Results 51 to 60 of about 103,275 (189)
Molecular Therapy: Methods & Clinical Development, 2017 Retinal ganglion cell degeneration triggered by axonal injury is believed to underlie many ocular diseases, including glaucoma and optic neuritis. In these diseases, retinal ganglion cells are affected unevenly, both spatially and temporally, such that ...
Kosuke Fujita +3 more
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Drug Discovery Strategies for Inherited Retinal Degenerations
Biology, 2022 Inherited retinal degeneration is a group of blinding disorders afflicting more than 1 in 4000 worldwide. These disorders frequently cause the death of photoreceptor cells or retinal ganglion cells.
Arupratan Das, Yoshikazu Imanishi
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Axonal mitophagy in retinal ganglion cells
Cell Communication and SignalingNeurons, exhibiting unique polarized structures, rely primarily on the mitochondrial production of ATP to maintain their hypermetabolic energy requirements. To maintain a normal energy supply, mitochondria are transported to the distal end of the axon. When mitochondria within the axon are critically damaged beyond their compensatory capacity, they are
Yang Liang +7 more
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Time-dependent maximum entropy model for populations of retinal ganglion cells [PDF]
arXiv, 2022 The inverse Ising model is used in computational neuroscience to infer probability distributions of the synchronous activity of large neuronal populations. This method allows for finding the Boltzmann distribution with single neuron biases and pairwise interactions that maximizes the entropy and reproduces the empirical statistics of the recorded ...
arxiv
Effects of tACS-Like Electrical Stimulation on Correlated Firing of Retinal Ganglion Cells: Part III
Eye and Brain, 2022 Franklin R Amthor, Christianne E Strang Department of Psychology, The University of Alabama at Birmingham, Birmingham, AL, 35294, USACorrespondence: Franklin R AmthorDepartment of Psychology, The University of Alabama at Birmingham, 1300 University Blvd,
Amthor FR, Strang CE
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Frontiers in Neuroscience, 2023 IntroductionUnderstanding the retina in health and disease is a key issue for neuroscience and neuroengineering applications such as retinal prostheses.
Aiwen Xu +2 more
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Effects of Iron and Zinc on Mitochondria: Potential Mechanisms of Glaucomatous Injury
Frontiers in Cell and Developmental Biology, 2021 Glaucoma is the most substantial cause of irreversible blinding, which is accompanied by progressive retinal ganglion cell damage. Retinal ganglion cells are energy-intensive neurons that connect the brain and retina, and depend on mitochondrial ...
Jiahui Tang, Yehong Zhuo, Yiqing Li
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Hypothermia Protects and Prolongs the Tolerance Time of Retinal Ganglion Cells against Ischemia. [PDF]
PLoS ONE, 2016 PURPOSE:Hypothermia has been shown to be neuroprotective in the therapy of ischemic stroke in the brain. To date no studies exist on the level of the inner retina and it is unclear if hypothermia would prolong the ischemic tolerance time of retinal ...
Maximilian Schultheiss +9 more
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Molecular Phenotyping of Retinal Ganglion Cells [PDF]
The Journal of Neuroscience, 2002 Classifying all of the ganglion cells in the mammalian retina has long been a goal of anatomists, physiologists, and cell biologists. The rabbit retinal ganglion cell layer was phenotyped using intrinsic small molecule signals (aspartate, glutamate, glycine, glutamine, GABA, and taurine) and glutamate receptor-gated 1-amino-4-guanidobutane excitation ...
Bryan W. Jones, Robert E. Marc
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Cell based therapies for glaucoma
Advances in Clinical Neuroscience & Rehabilitation, 2016 Stem cells could be useful in the treatment of glaucoma by improving aqueous outflow to lower eye pressure, by protecting retinal ganglion cells directly against glaucoma damage or by facilitating optic nerve regeneration.
Craig Pearson, Keith Martin
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