Results 71 to 80 of about 1,953 (166)

Apolipoprotein Localization in Isolated Drusen and Retinal Apolipoprotein Gene Expression

Investigative Opthalmology & Visual Science, 2006
To evaluate apolipoprotein (Apo) gene expression in native human retinal pigment epithelium (RPE) and neurosensory retina and to detect apolipoproteins within age-related, extramacular drusen.Drusen were isolated manually from 10 eyes of 10 donors (age range, 58-93 years) with grossly normal maculas that were preserved in 4% paraformaldehyde within 6 ...
Chuan-Ming, Li, Mark E, Clark, Melissa F, Chimento, Christine A, Curcio   +3 more
openaire   +2 more sources

Decellularized Aged Bruch's Membrane Confers Unique Biochemical Cues to Retinal Pigment Epithelium for In Vitro Modeling of Age‐Related Macular Degeneration

Aging Cell, Volume 25, Issue 5, May 2026.
A Bruchs membrane (BrM) mimic based on aged decellularized BrM was developed and differentially expressed proteins in aged dECM‐BrM that may provide specific biochemical cues fundamental to model AMD in vitro were identified. RPE culture on aged dECM‐BrM developed certain AMD‐like features including reduced TEER and expression of drusen components ...
Blanca Molins, Mercedes Soledad Nabaes Jodar, Eliandre de Oliveira, Josep Maria Estanyol, Esther Peña, Jaione Bezunartea, María Hernández, Marc Figueras‐Roca, Alfredo Adan   +8 more
wiley   +1 more source

Association of drusen deposition with choroidal intercapillary pillars in the aging human eye

, 2004
PURPOSE. To determine the pattern of drusen accumulation with age and to investigate the initial sites of deposition and their relationship to choroidal capillaries in human donor eyes from the eye bank of Moorfields Eye Hospital.METHODS.
Al Hosaini, H, Bird, AC, Tufail, A, Jeffery, G, Luthert, P, Lengyel, I   +5 more
core  

Diagnosing Optic Disc Drusen in the Modern Imaging Era:A Practical Approach

, 2021
Optic disc drusen (ODD) are a well-recognised cause of an elevated optic disc appearance. When visible with ophthalmoscopy and fundus photography, ODD are readily identified. Yet, in more subtle cases of ODD, ancillary testing may be needed to render the
Sibony, P. A., Rothenbuehler, S. P., Hamann, S., Costello, F., the Optic Disc Drusen Studies Consortium, Optic Disc Drusen Studies Consortium   +4 more
core   +1 more source

Unilateral Acute Anterior Ischemic Optic Neuropathy in a Patient with an Already Established Diagnosis of Bilateral Optic Disc Drusen

Case Reports in Ophthalmological Medicine, 2015
Optic disc drusen (ODD) are calcific deposits that form in the optic nerve head secondary to abnormalities in axonal metabolism and degeneration. Anterior ischemic optic neuropathy, central retinal artery, and vein occlusion are among the rare vascular ...
Ziya Ayhan, Aylin Yaman, Meltem Söylev Bajin, A. Osman Saatci   +3 more
doaj   +1 more source

Complete Regression of bilateral Choroidal Metastases secondary to a Cutaneous Melanoma under Immunotherapy

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Yenny Angela, Alena Riesmeier, Ralf Gutzmer, Miltiadis Fiorentzis, Nikolaos E. Bechrakis, Carsten Framme, Ekaterina Sokolenko   +6 more
wiley   +1 more source

Power and clinical utility of mesopic microperimetry analysis strategies in age‐related macular degeneration

Acta Ophthalmologica, Volume 104, Issue 3, Page e292-e299, May 2026.
Abstract Purpose This study evaluates whether mesopic microperimetry (MMP) provides a more robust measure of retinal function compared to visual acuity (VA) in age‐related macular degeneration (AMD) clinical trials, with a focus on optimal analysis strategies. Method Fellow‐eyes of unilateral neovascular AMD were prospectively studied.
Francesco Cinque, Jeroen Pas, Mahfam Shahabi, Laurens Sluijterman, Sofie ten Brink, Anita de Breuk, Thomas J. Heesterbeek, Caroline Klaver, Carel Hoyng, Yara Lechanteur   +9 more
wiley   +1 more source

Identification of hydroxyapatite spherules provides new insight into subretinal pigment epithelial deposit formation in the aging eye.

, 2015
Accumulation of protein- and lipid-containing deposits external to the retinal pigment epithelium (RPE) is common in the aging eye, and has long been viewed as the hallmark of age-related macular degeneration (AMD).
Flinn, JM, Lanzirotti, A, McPhail, DS, Fearn, S, Ueffing, M, Boldt, K, Ratu, SG, Lengyel, I, Thompson, RB, Kortvely, E, Pauleikhoff, L, Bird, AC, Reffatto, V, Bundy, JG, Jones, EA   +14 more
core  

Prevalence of retinal pathologies in people over 60 years: the Tehran Geriatrics Eye Study [PDF]

International Journal of Ophthalmology
AIM: To determine the prevalence of some retinal pathologies in people over 60y and their association with demographic and ocular factors. METHODS: A cross-sectional study was conducted in Tehran using multistage cluster sampling.
Abolghasem Mortazavi, Alireza Hashemi, Alirerza Jamali, Hassan Hashemi, Mohammadreza Aghamirsalim, Mehdi Khabazkhoob   +5 more
doaj   +1 more source

Neovascular age‐related macular degeneration without drusen

Acta Ophthalmologica, Volume 104, Issue 3, Page e300-e311, May 2026.
Abstract Purpose To describe the clinical characteristics and 1‐year follow‐up of patients with neovascular AMD (nAMD) without drusen in either eye. Methods This is a multicentre retrospective cohort study in three tertiary referral centres in The Netherlands. We included patients of 55 years or older with nAMD in one or both eyes, without the presence
Marc J. Sirks, Elon H. C. van Dijk, Husein Ghalayini, Somayeh Bazdar, WeiFeng Yu, Suzanne Yzer, José P. Martinez Ciriano, Reinier O. Schlingemann, Roselie M. H. Diederen, Camiel J. F. Boon   +9 more
wiley   +1 more source