Results 251 to 260 of about 72,734 (313)

Shifting From Systemic to Precision‐Targeted Complement Therapies: Opportunities and Hurdles

European Journal of Immunology, Volume 56, Issue 6, June 2026.
Complement therapeutics have expanded considerably, but systemic inhibitors remain limited by infection risks, breakthrough events, and loss of physiological functions. Emerging targeted approaches aim for organ‐, tissue‐, or cell‐specific modulation of complement activity, potentially offering greater precision while reducing treatment burden and ...
Marco Mannes, Wioleta M. Zelek, Leendert A. Trouw   +2 more
wiley   +1 more source

MKK4 and MKK7 control degeneration of retinal ganglion cell somas and axons after glaucoma-relevant injury. [PDF]

Cell Death Discov
Marola OJ, Syc-Mazurek SB, Yablonski SER, Shrager PG, John SWM, Libby RT.   +5 more
europepmc   +1 more source

Brain–Computer Interfaces: The Dawn of a New Era in Disease Treatment

Exploration, Volume 6, Issue 3, June 2026.
This study investigates the potential of brain–computer interface (BCI) technology in treating neuropsychiatric disorders, such as movement and communication barriers. Our review examines the history, signal paradigms, and diverse applications of BCI while also discussing ongoing research into novel materials and emerging technologies that offer ...
Yuqi Feng, Wangzheqi Zhang, Jun Chen, Huang Wu, Lei Wu, Yanhao Qiu, Xiaoming Deng, Chenglong Zhu, Yisheng Chen, Zhijie Zhao, Changli Wang, Xiaomin Zhang   +11 more
wiley   +1 more source

Dasatinib and Quercetin Alleviate Retinal Ganglion Cell Dendritic Shrinkage and Promote Axonal Regeneration in Mice with Optic Nerve Injury. [PDF]

Int J Mol Sci
Bin X, Zhou S, Xu Y, Chen S, Chen S, Yao W, Cao Y, Qiu K, Ng TK.   +8 more
europepmc   +1 more source

Biomaterial Physical Cues as Gene Regulators for Cellular Agriculture

Advanced Genetics, Volume 7, Issue 2, June 2026.
This review elucidates how biomaterial physical cues—ranging from matrix stiffness to remote electromagnetic fields—serve as extrinsic regulators of gene expression in cellular agriculture. By identifying central mechanotransduction pathways that bridge physical inputs to genetic remodeling, the authors propose the “Material Genome” concept: a ...
Jianuo Liu, Ye Liu
wiley   +1 more source

Soluble guanylate cyclase deficiency drives retinal ganglion cell neurodegeneration with age in female mice through disrupted oxidative metabolism. [PDF]

Sci Rep
Bossardet OL, Clark KL, Wade S, Snyder LA, Mecca S, Holden JM, Almaoui E, Konety R, Ghanem GOB, Korobkina ED, Rex TS, Wareham LK.   +11 more
europepmc   +1 more source

Spleen Tyrosine Kinase (SYK) is Necessary for cGAS‐STING Signaling in Müller Glia and Visual Function Deficits in Diabetic Mice

Glia, Volume 74, Issue 6, June 2026.
Hyperglycemic conditions increased mitochondrial membrane permeability and inflammatory signaling in Müller cells via cGAS‐STING activation. SYK was necessary for cGAS–STING activation and increased cytokine expression in Müller cells. Müller glia‐specific SYK deletion reduced glial activation and attenuated inflammatory cytokine expression in the ...
Esma I. Yerlikaya, Siddharth Sunilkumar, Sandeep M. Subrahmanian, Allyson L. Toro, Clay T. Yeager, Kashif A. Shaikh, Edward W. Harhaj, Alistair J. Barber, Michael D. Dennis   +8 more
wiley   +1 more source

Disease modeling of myocilin mutation-dependent normal tension glaucoma: human retinal ganglion cell susceptibility to unfolded protein response and mTOR signaling. [PDF]

Stem Cells
Shil SK, Subramani M, Van Hook MJ, Qiu F, Ahmad I.   +4 more
europepmc   +1 more source

A Dynamic Change of Microglial States Occurs During the Transition From Photoreceptor Degeneration to Regeneration in Zebrafish pde6c Mutants

Glia, Volume 74, Issue 6, June 2026.
Zebrafish pde6c mutants undergo photoreceptor degeneration from 5 dpf, but rods regenerate from 4 wpf. scRNA‐seq of retinal microglia reveals dynamic change of states between 5 dpf and 4 wpf. Two states emerge specifically during regeneration. ABSTRACT Microglia, brain‐resident immune cells, maintain brain homeostasis.
Darshini Ravishankar, Yuki Takeuchi, Ichiro Masai   +2 more
wiley   +1 more source

Prophylactic self-assembled nucleic acid hydrogel targeting retinal ganglion cell cuproptosis and microglial neuroinflammation for retinal ischemia-reperfusion injury. [PDF]

Bioact Mater
Liu S, Wang Z, Wu Y, Ju Y, Tang Z, Zhang D, Chen X, Wang N, Song M, Gu C, Liu Y, Guo W, Zhang J, Xiao C, Lu L, Zhang C, Ni N, Gu P.   +17 more
europepmc   +1 more source