Results 91 to 100 of about 93,775 (268)

Evaluation of Thrombopoiesis in Thrombocytopenic Disorders by Simultaneous Measurement of Reticulated Platelets of Whole Blood and Serum Thrombopoietin Concentrations

, 1998
SummaryTo evaluate thrombopoiesis in thrombocytopenic disorders, we simultaneously determined reticulated platelet counts in whole blood by FACScan flow cytometry and serum thrombopoietin (TPO) concentrations by a sensitive sandwich ELISA.
Akiko Yoneyama, Tomoyuki Tahara, Kazuhiko Koike, Toshitugu Kariya, Sinji Sunaga, Tateru Ishida, Eriko Shoda, Masaaki Higashihara, Jun Shirai, Takashi Kato, Kouji Miyazaki, Ryoichi Horie, Iturou Ogata, Kazuhiko Nakahara, Yukako Koike, Katunori Aoki   +15 more
core   +1 more source

Increased Insulin Action, Glucose Metabolism and Muscle Function in Supervillin‐Knockout and Supervillin‐Mutant Mice

Cytoskeleton, EarlyView.
ABSTRACT We here describe mouse models with complementary homozygous Svil mutations. In skeletal muscle, Svil‐Mut mice express the Svil‐encoded N‐terminus fused to the βgal‐neo gene‐trap tag and lack the highly conserved archvillin C‐terminus; Svil‐KO mice lack expression of all known Svil‐encoded proteins; and Svil‐LoxP mice contain loxP sites for ...
Tara C. Smith, Lauren A. Tauer, Randall H. Friedline, Xiaodi Hu, Duy Tran, Yangyi E. Luo, Nacima Hadjout‐Rabi, Elisabeth R. Barton, Jason K. Kim, Elizabeth J. Luna   +9 more
wiley   +1 more source

It's reticulated: the liver at the heart of atherosclerosis

, 2018
Platelets play a critical role in both the initiation and progression of atherosclerosis, and even more so in the ensuing atherothrombotic complications.
Andrew J Murphy, Prabhakara R Nagareddy, Sunil K Noothi, Michelle C Flynn   +3 more
core   +1 more source

Clinical Significance of Acute Kidney Injury in Idiosyncratic Drug‐Induced Liver Injury: A Multicentric Propensity Scores Matched Study

Clinical Pharmacology &Therapeutics, EarlyView.
Clinical significance of acute kidney injury in idiosyncratic drug‐induced liver injury: a multicentric propensity scores matched study. Evidence about the role of acute kidney injury (AKI) in idiosyncratic drug‐induced liver injury (DILI) is still scarce.
José María Pinazo‐Bandera, Hao Niu, Juan Pedro Toro‐Ortiz, Inmaculada Medina‐Caliz, Judith Sanabria‐Cabrera, Aída Ortega‐Alonso, Mercedes Robles‐Díaz, Daniel Enrique Di Zeo‐Sanchez, Nelia Hernández, Fernando Bessone, Vinicius Nunes, Raymundo Paraná, M. Isabel Lucena, Raul J. Andrade, Ismael Alvarez‐Alvarez, Miren García‐Cortés   +15 more
wiley   +1 more source

Platelets from MI patients express PKCε protein.

, 2013
Panel A: A representative Western blot assay for the detection of total PKCε protein expression in platelets from PKCε mRNA-positive MI, sCAD and HD. β-Actin was assayed for protein loading.
Daniela Lina (303941), Francesca Notarangelo (303945), Luigi De Marco (303957), Maria Mattioli (303931), Prisco Mirandola (303930), Diego Ardissino (303954), Giuliana Gobbi (303961), Maria Rita Cozzi (303949), Marco Gesi (303952), Nicola Marziliano (303934), Marco Vitale (303959), Piera Angelica Merlini (303937), Cecilia Carubbi (303929), Daniela Galli (303932)   +13 more
core   +1 more source

Membrane lipid metabolism as a regulatory frontier in neural crest biology: Roles for sphingolipids, cholesterol, and lipid rafts

Developmental Dynamics, EarlyView.
Abstract Neural crest cells are multipotent, migratory stem‐like cells essential for vertebrate development that contribute broadly to many tissues including the craniofacial skeleton, peripheral nervous system, and pigment‐producing cells. Their development progresses through phases of induction, specification, delamination, migration, and ...
Allison E. Mancini, Mallorie P. Jenne, Michael L. Piacentino   +2 more
wiley   +1 more source

Reticulated platelets in acute coronary syndrome: A marker of platelet activity

Journal of the American College of Cardiology, 2004
To the Editor: Mean platelet volume (MPV) is elevated in patients with acute coronary syndrome (ACS) ([1][1]) and is used as an independent predictor of recurrent myocardial infarction and cardiac death ([2][2]). Reticulated platelets (RP) are newly formed platelets.
Lakkis, Nasser, Dokainish, Hisham, Abuzahra, Mohamad, Tsyboulev, Valeri, Jorgensen, Jefferey, Ponce De Leon, Audrie, Saleem, Abdus   +6 more
openaire   +1 more source

Transcriptome Analysis of Reticulated Platelets Reveals a Prothrombotic Profile

, 2019
Reticulated platelets (RPs) are larger, hyperreactive platelets that contain significantly more ribonucleic acid (RNA) compared with mature platelets (MPs).
Aslani M, Klug M, Moretti A, Peano C, Cibella J, Laugwitz KL, Weber C, Bongiovanni D, Felicetta A, Hristov M, Santamaria G, Bernlochner I, Santovito D, von Scheidt M   +13 more
core   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Commonalities of platelet dysfunction in heart failure with preserved ejection fraction and underlying comorbidities

ESC Heart Failure, Volume 12, Issue 2, Page 1013-1028, April 2025.
Abstract Heart failure with preserved ejection fraction (HFpEF) is characterized by a lack of a specific targeted treatment and a complex, partially unexplored pathophysiology. Common comorbidities associated with HFpEF are hypertension, atrial fibrillation, obesity and diabetes.
Giorgia D'Italia, Blanche Schroen, Judith M.E.M. Cosemans   +2 more
wiley   +1 more source