried out on the basis of a comparison of the total costs of implementing IAR in which the purchase of a license may be only a part of the costs.
Irina Ganieva, Gennady Shepelev
openaire   +1 more source

The motivating operation and negatively reinforced problem behavior. A systematic review. [PDF]

, 2014
The concept of motivational operations exerts an increasing influence on the understanding and assessment of problem behavior in people with intellectual and developmental disability. In this systematic review of 59 methodologically robust studies of the
Borthwick-Duffy S. A., Carey Y. A., Edrisinha C. E., Kennedy C. H., Miltenberger R. G., Oliver C., Rusch R. G., Scotti J. R.   +7 more
core   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

The Format of the Result of Intellectual Activity as an Emerging Object of Intellectual Rights

Actual Problems of Russian Law, 2019
The article investigates the tendency of “formatization” of the results of intellectual activity that is also taking place in cross-border private law relations. On the basis of the analysis of foreign and Russian legal doctrines, jurisprudence and case law, the author comes to the conclusion about the independence of the format as a result of ...
openaire   +2 more sources

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

PROBLEMS OF INHERITANCE OF INTELLECTUAL RIGHTS TO THE RESULTS OF CREATIVE ACTIVITY AND EQUIVALENT OBJECTS

Гуманитарные и юридические исследования, 2021
In connection with the special nature of intellectual rights to the results of creative activity and objects equated to them, there are certain features of their transition in the order of inheritance, as well as registration of the rights of heirs, not ...
Marina Melnikova, Viktoriia Savina
doaj  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

INTELLECTUAL CAPITAL COMPONENTS AS CAUSES OF REGIONAL DISPARITIES. A CASE STUDY IN ROMANIA [PDF]

Starting from a Logit model developed in the past we try to provide empirical support for counties disparities regarding intellectual capital factor influence. The study presents some correlation between economic performance, structure of activity in the
Alexandru Isaic-Maniu, Bogdan-Vasile Ileanu, Claudiu Herteliu   +2 more
core