Results 111 to 120 of about 1,746 (192)

Quantitative proteomic analysis of aqueous humor from patients with drusen and reticular pseudodrusen in age-related macular degeneration

BMC Ophthalmology, 2018
Background To identify novel biomarkers related to the pathogenesis of dry age-related macular degeneration (AMD), we adopted a human retinal pigment epithelial (RPE) cell culture model that mimics some features of dry AMD including the accumulation of ...
Je-Hyun Baek, Daehan Lim, Kyu Hyung Park, Jae-Byoung Chae, Hyoik Jang, Jonghyun Lee, Hyewon Chung   +6 more
doaj   +1 more source

Accuracy of fundus autofluorescence imaging for the diagnosis and monitoring of retinal conditions: a systematic review

BackgroundNatural fluorescence in the eye may be increased or decreased by diseases that affect theretina. Imaging methods based on confocal scanning laser ophthalmoscopy (cSLO) can detect this ‘fundusautofluorescence’ (FAF) by illuminating the retina ...
Colquitt, Jillian, Frampton, Geoff, Kalita, Neelam, Loveman, Emma, Payne, Elizabeth   +4 more
core   +1 more source

Reticular Pseudodrusen [PDF]

Ophthalmology, 2014
Robert P. Finger, Zhichao Wu, Chi D. Luu, Frances Kearney, Lauren N. Ayton, Lucia M. Lucci, William C. Hubbard, Jill L. Hageman, Gregory S. Hageman, Robyn H. Guymer   +9 more
openaire   +1 more source

Subretinal pigment epithelial deposition of Drusen components including hydroxyapatite in a primary cell culture model [PDF]

, 2016
Purpose: Extracellular deposits containing hydroxyapatite, lipids, proteins, and trace metals that form between the basal lamina of the RPE and the inner collagenous layer of Bruch's membrane are hallmarks of early AMD.
Curcio, CA, Emri, E, Fearn, S, Guidry, C, Knowles, JC, Lanzirotti, A, Lengyel, I, Messinger, JD, Newville, M, Pilgrim, MG, Read, RW   +10 more
core   +1 more source

Reticular pseudodrusen characterization by retromode imaging [PDF]

Acta Ophthalmologica, 2016
Parravano M., Querques L., Boninfante A., Giorno P., Varano M., Bandello F., Querques G.   +6 more
openaire   +2 more sources

Distinct Pathogenic Mechanisms of Neurodegeneration in Pachychoroid Pigment Epitheliopathy Versus Intermediate Age-Related Macular Degeneration

Ophthalmology and Therapy
Introduction To investigate distinct neurodegeneration mechanisms in pachychoroid pigment epitheliopathy (PPE) versus age-related macular degeneration (AMD) using quantitative optical coherence tomography (OCT) with age-matched controls.
Pasquale Viggiano, Lorenzo Accurso Tagano, Roberta Binetti, Stefania De Leonardis, Marco Carella, Giulia Ribezzi, Alba Chiara Termite, Maria Grazia Pignataro, Stefano Dore, Federica Evangelista, Paolo Evangelista, Cristiana Iaculli, Giovanni Alessio, Francesco Boscia   +13 more
doaj   +1 more source

Intergrader Agreement in Grading Optical Coherence Tomography Morphologic Features in Eyes With Intermediate Nonexudative Age-Related Macular Degeneration. [PDF]

PURPOSE: To determine the reliability of a nine-point summary scale for grading intermediate age-related macular degeneration (AMD) image morphologic features based on the Early Treatment Diabetic Retinopathy Study (ETDRS) grid.
Carvajal, Nicole, Kedia, Anjani, Keenan, Jeremy, Nava, Kiana, Stewart, Jay, Yang, Daphne, Yiu, Glenn   +6 more
core   +1 more source

A semi-automated pipeline for quantifying drusen-like deposits in human induced pluripotent stem cell-derived retinal pigment epithelium cells

SLAS Technology
Age-Related Macular Degeneration (AMD) is a highly prevalent form of retinal disease amongst Western communities over 50 years of age. A hallmark of AMD pathogenesis is the accumulation of drusen underneath the retinal pigment epithelium (RPE), a ...
Jenna Hall, Maciej Daniszewski, Shane Cheung, Kalyan Shobhana, Himeesh Kumar, Helena H Liang, Henry Beetham, Ellie Cho, Carla Abbott, Alex W Hewitt, Kaylene J Simpson, Robyn H Guymer, Daniel Paull, Alice Pébay, Grace E. Lidgerwood   +14 more
doaj   +1 more source

Deep Learning and Genome-Wide Analysis of the UK Biobank to Unravel Novel Pathways and Reticular Pseudodrusen’s Role in Age-Related Macular Degeneration [PDF]

Background: Age-related macular degeneration (AMD, the leading cause of vision loss in the Western world, is characterised by drusen, the prototypical lesion.
Schwartz, Roy
core  

Influence of subretinal drusenoid deposit on retinal sensitivity in age-related macular degeneration

Scientific Reports
This retrospective study aimed to assess the impact of subretinal drusenoid deposit (SDD), also known as reticular pseudodrusen, on retinal sensitivity (RS) in patients with intermediate age-related macular degeneration (iAMD) using microperimetry.
Soo Hyun Lim, Taffeta Ching Ning Yamaguchi, Rolf Herrmann, Eun Kyoung Lee, Kun Ho Bae, Un Chul Park, Kyu Hyoung Park, Chang Ki Yoon   +7 more
doaj   +1 more source