Results 51 to 60 of about 18,397 (221)

Spindle oscillations are generated in the dorsal thalamus and modulated by the thalamic reticular nucleus [PDF]

, 2008
Spindle waves occur during the early stage of slow wave sleep and are thought to arise in the thalamic reticular nucleus (TRN), causing inhibitory postsynaptic potential spindle-like oscillations in the dorsal thalamus that are propagated to the cortex ...
Chun-Hua Liu, Jufang He, Li-Xia Gao, Xian-Kai Meng, Yan-Qin Yu, Yi Ping Guo, Ying Xiong, Ying-Shing Chan   +7 more
core   +1 more source

Research progress on the role of inflammatory mediators in the pathogenesis of epilepsy

Ibrain, Volume 11, Issue 1, Page 44-58, Spring 2025.
In the central nervous system, activated immune cells lead to the overproduction of inflammatory mediators through the corresponding signal pathway. Under the stimulation of inflammatory factors, neuroinflammation ultimately occurs. Overexpression of inflammatory mediators and activated immunocytes plays an important role in the emergence and ...
Yue Yu, Fei‐Ji Sun
wiley   +1 more source

Thalamic circuit mechanisms link sensory processing in sleep and attention

Frontiers in Neural Circuits, 2016
The correlation between sleep integrity and attentional performance is normally interpreted as poor sleep causing impaired attention. Here, we provide an alternative explanation for this correlation: common thalamic circuits regulate sensory processing ...
Zhe eChen, Zhe eChen, Ralf D Wimmer, Ralf D Wimmer, Matthew eWilson, Michael M Halassa, Michael M Halassa, Michael M Halassa   +7 more
doaj   +1 more source

Involvement of the thalamic reticular nucleus in prepulse inhibition of acoustic startle

Translational Psychiatry, 2021
Thalamic reticular nucleus (TRN) is a group of inhibitory neurons surrounding the thalamus. Due to its important role in sensory information processing, TRN is considered as the target nucleus for the pathophysiological investigation of schizophrenia and
Qiang-long You, Zhou-cai Luo, Zheng-yi Luo, Ying Kong, Ze-lin Li, Jian-ming Yang, Xiao-wen Li, Tian-ming Gao   +7 more
doaj   +1 more source

The neural mechanisms of mindfulness-based pain relief: a functional magnetic resonance imaging-based review and primer. [PDF]

, 2019
The advent of neuroimaging methodologies, such as functional magnetic resonance imaging (fMRI), has significantly advanced our understanding of the neurophysiological processes supporting a wide spectrum of mind-body approaches to treat pain. A promising
Aguirre, Amanzio, Andrews-Hanna, Atlas, Atlas, Basbaum, Behzadi, Beitz, Benedetti, Bingel, Birn, Brown, Buchel, Buhle, Bushnell, Carlson, Casey, Cherkin, Coghill, Coghill, Creswell, Creswell, Creswell, Crick, Critchley, Daubenmier, Davey, Davis, Day, Deyo, Dunne, Dzau, Eippert, Eippert, Farb, Fox, Fox, Frid, Gard, Garland, Garland, Gatchel, Gaylord, Grant, Grant, Grevert, Grossman, Halassa, Han, Harris, Harrison, Holzel, Hughes, Jain, Kabat-Zinn, Kabat-Zinn, Kabat-Zinn, Kety, King, Kingston, Kong, Koyama, Kucyi, Lazar, Levine, Lindsay, Lord, Lui, Lutz, Lutz, Lutz, MacCoon, MacCoon, Maki-Marttunen, Mantyh, Mantyh, May, McAlonan, McCracken, Morone, Morone, Nelson, O'Doherty, Oshiro, Perthen, Peters, Petrovic, Petter, Poerio, Rahl, Restom, Rolls, Rosenkranz, Rostrup, Salomons, Saloner, Schooler, Schutze, Seminowicz, Seminowicz, Shapiro, Sharon, Sharon, Shires, Spreng, Sprenger, Starr, Stephenson, Steward, Svedin, Tang, Taylor, Taylor, Teper, Tracey, Turner, Vago, Valet, Villemure, Wager, Wager, Wager, Wang, Watkins, Way, Weese, Wells, Xu, Zeidan, Zeidan, Zeidan, Zeidan, Zeidan, Zeidan, Zeidan, Zeidan, Zeidan, Zeidan, Zeidan, Zikopoulos, Zikopoulos, Zikopoulos, Zubieta   +142 more
core   +1 more source

Quantitative Analysis of Locus Coeruleus Neurons and Thalamic Noradrenergic Axons in a Progressive 1‐Methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine Monkey Model of Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Parkinson's disease is mainly characterized by dopaminergic neurodegeneration in the substantia nigra pars compacta (SNc) and α‐synuclein accumulation. The locus coeruleus (LC) is also affected in Parkinson's disease and linked to some nonmotor symptoms, but the extent and timing of its degeneration remain unclear.
Megan Carrillo, Nagore Hernández‐Pinedo, Josefa Zaldivar‐Diez, Isabel Pérez‐Santos, José A. Obeso, Carmen Cavada, Javier Blesa   +6 more
wiley   +1 more source

Successive neuron loss in the thalamus and cortex in a mouse model of infantile neuronal ceroid lipofuscinosis

Neurobiology of Disease, 2007
Infantile neuronal ceroid lipofuscinosis (INCL) is caused by deficiency of the lysosomal enzyme, palmitoyl protein thioesterase 1 (PPT1). We have investigated the onset and progression of pathological changes in Ppt1 deficient mice (Ppt1−/−) and the ...
Catherine Kielar, Lucy Maddox, Ellen Bible, Charlie C. Pontikis, Shannon L. Macauley, Megan A. Griffey, Michael Wong, Mark S. Sands, Jonathan D. Cooper   +8 more
doaj   +1 more source

The Foxb1‐expressing neurons of the ventrolateral hypothalamic parvafox nucleus project to defensive circuits [PDF]

, 2016
The parvafox nucleus is an elongated structure that is lodged within the ventrolateral hypothalamus and lies along the optic tract. It comprises axially located parvalbumin (Parv)-positive neurons and a peripheral cuff of Foxb1-expressing ones. In the
Alvarez-Bolado, Gonzalo, Bilella, Alessandro, Celio, Marco R.   +2 more
core   +1 more source

Rapid generation of prion disease models using AAV‐delivered PrP variants in knockout mice

Brain Pathology, EarlyView.
We developed a rapid AAV‐based system to generate prion disease models in weeks rather than months. Following systemic AAV9P31 delivery of modified PrP to knockout mice, we achieved brain‐wide expression and successful propagation of both classical (RML) and atypical (GSS‐A117V) prion strains.
Maitena San‐Juan‐Ansoleaga, Eva Fernández‐Muñoz, Jorge M. Charco, Enric Vidal, Diego Herrero‐Martínez, Josu Galarza‐Ahumada, Cristina Sampedro‐Torres‐Quevedo, Samanta Giler, Mariví Geijo, Gloria González‐Aseguinolaza, Hasier Eraña, Joaquín Castilla   +11 more
wiley   +1 more source

Thalamic reticular nucleus induces fast and local modulation of arousal state

eLife, 2015
During low arousal states such as drowsiness and sleep, cortical neurons exhibit rhythmic slow wave activity associated with periods of neuronal silence.
Laura D Lewis, Jakob Voigts, Francisco J Flores, L Ian Schmitt, Matthew A Wilson, Michael M Halassa, Emery N Brown   +6 more
doaj   +1 more source