Results 41 to 50 of about 395,730 (157)
Retinal capillary nonperfusion in preclinical diabetic retinopathy [PDF]
, 2023 The aim of the study was to identify retinal microvascular changes using optical coherence tomography angiography (OCTA) in type 2 diabetes (T2D) patients with preclinical retinopathy identified by ultra-widefield fundus photography (UWF-FP).
Foote, Katharina +9 more
core +1 more source
Retinal glial cells in von hippel–lindau disease: A novel approach in the pathophysiology of retinal hemangioblastoma [PDF]
, 2021 Background: Von Hippel–Lindau (VHL) disease is a neoplastic syndrome caused by a mutation of the VHL tumor suppressor gene. Retinal hemangioblastoma (RH) is a vascularized tumor and represents the most common ocular manifestation of this disease.
Torresin T. +15 more
core +2 more sources
Whole‐exome sequencing and immunohistochemistry findings in von Hippel–Lindau disease
Molecular Genetics &Genomic Medicine, Volume 7, Issue 9, September 2019., 2019 Whole‐exome sequencing of a VHL pedigree with peripheral blood and tumor tissue was performed. No somatic point mutations, except for the VHL gene, that cause VHL‐related tumor occurrence were recognized. Immunohistochemistry of the tumors showed that phospho‐S6 ribosomal protein in the mTOR pathway could be a potential target in VHL‐related cerebellum
Xiaopeng Guo +7 more
wiley +1 more source
Sporadic Retroperitoneal Hemangioblastoma: Report of a Case and Review of the Literature
Case Reports in Pathology, Volume 2017, Issue 1, 2017., 2017 We report a case of sporadic isolated hemangioblastoma arising from the retroperitoneum and provide a review of the scarce literature regarding this very rare tumor. Furthermore, we thoroughly describe the pathologic features and the broad differential diagnosis that should always be included in the study of any retroperitoneal soft tissue mass to ...
F. G. Jalikis +4 more
wiley +1 more source
An Update on the Ophthalmologic Features in the Phakomatoses
Journal of Ophthalmology, Volume 2016, Issue 1, 2016., 2016 Neurofibromatosis type 1, tuberous sclerosis complex, and Von Hippel‐Lindau disease, historically classified as the phakomatoses, are hereditary multisystem disorders characterized by the presence of hamartoma, which carry the risk of malignant transformation. The alteration of tumor suppressor genes seems to be at the basis of their pathophysiogenetic
Solmaz Abdolrahimzadeh +4 more
wiley +1 more source
BioMed Research International, Volume 2015, Issue 1, 2015., 2015 The cardiovascular system ensures the delivery of oxygen and nutrients to all cells, tissues, and organs. Under extended exposure to reduced oxygen levels, cells are able to survive through the transcriptional activation of a series of genes that participate in angiogenesis, glucose metabolism, and cell proliferation.
Agnieszka Zimna +2 more
wiley +1 more source
Von Hippel-Lindau Disease and the Eye
Journal of Ophthalmic & Vision Research, 2020 Retinal hemangioblastoma (also referred to as retinal capillary hemangioma) is a benign lesion originating from the endothelial and glial components of the neurosensory retina and optic nerve head.
Saeed Karimi +3 more
doaj +1 more source
Photodynamic Therapy for Juxtapapillary Retinal Capillary Hemangioma
Case Reports in Ophthalmological Medicine, Volume 2014, Issue 1, 2014., 2014 Various treatment modalities have been described for retinal capillary hemangioma. Our purpose is to present a case of juxtapapillary retinal capillary hemangioma treated with photodynamic therapy. A 69‐year‐old woman with no previous ocular history presented with blurred vision and photopsias in the right eye three months ago.
Panagiotis G. Mitropoulos +7 more
wiley +1 more source
Development of Anti‐VEGF Therapies for Intraocular Use: A Guide for Clinicians
Journal of Ophthalmology, Volume 2012, Issue 1, 2012., 2012 Angiogenesis is the process by which new blood vessels form from existing vessel networks. In the past three decades, significant progress has been made in our understanding of angiogenesis; progress driven in large part by the increasing realization that blood vessel growth can promote or facilitate disease.
Pearse A. Keane +2 more
wiley +1 more source
Case Reports in Ophthalmology, 2020 This case report aims to describe the diagnosis, treatment, and evolution of bilateral, asymmetrical retinal capillary hemangioblastomas treated with argon laser and intravitreal anti-vascular endothelial growth factor and also reports the results of an ...
Carlos Andrés Valdés-Lara +4 more
doaj +1 more source