Results 91 to 100 of about 42,523 (238)
ABSTRACT Acute chest syndrome (ACS) is one of the most common severe complications of sickle cell disease (SCD). In recent years, a major role of inflammation and innate immunity has been evidenced, but ACS pathophysiology remains incompletely understood, and therapeutic options are limited.
Slimane Allali +14 more
wiley +1 more source
Number of reticulocyte can indicate efficiency of bone marrow on erythropoiesis. It also aids in diagnosis and follow up anemic patients. In addition, it can be used for determination of new red blood cell production after bone marrow transplantation. In
Prapai Hemhorm +6 more
doaj
ABSTRACT Sickle cell disease (SCD) is a chronic inflammatory state, characterized by increased plasma values of inflammatory and angiogenic proteins. Although red blood cell (RBC) transfusion is known to have immunomodulatory effects in other conditions, its potential effects on the inflammatory state in SCD remain largely unknown.
Lydian A. de Ligt +9 more
wiley +1 more source
Genetics and Genomics in Sickle Cell Disease in Africa
ABSTRACT Advanced genomic technologies are revolutionizing our ability to understand complex diseases. Large‐scale population studies are needed to realize the potential of using individual genetic information to personalize treatments for better patient outcomes for chronic non‐communicable diseases, such as sickle cell disease (SCD).
Siana Nkya +2 more
wiley +1 more source
Carbon monoxide to ‘simulate altitude’: The ethical grenade
Experimental Physiology, EarlyView.
Raphael Faiss, Franck Brocherie
wiley +1 more source
Effects of Immunoadsorption on Markers of Iron Metabolism: A Case Series
ABSTRACT Immunoadsorption selectively eliminates circulating antibodies in antibody‐mediated diseases. Iron deficiency is the most common cause of anemia; however, the potential role of immunoadsorption in contributing to iron depletion remains insufficiently established.
Noemi E. Ginthör +10 more
wiley +1 more source
ABSTRACT A 28‐year‐old male with paroxysmal nocturnal haemoglobinuria (PNH) presented with headache, nasal bridge discomfort and haemoglobinuria. He developed a macular‐papular rash which rapidly progressed into purpura, necrosis and peri‐orbital oedema. Investigations demonstrated severe haemolytic anaemia and acute parvovirus B19 infection.
Louise J. Potter +9 more
wiley +1 more source
Successful Treatment of Aplastic Anemia With Eltrombopag During Pregnancy: A Short Report
ABSTRACT Introduction Aplastic anemia (AA) is a rare bone marrow failure syndrome with pancytopenia, mainly due to immune‐mediated stem cell destruction. First‐line therapy for acquired severe AA ≥ 50 years/non‐severe AA (NSAA) requiring treatment is immunosuppressive therapy with horse anti‐thymocyte globulin, cyclosporine A (CSA), and eltrombopag ...
Sandra M. Frey +3 more
wiley +1 more source
Functions of J‐domain proteins in mitochondrial protein biogenesis
Abstract Mitochondrial biogenesis and functions depend on the import and assembly of more than 1000 proteins that are made as precursors on cytosolic ribosomes. The majority of these precursor proteins are transported from the ribosome to the translocase of the outer membrane (TOM complex), which constitutes the main entry site for mitochondrial ...
Vitasta Tiku +3 more
wiley +1 more source
Innovative Hematology Analysis Using Menstrual Blood
Endah Wulandari,1 Rr Ayu Fitri Hapsari2 1Department of Biochemistry, Islamic State University Syarif Hidayatullah Jakarta of Medicine Faculty, South Tangerang, Banten, Indonesia; 2Department of Histology, Islamic State University Syarif Hidayatullah ...
Wulandari E, Hapsari RAF
doaj

