Results 31 to 40 of about 9,860,660 (392)
Gene's hubs in retinal diseases: A retinal disease network [PDF]
Heliyon, 2018 Retinal diseases associated with the dysfunction or death of photoreceptors are a major cause of blindness around the world, improvements in genetics tools, like next generation sequencing (NGS) allows the discovery of genes and genetic changes that lead to many of those retinal diseases.
J.M. Lázaro-Guevara +7 more
openaire +3 more sources
A Review on Mesenchymal Stem Cells for Treatment of Retinal Diseases
Stem Cell Reviews and Reports, 2021 Mesenchymal Stem Cells (MSCs) have been studied extensively for the treatment of several retinal diseases. The therapeutic potential of MSCs lies in its ability to differentiate into multiple lineages and secretome enriched with immunomodulatory, anti ...
Sanjucta Adak +4 more
semanticscholar +1 more source
Therapeutic potential of co-enzyme Q10 in retinal diseases [PDF]
, 2017 Coenzyme Q10 (CoQ10) plays a critical role in mitochondrial oxidative phosphorylation by serving as an electron carrier in the respiratory electron transport chain.
Marcheggiani, Fabio +6 more
core +1 more source
RNA-based therapies in inherited retinal diseases
Therapeutic Advances in Ophthalmology, 2022 Inherited retinal diseases (IRDs) are a genetically and phenotypically heterogeneous group of genetic eye disorders. There are more than 300 disease entities, and together this group of disorders affects millions of people globally and is a frequent ...
A. Girach +11 more
semanticscholar +1 more source
Retinal imaging in inherited retinal diseases
Annals of Eye Science, 2020 Inherited retinal diseases (IRD) are a leading cause of blindness in the working age population. The advances in ocular genetics, retinal imaging and molecular biology, have conspired to create the ideal environment for establishing treatments for IRD, with the first approved gene therapy and the commencement of multiple therapy trials.
Georgiou, Michalis +2 more
openaire +2 more sources
Genetic testing and diagnosis of inherited retinal diseases
Orphanet Journal of Rare Diseases, 2021 Inherited retinal diseases (IRDs) are a diverse group of degenerative diseases of the retina that can lead to significant reduction in vision and blindness.
B. Lam +5 more
semanticscholar +1 more source
Photoreceptor Outer Segment-like Structures in Long-Term 3D Retinas from Human Pluripotent Stem Cells. [PDF]
, 2017 The retinal degenerative diseases, which together constitute a leading cause of hereditary blindness worldwide, are largely untreatable. Development of reliable methods to culture complex retinal tissues from human pluripotent stem cells (hPSCs) could ...
Angueyra, Juan M +9 more
core +1 more source
Gene Therapy in Inherited Retinal Diseases: An Update on Current State of the Art
Frontiers in Medicine, 2021 Background: Gene therapy cannot be yet considered a far perspective, but a tangible therapeutic option in the field of retinal diseases. Although still confined in experimental settings, the preliminary results are promising and provide an overall ...
A. Amato +6 more
semanticscholar +1 more source
In vivo volumetric imaging of human retinal circulation with phase-variance optical coherence tomography [PDF]
, 2011 We present in vivo volumetric images of human retinal micro-circulation using Fourier-domain optical coherence tomography (Fd-OCT) with the phase-variance based motion contrast method.
An +30 more
core +2 more sources
Metabolism Dysregulation in Retinal Diseases and Related Therapies
Antioxidants, 2022 The human retina, which is part of the central nervous system, has exceptionally high energy demands that requires an efficient metabolism of glucose, lipids, and amino acids.
Yingying Chen +8 more
semanticscholar +1 more source