Results 1 to 10 of about 80,958 (114)
Oxysterols and retinal degeneration [PDF]
British Journal of Pharmacology, 2021 Retinal degeneration, characterised by the progressive death of retinal neurons, is the most common cause of visual impairment. Oxysterols are the cholesterol derivatives produced via enzymatic and/or free radical oxidation that regulate cholesterol homeostasis in the retina.
James Reilly +8 more
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Microglia in Retinal Degeneration [PDF]
Frontiers in Immunology, 2019 The retina is a complex tissue with multiple cell layers that are highly ordered. Its sophisticated structure makes it especially sensitive to external or internal perturbations that exceed the homeostatic range. This necessitates the continuous surveillance of the retina for the detection of noxious stimuli.
Khalid Rashid +3 more
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Necroptosis and Neuroinflammation in Retinal Degeneration
Frontiers in Neuroscience, 2022 Necroptosis mediates the chronic inflammatory phenotype in neurodegeneration. Receptor-interacting protein kinase (RIPK) plays a pivotal role in the induction of necroptosis in various cell types, including microglia, and it is implicated in diverse neurodegenerative diseases in the central nervous system and the retina.
Yan Tao +3 more
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Neural Reprogramming in Retinal Degeneration [PDF]
Investigative Opthalmology & Visual Science, 2007 Early visual defects in degenerative diseases such as retinitis pigmentosa (RP) may arise from phased remodeling of the neural retina. The authors sought to explore the functional expression of ionotropic (iGluR) and group 3, type 6 metabotropic (mGluR6) glutamate receptors in late-stage photoreceptor degeneration.Excitation mapping with organic ...
Marc, Robert E +7 more
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Alternative splicing and retinal degeneration [PDF]
Clinical Genetics, 2013 Alternative splicing is highly regulated in tissue-specific and development-specific patterns, and it has been estimated that 15% of disease-causing point mutations affect pre-mRNA splicing. In this review, we consider the cis-acting splice site and trans-acting splicing factor mutations that affect pre-mRNA splicing and contribute to retinal ...
Melissa M. Liu, Donald J. Zack
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Retinal Degeneration in the Fly [PDF]
, 2011 Many genes are functionally equivalent between flies and humans. In addition, the same, or similar, mutations cause disease in both species. In fact, nearly three-fourths of all human disease genes have related sequences in Drosophila. The fly has a relatively small genome, made up of about 13,600 genes in four pairs of chromosomes.
openaire +3 more sources
Complement Activation in Retinal Degeneration [PDF]
, 2011 Our aim is to investigate a common role of the complement system in the pathogenesis of retinal disease, by assessing the expression profile of complement component 3 (C3) in three mechanistically distinct models of retinal degeneration: light-damage, hyperoxia and the degenerative P23H-3 rodent strain.
Rutar, Matthew +3 more
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Retinal degeneration mutants in the mouse
Vision Research, 2002 The Jackson Laboratory, having the world's largest collection of mouse mutant stocks and genetically diverse inbred strains, is an ideal place to look for genetically determined eye variations and disorders. Through ophthalmoscopy, electroretinography and histology, we have discovered disorders affecting all aspects of the eye including the lid, cornea,
Chang, B +5 more
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Peroxisomal Disorders and Retinal Degeneration [PDF]
, 2019 Peroxisomal disorders are a group of inherited metabolic diseases, which can be incompatible with life in the postnatal period or allow survival into adulthood. Retinopathy is a recurrent feature in both the severely and mildly affected patients, which can be accompanied with other ophthalmological pathologies.
Das, Yannick, Baes, Myriam
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Gene Therapy for Retinal Degeneration [PDF]
Ophthalmic Research, 1997 Inherited retinal degenerations are a group of diseases leading to blindness through progressive loss of vision in many patients. Although with the cloning of more and more disease genes the knowledge on the molecular genetics of these conditions and on the apoptotic pathway as the common disease mechanism is steadily increasing, there is still no cure
David M. Hunt +3 more
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