Results 41 to 50 of about 640,739 (357)

Susceptibility to neurodegeneration in a glaucoma is modified by bax gene dosage. [PDF]

PLoS Genetics, 2005
In glaucoma, harmful intraocular pressure often contributes to retinal ganglion cell death. It is not clear, however, if intraocular pressure directly insults the retinal ganglion cell axon, the soma, or both.
Richard T Libby, Yan Li, Olga V Savinova, Joseph Barter, Richard S Smith, Robert W Nickells, Simon W M John   +6 more
doaj   +2 more sources

Retinal changes in an ATP-induced model of retinal degeneration

Frontiers in Neuroanatomy, 2016
In rodents and felines, intravitreal administration of adenosine triphosphate (ATP) has been shown to induce photoreceptor death providing a tractable model of retinal degeneration in these species.
Felix Peter Aplin, Kirstan Anne Vessey, Chi D Luu, Robyn H Guymer, Robert K Shepherd, Erica Lucy Fletcher   +5 more
doaj   +1 more source

Nrl knockdown by AAV-delivered CRISPR/Cas9 prevents retinal degeneration in mice

Nature Communications, 2017
In retinitis pigmentosa, loss of cone photoreceptors leads to blindness, and preservation of cone function is a major therapeutic goal. However, cone loss is thought to occur as a secondary event resulting from degeneration of rod photoreceptors. Here we
Wenhan Yu, Suddhasil Mookherjee, Vijender Chaitankar, S. Hiriyanna, Jung-Woong Kim, M. Brooks, Yasaman Ataeijannati, Xun Sun, Lijin Dong, Tiansen Li, A. Swaroop, Zhijian Wu   +11 more
semanticscholar   +1 more source

Generation of a Double Reporter mES Cell Line to Simultaneously Trace the Generation of Retinal Progenitors and Photoreceptors

Cells
Three-dimensional retinal culture systems help to understand eye development and the pathology of disorders. There is a need for reporter stem cell lines to allow in vitro studies on retinal progenitors and photoreceptors and their developmental dynamics
Oleksandr Zabiegalov, Adeline Berger, Dhryata Kamdar, Kabirou Adamou, Chuanxi Tian, Martial Mbefo, Mathieu Quinodoz, Florian Udry, Carlo Rivolta, Corinne Kostic, Yvan Arsenijevic   +10 more
doaj   +1 more source

Increased proteasomal activity supports photoreceptor survival in inherited retinal degeneration

Nature Communications, 2018
Inherited retinal degenerations, affecting more than 2 million people worldwide, are caused by mutations in over 200 genes. This suggests that the most efficient therapeutic strategies would be mutation independent, i.e., targeting common pathological ...
E. Lobanova, Stella Finkelstein, Jing Li, A. Travis, Y. Hao, Mikael Klingeborn, N. Skiba, R. Deshaies, V. Arshavsky   +8 more
semanticscholar   +1 more source

A novel small molecule chaperone of rod opsin and its potential therapy for retinal degeneration

Nature Communications, 2018
Rhodopsin homeostasis is tightly coupled to rod photoreceptor cell survival and vision. Mutations resulting in the misfolding of rhodopsin can lead to autosomal dominant retinitis pigmentosa (adRP), a progressive retinal degeneration that currently is ...
Yuanyuan Chen, Yu Chen, B. Jastrzebska, M. Golczak, S. Gulati, Hong Tang, W. Seibel, Xiaoyu Li, Hui Jin, Y. Han, Songqi Gao, Jianye Zhang, Xujie Liu, Hossein Heidari-Torkabadi, P. Stewart, W. Harte, G. Tochtrop, K. Palczewski   +17 more
semanticscholar   +1 more source

Incidence and Risk Factors of Iatrogenic Retinal Breaks: 20-Gauge versus 25-Gauge Vitrectomy for Idiopathic Macular Hole Repair

Journal of Ophthalmology, 2020
Purpose. We compared the incidences of iatrogenic retinal breaks and postoperative retinal detachment between eyes that underwent 20-gauge vitrectomy and those that underwent 25-gauge vitrectomy for idiopathic macular hole repair. Methods.
Norio Fujiwara, Goji Tomita, Fumihiko Yagi   +2 more
doaj   +1 more source

Genetic and clinical characteristics of PROM1-related retinal degeneration in Korean

Scientific Reports, 2023
This scientific report aims to comprehensively describe the genetic and clinical characteristics of PROM1-related retinal degeneration in Korean patients.
Sungsoon Hwang, Se Woong Kang, Ja-Hyun Jang, Sang Jin Kim   +3 more
doaj   +1 more source

Are Anti-Retinal Autoantibodies a Cause or a Consequence of Retinal Degeneration in Autoimmune Retinopathies?

Frontiers in Immunology, 2018
Autoantibodies (AAbs) against various retinal proteins have been associated with vision loss in paraneoplastic and non-paraneoplastic autoimmune retinopathies (AR).
G. Adamus
semanticscholar   +1 more source

Current and Future Cornea Chip Models for Advancing Ophthalmic Research and Therapeutics

Advanced Biology, EarlyView.
This review analyzes cornea chip technology as an innovative solution to corneal blindness and tissue scarcity. The examination encompasses recent developments in biomaterial design and fabrication methods replicating corneal architecture, highlighting applications in drug screening and disease modeling while addressing key challenges in mimicking ...
Minju Kim, Kanghoon Choi, Amy Lin, Jungkyu Kim   +3 more
wiley   +1 more source