Results 31 to 40 of about 376,903 (143)

Prognostic risk factors of colorectal cancer patients with stage pT_4bN₀M₀

Zhongguo linchuang yanjiu
Objective To analyze the prognostic characteristics of different invasion sites and the risk factors affecting overall prognosis, in patients with pT4b stage colorectal cancer who underwent radical resection and showed no lymph node metastasis （N0） by ...
DONG Jiuxing, ZHAO Jia, WU Zhenming, LIU Jun, WANG Baoxin, SU Yu, QI Xiuheng   +6 more
doaj   +1 more source

Membrane-associated RING ubiquitin ligase RNF-121 and advancement of cancer [PDF]

Cellular, Molecular and Biomedical Reports
Exploration of E3 ubiquitin ligases as potential therapeutic targets has been ongoing for two to three decades. Various chemicals and drugs have been developed to either upregulate or inhibit the activity of E3 ligases, aiming to mitigate several ...
Somesh Roy
doaj   +1 more source

Regulation and function of endoplasmic reticulum autophagy in neurodegenerative diseases

Neural Regeneration Research
The endoplasmic reticulum, a key cellular organelle, regulates a wide variety of cellular activities. Endoplasmic reticulum autophagy, one of the quality control systems of the endoplasmic reticulum, plays a pivotal role in maintaining endoplasmic ...
Xiu-Yun Zhao, De-En Xu, Ming-Lei Wu, Ji-Chuan Liu, Zi-Ling Shi, Quan-Hong Ma   +5 more
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Hypoxia-Induced Sarcoplasmic Reticulum Ca2+ Leak Is Reversed by Ryanodine Receptor Stabilizer JTV-519 in HL-1 Cardiomyocytes

Anatolian Journal of Cardiology, 2022
Background: To assess whether hypoxia, as can be found in obstructive sleep apnea syndrome, is causally associated with the development of heart failure through a direct effect on calcium leakage from the sarcoplasmic reticulum.
Minh Duc Trinh, Ivana Fišerová, Lukáš Vacek, Marek Heide, Jan Pala, Petr Tousek, Jan Polak   +6 more
doaj   +1 more source

Stress-induced neuroprotective effects of epiregulin and amphiregulin. [PDF]

PLoS ONE, 2015
Members of the epidermal growth factor family play important roles in the regulation of cell growth, proliferation, and survival. However, the specific roles of each epidermal growth factor family member with respect to brain injury are not well ...
Libin Zhan, Luping Zheng, Toru Hosoi, Yasunobu Okuma, Yasuyuki Nomura   +4 more
doaj   +1 more source

Transport of cholesterol from the endoplasmic reticulum to the plasma membrane is constitutive in CaCo-2 cells and differs from the transport of plasma membrane cholesterol to the endoplasmic reticulum

Journal of Lipid Research, 1998
The transport of newly synthesized cholesterol from its site of synthesis, the endoplasmic reticulum, to the plasma membrane was studied in CaCo-2 cells. The appearance of newly synthesized cholesterol on the cell surface was rapid. By 30 min, 50% of the
F. Jeffrey Field, Ella Born, Shubha Murthy, Satya N. Mathur   +3 more
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Effect of hypoxia, glutamine and glucose deprivation on the expression of mRNA of the retinoblastoma binding proteins in glioma cells

Біологічні студії, 2011
Hypoxia and ischemia, as well as endoplasmic reticulum stress, are principal factors which are necessary for tumor neovascularization and growth. We have studied the effect of blocking the endoplasmic reticulum – nuclei-1, the main signaling enzyme of ...
D. O. Minchenko, L. L. Karbovskyi, S. V. Danylovsky, M. Moenner, O. H. Minchenko   +4 more
doaj   +1 more source

Ferroptosis and endoplasmic reticulum stress in ischemic stroke

Neural Regeneration Research
Ferroptosis is a form of non-apoptotic programmed cell death, and its mechanisms mainly involve the accumulation of lipid peroxides, imbalance in the amino acid antioxidant system, and disordered iron metabolism.
Yina Li, Mingyang Li, Shi Feng, Qingxue Xu, Xu Zhang, Xiaoxing Xiong, Lijuan Gu   +6 more
doaj   +1 more source

Endoplasmic reticulum stress-induced apoptosis in the penumbra aggravates secondary damage in rats with traumatic brain injury

Neural Regeneration Research, 2016
Neuronal apoptosis is mediated by intrinsic and extrinsic signaling pathways such as the membrane-mediated, mitochondrial, and endoplasmic reticulum stress pathways.
Guo-zhu Sun, Fen-fei Gao, Zong-mao Zhao, Hai Sun, Wei Xu, Li-wei Wu, Yong-chang He   +6 more
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Calcium bridges built by mitochondria-associated endoplasmic reticulum membranes: potential targets for neural repair in neurological diseases

Neural Regeneration Research
The exchange of information and materials between organelles plays a crucial role in regulating cellular physiological functions and metabolic levels. Mitochondria-associated endoplasmic reticulum membranes serve as physical contact channels between the ...
Yichen Peng, Li Zhou, Yaju Jin, Danli Wu, Na Chen, Chengcai Zhang, Hongpeng Liu, Chunlan Li, Rong Ning, Xichen Yang, Qiuyue Mao, Jiaxin Liu, Pengyue Zhang   +12 more
doaj   +1 more source