Results 61 to 70 of about 1,953 (166)

Histologic and Morphometric Comparison of Drusen Associated With Chronic Retinal Detachment and Aging-Associated Drusen

Translational Vision Science & Technology
Drusen are subretinal pigment epithelium extracellular matrix deposits. This study compared histomorphometric characteristics of age-related and atypical drusen found in an eye of a young woman with chronic retinal detachment (RD).We conducted a histomorphometric examination of drusen identified in 3 eyes: an eviscerated eye from a 35-year-old woman ...
Nisanova, Arina, Lin, Jonathan H., Frauches, Rachel L., Estrada, Martin, Nelson, Andrew J.   +4 more
openaire   +3 more sources

The m.14484T>C MT‐ND6 Mutation Presenting with a Hereditary Spastic‐Paraparesis Phenotype

Movement Disorders Clinical Practice, EarlyView.
Gabriel Amorelli, Christelle Nilles, Gerald Pfeffer, Matthew Joel, Davide Martino   +4 more
wiley   +1 more source

Retinal disease classification from OCT images using EfficientNetB3 with neutrosophic similarity score enhancement

Journal of Applied Clinical Medical Physics, Volume 27, Issue 5, May 2026.
Abstract Purpose Automated classification of retinal diseases from optical coherence tomography (OCT) images plays a significant role in supporting early diagnosis and clinical decision‐making. In this study, a deep learning (DL) framework is developed by integrating a neutrosophic similarity score (NSS) with the EfficientNetB3 to improve image ...
Devi M, G. Hannah Grace
wiley   +1 more source

Safety, Tolerability, and Pharmacokinetics of Mirvetuximab Soravtansine in Chinese Patients With Folate Receptor α‐Positive Advanced Ovarian Cancer

Cancer Medicine, Volume 15, Issue 5, May 2026.
ABSTRACT Background Folate receptor α (FRα) is a glycosylphosphatidylinositol‐anchored protein that facilitates folate transport and has emerged as a promising therapeutic target for ovarian cancer, particularly due to its association with tumor progression.
Yongsheng Li, Li Yuan, Ge Lou, Hongbing Cai, Yuzhi Li, Fenghu Li, Li Wang, Xingtao Long, Yi Gong, Chaonan Zhu, Li Li, June Xu, Qi Zhou   +12 more
wiley   +1 more source

Transmission Electron Microscopy Data on drusen-like deposits in the retinal degeneration sTg-IRBP: HEL mouse model

Data in Brief, 2019
Histology (H&E) and transmission electron microscopy (TEM) data are provided showing age-related changes in the retinal structure of sTg-IRBP:HEL mice.
Yi-Hsia Liu, Christine Mölzer, Gillian C. Milne, Lucia Kuffová, John V. Forrester   +4 more
doaj   +1 more source

BiOrthoNet: Efficient Retinal OCT Classification Using Direction‐Specific Convolutions

International Journal of Imaging Systems and Technology, Volume 36, Issue 3, May 2026.
ABSTRACT Reliable interpretation of optical coherence tomography (OCT) scans is crucial for the early detection of retinal diseases. Deep learning has emerged as a promising approach for this task; however, many existing models are computationally intensive and fail to exploit the horizontal‐vertical structural organization commonly observed in retinal
Ezzaldeen H. A. Abukhattab, Turgay Batbat   +1 more
wiley   +1 more source

Multiple logistic regression analysis and associated factors for retinal drusen.

, 2016
Multiple logistic regression analysis and associated factors for retinal drusen.
Nobuhiro Shimozawa (692094), Yu Yokoyama (577508), Fumiko Ono (3239598), Mutsumi Togo (3239592), Koji M. Nishiguchi (147632), Toshinori Furukawa (3239595), Michihiro Suzuki (3175443), Toru Nakazawa (287792), Kosuke Fujita (836429), Ryo Kawasaki (438380), Yusuke Fujii (586973), Yusuke Tomiyama (2816728)   +11 more
core   +1 more source

Analysis of Macular Drusen and Blood Test Results in 945 Macaca fascicularis. [PDF]

PLoS ONE, 2016
Age-dependent formation of macular drusen caused by the focal accumulation of extracellular deposits beneath the retinal pigment epithelium precede the development of age-related macular degeneration (AMD), one of the leading causes of blindness ...
Koji M Nishiguchi, Yu Yokoyama, Yusuke Fujii, Kosuke Fujita, Yusuke Tomiyama, Ryo Kawasaki, Toshinori Furukawa, Fumiko Ono, Nobuhiro Shimozawa, Mutsumi Togo, Michihiro Suzuki, Toru Nakazawa   +11 more
doaj   +1 more source

Photodegradable Hydrogels for On‐Demand Modeling of Age‐Related Spatiotemporal ECM Deformation

Small, Volume 22, Issue 27, 14 May 2026.
A light‐tunable PEG hydrogel enables on‐demand, spatiotemporal modeling of drusen‐like ECM bulges in the aging outer retina. By precisely controlling bulge size, the platform reveals how retinal pigment epithelium morphology adapts to topographical changes without disrupting actin cytoskeleton or polarity, effectively mimicking early ageing before ...
Felix Reul, Cédric Bergerbit, Iulia Scarlat, Teodora Piskova, Vasudha Turuvekere Krishnamurthy, Aleksandra N. Kozyrina, Stacy Lok Sze Yam, Laura De Laporte, Jacopo Di Russo   +8 more
wiley   +1 more source

Amyloid β peptides overexpression in retinal pigment epithelial cells via AAV-mediated gene transfer mimics AMD-like pathology in mice

Scientific Reports, 2017
Age-related macular degeneration (AMD) is a progressive retinal neurodegenerative disorder characterized by extracellular deposits known as drusen. A major constituent of drusen deposits are Alzheimer disease-associated amyloid β (Aβ) peptides.
Tuhina Prasad, Ping Zhu, Amrisha Verma, Paramita Chakrabarty, Awilda M. Rosario, Todd E. Golde, Qiuhong Li   +6 more
doaj   +1 more source