Results 221 to 230 of about 119,076 (326)

FK962 protects retinal ganglion cell under hypoxia/reoxygenation: Possible involvement of glial cell line-derived neurotrophic factor signaling pathway

Momoko Kobayashi-Otsugu, Yayoi Kishimoto, Mitsuyoshi Azuma, Chiho Fukiage   +3 more
openalex   +1 more source

Transplanted Mouse Embryonic Stem Cell–Derived Retinal Ganglion Cells Integrate and Form Synapses in a Retinal Ganglion Cell-Depleted Mouse Model

, 2021
You‐Ren Wu, Tomoyo Hashiguchi, Junki Sho, Shih‐Hwa Chiou, Masayo Takahashi, Michiko Mandai   +5 more
openalex   +1 more source

Genetic Pigmentary Disorders: From Molecular Mechanisms to Clinical Manifestations

The Journal of Dermatology, Volume 53, Issue 2, Page 169-179, February 2026.
ABSTRACT Genetic pigmentary disorders represent a diverse group of genetic conditions characterized by alterations in melanin production and transport and melanocyte development, resulting from single‐gene pathological variants. These disorders encompass both hypopigmentary and hyperpigmentary phenotypes, affecting not only skin pigmentation but also ...
Ken Okamura, Tamio Suzuki
wiley   +1 more source

ATF3 prevents retinal ganglion cell apoptosis and mitigates microglia-mediated neuroinflammation in retinal ischemia-reperfusion injury. [PDF]

Front Immunol
Zhang N, Tian T, Wang Z, He X, Cao W, Zhang W, Xing Y, Yang N.   +7 more
europepmc   +1 more source

NMNAT1 Activates Autophagy to Delay D‐Galactose‐Induced Aging in Cochlear Hair Cells

Aging Cell, Volume 25, Issue 2, February 2026.
The study presents mechanistic insights into cochlear hair cells aging using cellular and explant models. The assessment into NMNAT1 regulated NAD+ metabolism, autophagy, and aging in ARHL. NMNAT1 overexpression restores autophagic activity and decelerates aging in cochlear hair cells.
Yongjie Wei, Wenqing Yang, Han Wu, Mengdie Kong, Dachuan Fan, Yuhua Zhang, Nan Cheng, Jiawei Du, Lingna Guo, Yuyang Li, Ye Zhang, Qian Dai, Wei Cao, Jianming Yang, Qiaojun Fang   +14 more
wiley   +1 more source

Soluble guanylate cyclase deficiency drives retinal ganglion cell neurodegeneration with age in female mice through disrupted oxidative metabolism. [PDF]

Sci Rep
Bossardet OL, Clark KL, Wade S, Snyder LA, Mecca S, Holden JM, Almaoui E, Konety R, Ghanem GOB, Korobkina ED, Rex TS, Wareham LK.   +11 more
europepmc   +1 more source

MSC‐Derived Exosomal lnc‐AGT‐3: A Novel Anti‐Angiogenic Target in Age‐Related Macular Degeneration Through p53 Signaling Pathway

Aging Cell, Volume 25, Issue 2, February 2026.
MSC‐derived exosomes deliver lnc‐AGT‐3 to vascular endothelial cells, where it binds hnRNP K in the nucleus. This interaction inhibits p53 ubiquitination, enhancing p53 stabilization and transcriptional activation of anti‐angiogenic targets TSP1. Consequently, p53‐mediated signaling is potentiated, effectively suppressing choroidal neovascularization ...
Lingjie Kong, Xiaoyan Han, Siyi Qi, Duo Li, Jingyue Zhang, Linyu Zhang, Shujie Zhang, Qin Jiang, Biao Yan, Chen Zhao   +9 more
wiley   +1 more source

Retinal ganglion cell loss is associated with multimodal visual dysfunction following demyelinating optic neuritis. [PDF]

Mult Scler J Exp Transl Clin
Subhi M, Manukyan S, Zabala G, Locke L, Guerrero B, Kaisey M, Khodabakhsh AJ, Carass A, Prince JL, Saidha S, Calabresi PA, Sicotte NL, Sati P, Al-Louzi O.   +13 more
europepmc   +1 more source

Test–retest variability of the full‐field stimulus test in patients with retinitis pigmentosa: REPEAT Study Report No. 4

Acta Ophthalmologica, Volume 104, Issue 1, Page 89-97, February 2026.
Abstract Purpose To evaluate test–retest variability (TRV) of the full‐field stimulus test (FST) in patients with retinitis pigmentosa (RP) and poor best‐corrected visual acuity (BCVA; ≤20/50 Snellen; ≥0.40 logMAR), and to assess the reliability of FST as a clinical endpoint in future RP trials.
J. S. Karuntu, S. B. A. E. Tulp, C. J. F. Boon   +2 more
wiley   +1 more source

ON and OFF retinal ganglion cells differentially regulate serotonergic and GABAergic activity in the dorsal raphe nucleus

, 2016
Ting Zhang, Lu Huang, Li Zhang, Minjie Tan, Mingliang Pu, Gary E. Pickard, Kwok‐Fai So, Chaoran Ren   +7 more
openalex   +1 more source