Results 191 to 200 of about 110,472 (262)

Glycosylation-driven necroptosis in retinal degeneration: dual rescue by AAV8 gene therapy and RIPK1 inhibition. [PDF]

Cell Death Discov
Chien JY, Woon PY, Tsai HY, Peng ML, Lee SH, Chau SF, Chen YC, Cheang WM, Tsai CY, Huang SP.   +9 more
europepmc   +1 more source

Regional growth kinetics of geographic atrophy in age‐related macular degeneration with and without fovea‐sparing

Acta Ophthalmologica, EarlyView.
Abstract Purpose Fovea‐sparing geographic atrophy (GA) patients retain near‐normal central vision. To better understand GA progression in relation to the fovea, we performed a semi‐automated image analysis of regional atrophy growth in a long‐term GA natural‐history cohort. Methods Prospective‐observational, single‐centre‐study (02/2013–07/2025) at the
Daniel R. Muth, Abinaya P. Venkataraman, Alberto Dominguez‐Vicent, Goran Petrovski, Pete A. Williams, Laurence Quérat, Filippo Locri, Sandrine A. Zweifel, Anders Kvanta   +8 more
wiley   +1 more source

RPE Abnormality Is a Potential Primary Cause for Retinal Degeneration in Mucopolysaccharidosis Type VI Patients and a Rat Model. [PDF]

Invest Ophthalmol Vis Sci
Sho J, Nakamura N, Onishi A, Watanabe M, Sakai D, Hirami Y, Mandai M, Kurimoto Y, Takahashi M, Maeda A.   +9 more
europepmc   +1 more source

CD93—An emerging vascular target in cancer therapy

British Journal of Pharmacology, EarlyView.
Abstract CD93 is a single‐pass transmembrane glycoprotein that belongs to the C‐type lectin domain group XIV family of proteins. Although it is known to be expressed in other cell types, namely, in some subsets of immune cells, CD93 is primarily expressed on endothelial cells, where it acts as a crucial regulator of angiogenesis.
Beatriz de Alves Pereira, Stefano Barbera, Roberta Lugano, Anna Dimberg   +3 more
wiley   +1 more source

Retinal Degeneration in Alzheimer's Disease 5xFAD Mice Fed DHA-Enriched Diets. [PDF]

Cells
Pinho MS, Ahfaz H, Carvalho S, Correia J, Spínola M, Pestana JM, Bandarra NM, Lopes PA.   +7 more
europepmc   +1 more source

Structural and biochemical basis for retinol‐binding protein 4 antagonism by tinlarebant

British Journal of Pharmacology, EarlyView.
Background and Purpose Retinol‐binding protein 4 (RBP4) is a member of the lipocalin superfamily that is connected to disease states such as insulin resistance, fatty liver disease and ocular disorders including Stargardt disease. Several retinoid and non‐retinoid antagonists of this protein have been developed for potential clinical use, but none have
Marco Bassetto, Philip D. Kiser
wiley   +1 more source

The Role of Autophagy-Lysosomal Pathways in Photoreceptor Death in the rd10 Mouse Model of Inherited Retinal Degeneration. [PDF]

Cells
Vessey KA, Hosseini Naveh N, Ehrlich O, Glover A, Lee J, Greferath U, Jobling AI, Fletcher EL.   +7 more
europepmc   +1 more source

Australian and New Zealand Glaucoma Society (ANZGS) Consensus on Interventional Glaucoma

Clinical &Experimental Ophthalmology, EarlyView.
ABSTRACT Background Traditional reactive ‘wait and see’ approaches in glaucoma management often result in unacceptable rates of permanent vision loss. This consensus defines a proactive ‘interventional glaucoma’ framework tailored for the Australian and New Zealand healthcare context. Methods A modified Delphi consensus process was utilised, consisting
Graham A. Lee, Lance Liu, Ridia Lim, Rajiv Shah, Robert J. Casson, Keith R. Martin, Helen Danesh‐Meyer, Ashish Agar, Jennifer C. Fan Gaskin, Judy Y. Ku, Geoffrey Chan, Anna Galanopoulos, Shamira Perera   +12 more
wiley   +1 more source

Nasal Retinal Degeneration Is a Feature of a Subset of <i>CRX</i>-Associated Retinopathies. [PDF]

Genes (Basel)
Massengill MT, Juvier Riesgo T, Davis JL, Mendoza-Santiesteban CE, Goldhagen BE, Lam BL, Gregori NZ.   +6 more
europepmc   +1 more source

CRB1‐Associated Inherited Retinal Dystrophies: Prospective Natural History Study With 4 Years of Follow‐Up

Clinical &Experimental Ophthalmology, EarlyView.
ABSTRACT Background The lack of validated and sensitive clinical endpoints remains a major challenge in the design of gene therapy trials for inherited retinal dystrophies (IRDs). This prospective longitudinal cohort study describes the natural disease progression of IRDs caused by pathogenic mutations in the Crumbs homologue 1 (CRB1) gene, and ...
Jessica S. Karuntu, Xuan‐Thanh‐An Nguyen, Mays Talib, Mary J. van Schooneveld, Jan Wijnholds, Maria M. van Genderen, Jos Twisk, Nicoline E. Schalij‐Delfos, Caroline C. W. Klaver, Ralph J. Florijn, Jacoline B. ten Brink, Magda A. Smoor, L. Ingeborgh van den Born, Carel B. Hoyng, Alberta A. H. J. Thiadens, Camiel J. F. Boon   +15 more
wiley   +1 more source