Results 71 to 80 of about 277,755 (206)

Enhanced therapeutic effect of PEDF-loaded mesenchymal stem cell-derived small extracellular vesicles against oxygen-induced retinopathy through increased stability and penetrability of PEDF

Journal of Nanobiotechnology, 2023
Background Several common retinal diseases that cause blindness are characterised by pathological neovascularisation accompanied by inflammation and neurodegeneration, including retinopathy of prematurity (ROP), diabetic retinopathy (DR), age-related ...
Ruiyan Fan, Lin Su, Hui Zhang, Yilin Jiang, Zihao Yu, Xiaomin Zhang, Xiaorong Li   +6 more
doaj   +1 more source

Detection of multiple retinal diseases in ultra-widefield fundus images using deep learning: data-driven identification of relevant regions [PDF]

arXiv, 2022
Ultra-widefield (UWF) imaging is a promising modality that captures a larger retinal field of view compared to traditional fundus photography. Previous studies showed that deep learning (DL) models are effective for detecting retinal disease in UWF images, but primarily considered individual diseases under less-than-realistic conditions (excluding ...
arxiv  

Translational Retinal Research and Therapies. [PDF]

, 2018
The following review summarizes the state of the art in representative aspects of gene therapy/translational medicine and evolves from a symposium held at the School of Veterinary Medicine, University of Pennsylvania on November 16, 2017 honoring Dr ...
Aguirre, Gustavo D, Beltran, William A, Cideciyan, Artur V, Flannery, John G, Hardcastle, Alison J, Jacobson, Samuel G, Sahel, José-Alain, Sieving, Paul A   +7 more
core   +1 more source

The critical role of m6A methylation in the pathogenesis of Graves' ophthalmopathy

Eye and Vision, 2020
Purpose To investigate the role of N6-methyladenosine (m6A) RNA modification in the pathogenesis of Graves' ophthalmopathy (GO). Methods Surgically excised extraocular muscles from 7 patients with GO and 5 subjects without GO were used.
Li Zhu, Siyan Li, Shikun He, Qizhe Tong, Lejin Wang, Xiaohua Li, Xi Wu, Qingyu Meng, Enzhong Jin, Chuan Zhang, Tianyuan Li, Ningda Xu, Lvzhen Huang, Yi Wang, Mingwei Zhao   +14 more
doaj   +1 more source

The Role of Widefield Optical Coherence Tomography Angiography in Assessing the Severity of Diabetic Retinopathy

Ophthalmology and Therapy
Introduction Physicians need an accurate understanding of diabetic retinopathy (DR) severity to optimally manage patients. The aim of this prospective study is to correlate the severity of macular and peripheral retinal vascular abnormalities seen on ...
Deepika C. Parameswarappa, Amelia Janis Langstang, Sanagavarapu Kavya, Ashik Mohamed, Michael W. Stewart, Padmaja Kumari Rani   +5 more
doaj   +1 more source

Retina and glaucoma: surgical complications

International Journal of Retina and Vitreous, 2018
Background The close structural and microcirculatory co-relation between anterior and posterior segments of eye make them very vulnerable to complications when one of them is affected surgically.
Niroj Kumar Sahoo, Pasyanthi Balijepalli, Sumit Randhir Singh, Mahima Jhingan, Sirisha Senthil, Jay Chhablani   +5 more
doaj   +1 more source

Cholesterol oxidation in the retina: implications of 7KCh formation in chronic inflammation and age-related macular degeneration

Journal of Lipid Research, 2010
This review will discuss the formation and potential implications of 7-ketocholesterol (7KCh) in the retina. 7KCh is a proinflammatory oxysterol known to be present in high amounts in oxidized LDL deposits associated with atheromatous plaques.
Ignacio R. Rodríguez, Ignacio M. Larrayoz   +1 more
doaj  

Unmasking of molecular players: proteomic profiling of vitreous humor in pathologic myopia

BMC Ophthalmology
Background This study aimed to identify the differentially expressed proteins in the vitreous humor (VH) of eyes with and without pathologic myopia (PM), providing insights into the molecular pathogenesis.
Yue Wen, Chi Ren, Li Zhu, Lvzhen Huang, Huijun Qi, Wenzhen Yu, Kai Wang, Mingwei Zhao, Qiong Xu   +8 more
doaj   +1 more source

Recurrence of Retinopathy of Prematurity in Zone II Stage 3+ after Ranibizumab Treatment: A Retrospective Study

Journal of Ophthalmology, 2017
Objective. To determine the prevalence and risk factors for the recurrence of retinopathy of prematurity (ROP) in Zone II Stage 3+ after ranibizumab treatment. Methods. This was a retrospective, nonrandomized, noncontrolled study that excluded Zone I and
Qinrui Hu, Yujing Bai, Xiaoli Chen, Lvzhen Huang, Yi Chen, Xiaoxin Li   +5 more
doaj   +1 more source

Correction: PSF functions as a repressor of hypoxia-induced angiogenesis by promoting mitochondrial function

Cell Communication and Signaling, 2023
Lijie Dong, Wenbo Li, Tingting Lin, Boshi Liu, Yaru Hong, Xiaomin Zhang, Xiaorong Li   +6 more
doaj   +1 more source