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Rabbit model of oxidative stress-induced retinal degeneration. [PDF]

Free Radic Biol Med
Kanan Y, Zhang J, Bernardo-Colón A, Debnath S, Khan M, Becerra SP, Campochiaro PA.   +6 more
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Modeling of retinal degeneration

Bulletin of Experimental Biology and Medicine, 2021
We developed a model of retinal degeneration in rabbits based on exposure to light with a wavelength of 405 nm. This model allows reproducing structural and functional disorders in the central parts of the retina, including primarily degeneration of the outer layers of the retina (retinal pigment epithelium and layer of photoreceptor cells), and is ...
A A, Suetov, E V, Boiko, S I, Alekperov, M A, Odinokaya, A A, Kostina   +4 more
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Retinal Degeneration in Kittens

Journal of the American Veterinary Medical Association, 1973
SUMMARY Diffuse outer segment retinal degeneration was found in 2 Persian kittens in each of 2 successive litters by 15 weeks of age. Clinical signs were mydriasis, tapetal hyperreflectivity, retinal vascular attenuation, and abnormalities in visual behavior. The disease seemed to be inherited as a simple autosomal recessive trait.
L F, Rubin, D E, Lipton
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RETINAL DEGENERATION IN GREYHOUNDS

Australian Veterinary Journal, 1980
Retinal degeneration in 10 Greyhounds with clinical and ophthalmoscopic features is described, including results of electroretinography and fluorescein angiography for one affected dog. Clinical and histologic features differed from other kinds of retinal degeneration in dogs.
D H, Slatter, J R, Blogg, I J, Constable
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Retinal remodeling during retinal degeneration

Experimental Eye Research, 2005
Retinal degenerations, regardless of the initiating event or gene defect, often result in a loss of photoreceptors. This formal deafferentation of the neural retina eliminates the intrinsic glutamatergic drive of the sensory retina and, perhaps more importantly, removes coordinated Ca++-coupled signaling to the neural retina.
Bryan W, Jones, Robert E, Marc
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Nutrition and Retinal Degenerations

International Ophthalmology Clinics, 2000
Considerable progress has been made in the understanding and management of degenerative diseases of the retina involving photoreceptors. Nutritional approaches to treatment have proved successful in the case of the common forms of retinitis pigmentosa (supplementation with vitamin A), Bassen-Kornzweig disease (supplementation with vitamins A, E, and K),
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Lipid peroxidation and retinal degeneration

Current Eye Research, 1984
Retinal degenerations were produced in albino rats by exposure to constant illumination or in frogs and albino rats by intravitreal injections of ferrous sulfate. Both treatments resulted in the loss of long-chain polyunsaturated fatty acids and the accumulation of lipid hydroperoxides in isolated rod outer segments.
R E, Anderson, L M, Rapp, R D, Wiegand
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Peripapillary Pigmentary Retinal Degeneration

American Journal of Ophthalmology, 1978
We studied four patients with peripapillary pigmentary retinal degeneration, an asymptomatic disorder that was probably benign and nonprogressive. The ophthalmoscopic appearance showed a segmental, grayish metallic sheen in association with bone spicule pigmentation, which radiated from the disk along the temporal vessel arcades and joined temporal to ...
K G, Noble, R E, Carr
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