Results 71 to 80 of about 93,775 (268)

Characterization of autotransplant-related thrombocytopenia by evaluation of glycocalicin and reticulated platelets

, 1999
Thrombocytopoiesis of 21 multiple myeloma patients undergoing single or double transplant regimen was characterized by measuring the level of reticulated platelets and plasma glycocalicin.
LEMOLI, ROBERTO MASSIMO, Valdrè L, Valdre L., Castellani S., Vianelli N, Rizzi S., Catani L., Tura S., Luatti S., Catani L, Luatti S, Lemoli R. M., Vianelli N., Rizzi S, Castellani S   +14 more
core   +1 more source

A Dual‐Delivery System Designed to Overcome EV‐Mediated Ferroptosis Resistance for Efficient Solid Tumor Therapy

Advanced Science, EarlyView.
(A) Establishment and characterization of the osteosarcoma‐targeted dual‐delivery nanoplatform mBAP1/siENO1@LNP‐OTP for simultaneous regulation of BAP1 and ENO1 in tumor cells. (B) After intravenous administration, mBAP1/siENO1@LNP‐OTP preferentially accumulates at tumor sites through OTP‐mediated targeting.
Yechao Shen, Zhenguo Cao, Zenan Wang, Liang Chen, Jiahao Zhang, Linjie Zeng, Boren Tan, Hengyuan Li, Jiashan Lai, Jiangchu Lei, Fanglu Chen, Peng Lin, Zhenxuan Shao, Zhan Wang   +13 more
wiley   +1 more source

Polyphosphate Copper Nanospheres Drive Mitochondrial Metabolic Reprogramming via Calcium Phase Separation for Self‐Sensitizing Cuproptosis

Advanced Science, EarlyView.
This study developed polyphosphate (polyP)‐based nanostructures that enable calcium‐mediated metabolic reprogramming via liquid–liquid phase separation (LLPS). Released polyP undergoes LLPS with Ca2+, suppressing glycolytic flux and enhancing mitochondrial metabolism effectively.
Jing Wang, Xinyang Zhao, Zifeng Huang, Jingyi Zhang, Yucheng Tao, Yong Huang, Zijian Guo, Lei Dong, Xiuxiu Wang, Jing Zhao, Wei Wei   +10 more
wiley   +1 more source

Impact of aging on immature platelet count and its relationship with coronary artery disease

Platelets, 2020
Despite the fact that elderly patients represent a prevalent and challenging population in the current practice, few data exist on the impact of platelet parameters on cardiovascular risk in these patients.
Monica Verdoia, Matteo Nardin, Federica Negro, Francesco Tonon, Rocco Gioscia, Roberta Rolla, Giuseppe De Luca   +6 more
doaj   +1 more source

Compartmentalized megakaryocyte death generates functional platelets committed to caspase-independent death [PDF]

, 2003
Caspase-directed apoptosis usually fragments cells, releasing nonfunctional, prothrombogenic, membrane-bound apoptotic bodies marked for rapid engulfment by macrophages.
Jones, David B., Simon B. Brown, Brown, Simon B, Murray C.H. Clarke, David B. Jones, Savill, John, Brendon S. Noble, Clarke, Murray C H, Noble, Brendon S, John Savill, Brown, Simon B., Clarke, Murray C.H., Noble, Brendon S.   +12 more
core   +1 more source

Large Oncosomes Induce Pro‐Metastatic Stromal‐Myeloid Reprogramming

Advanced Science, EarlyView.
Large oncosomes systemically reprogram bone marrow mesenchymal stem cells through innate nucleic acid sensing, driving inflammatory and immunosuppressive remodeling that supports a metastasis‐permissive bone marrow environment, revealing a novel tumor‐host communication axis in cancer. ABSTRACT Bone metastasis can be facilitated by systemic remodeling,
Taylon Felipe Silva, Virginia Marcia Concato‐Lopes, Fatima Bedier, Lauren Newman, Diana Kitka, Jamelle Brown, Blandine Victor, Minhyung Kim, Tatyana Vagner, Catherine Grasso, Dmitriy Sheyn, Sungyong You, Michael R. Freeman, Fayyaz S. Sutterwala, Helen S. Goodridge, Caroline Jefferies, Paola de Candia, Jlenia Guarnerio, Dolores Di Vizio   +18 more
wiley   +1 more source

Disparate effects of adhesion and degranulation of platelets on myocardial and coronary function in postischaemic hearts [PDF]

, 1998
Beside the major effect of acute thrombus formation, little is known about the interaction of platelets with the coronary endothelium in an ischaemia–reperfusion situation.
Welsch, Ulrich, Heindl, Bernhard, Zahler, Stefan, Becker, Bernhard F.   +3 more
core   +1 more source

Additional file 4 of Functional enrichment of alternative splicing events with NEASE reveals insights into tissue identity and diseases

, 2021
Additional file 4: Tables S12-S16. Differential splicing analysis between reticulated platelets and mature platelets. Table S12. List of spliced domains. Table S13. List of affected edges. Table S14. Gene-level enrichment. Table S15.
Tim Kacprowski (793348), Amit Fenn (11788175), Chit Tong Lio (9432902), Zsolt Illes (441094), Markus List (3621461), Jan Baumbach (14867), Dario Bongiovanni (8307699), Zakaria Louadi (11788169), Olga Tsoy (11788178), Maria L. Elkjaer (5638730), Melissa Klug (11788172)   +10 more
core   +1 more source

Targeting Mitochondrial Redox Signaling Promotes Neuroregeneration and Functional Recovery in a Multiple Sclerosis Model

Advanced Science, EarlyView.
Modulation of mitochondrial redox signaling by furapyrrodole activates CYB5R3 and suppresses Notch signaling, unlocking the regenerative potential of endogenous neural progenitor cells. This approach promotes neurogenesis, oligodendrogenesis, and remyelination, thereby improving neuronal function in a mouse model of multiple sclerosis and identifying ...
Yuki Narushima, Joshua Saylor, Shun Saito, Jinyan Zhou, Haruka Kawano, Shehata Anwar, Haruki Oba, Rachel Huezo, Miyu Okano, Haruki Matsuda, Makoto Kawatani, Kaori Honda, Hiroyuki Osada, Yuta Kikuchi, Masahito Ohue, Masami Ishibashi, Takayoshi Arai, Makoto Inoue, Midori A. Arai   +18 more
wiley   +1 more source

Idiopathic thrombocytopenic purpura

Contemporary Clinical Dentistry, 2014
Idiopathic thrombocytopenic purpura (ITP) is defined as a hematologic disorder, characterized by isolated thrombocytopenia without a clinically apparent cause.
L Kayal, S Jayachandran, Khushboo Singh
doaj   +1 more source