Results 1 to 10 of about 103,348 (164)
Microglial phagocytosis of bipolar cells triggers inner retinal degeneration in Rs1-KO mice [PDF]
Cell Communication and SignalingBackground X-linked juvenile retinoschisis (XLRS) is a hereditary retinal disorder caused by mutations in the RS1 gene that leads to the formation of cavities in the inner nuclear layer (INL) and progressive vision loss, characterized by a ...
Jin Young Yang +10 more
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Oxysterols and retinal degeneration [PDF]
British Journal of Pharmacology, 2021 Retinal degeneration, characterised by the progressive death of retinal neurons, is the most common cause of visual impairment. Oxysterols are the cholesterol derivatives produced via enzymatic and/or free radical oxidation that regulate cholesterol homeostasis in the retina.
Zhang, Xun +6 more
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Cell Death Discovery, 2022 Retinal organoids derived from human-induced pluripotent stem cells (hiPSC) are powerful tools for studying retinal development as they model spatial and temporal differentiation of retinal cell types.
Si Hyung Lee +12 more
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Whole-exome sequencing in 168 Korean patients with inherited retinal degeneration
BMC Medical Genomics, 2021 Background To date, no genetic analysis of inherited retinal disease (IRD) using whole-exome sequencing (WES) has been conducted in a large-scale Korean cohort.
Dae Joong Ma +8 more
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Lentiviral Vectors for Ocular Gene Therapy
Pharmaceutics, 2022 This review offers the basics of lentiviral vector technologies, their advantages and pitfalls, and an overview of their use in the field of ophthalmology.
Yvan Arsenijevic +3 more
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Complement C3a receptor inactivation attenuates retinal degeneration induced by oxidative damage
Frontiers in Neuroscience, 2022 Retinal degeneration causes vision loss and threatens the health of elderly individuals worldwide. Evidence indicates that the activation of the complement system is associated with retinal degeneration.
Shaojun Wang +4 more
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Polarized RPE Secretome Preserves Photoreceptors in Retinal Dystrophic RCS Rats
Cells, 2023 Retinal degenerative diseases, including age-related macular degeneration (AMD) and retinitis pigmentosa, lack effective therapies. Conventional monotherapeutic approaches fail to target the multiple affected pathways in retinal degeneration.
Kabir Ahluwalia +10 more
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Development and degeneration of cone bipolar cells are independent of cone photoreceptors in a mouse model of retinitis pigmentosa. [PDF]
PLoS ONE, 2012 Retinal photoreceptors die during retinal synaptogenesis in a portion of retinal degeneration. Whether cone bipolar cells establish regular retinal mosaics and mature morphologies, and resist degeneration are not completely understood.
Miao Chen, Ke Wang, Bin Lin
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Peripapillary Intravitreal Injection Improves AAV-Mediated Retinal Transduction
Molecular Therapy: Methods & Clinical Development, 2020 The intravitreal (IVT) injection method is a choice when targeting the inner retina for gene therapy. However, the transduction efficiency of adeno-associated virus (AAV) vectors administered by the IVT route is usually low and may be affected by several
Sanjar Batirovich Madrakhimov +5 more
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Journal of Neuroinflammation, 2023 Background Chronic inflammation significantly contributes to photoreceptor death in blinding retinal diseases such as age-related macular degeneration (AMD) and retinitis pigmentosa (RP). Bromodomain and extraterminal domain (BET) proteins are epigenetic
Xingfei Zhu +13 more
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