Results 81 to 90 of about 103,275 (189)
Acta Neuropathologica CommunicationsLeber’s hereditary optic neuropathy (LHON) is driven by mtDNA mutations affecting Complex I presenting as progressive retinal ganglion cell dysfunction usually in the absence of extra-ophthalmic symptoms. There are no long-term neuroprotective agents for
Amin Otmani +4 more
doaj +1 more source
Extreme Synergy in a Retinal Code: Spatiotemporal Correlations Enable Rapid Image Reconstruction [PDF]
arXiv, 2007 Over the brief time intervals available for processing retinal output, roughly 50 to 300 msec, the number of extra spikes generated by individual ganglion cells can be quite variable. Here, computer-generated spike trains were used to investigate how signal/noise might be improved by utilizing spatiotemporal correlations among retinal neurons ...
arxiv
Optogenetic vision restoration with high resolution [PDF]
arXiv, 2018 The majority of inherited retinal degenerations are due to photoreceptor cell death. In many cases ganglion cells are spared making it possible to stimulate them to restore visual function. Several studies (Bi et al., 2006; Lin et al., 2008; Sengupta et al., 2016; Caporale et al., 2011; Berry et al., 2017) have shown that it is possible to express an ...
arxiv
Neural Ganglion Sensors: Learning Task-specific Event Cameras Inspired by the Neural Circuit of the Human Retina [PDF]
arXivInspired by the data-efficient spiking mechanism of neurons in the human eye, event cameras were created to achieve high temporal resolution with minimal power and bandwidth requirements by emitting asynchronous, per-pixel intensity changes rather than conventional fixed-frame rate images. Unlike retinal ganglion cells (RGCs) in the human eye, however,
arxiv
Acta Neuropathologica CommunicationsA compromised capacity to maintain NAD pools is recognized as a key underlying pathophysiological feature of neurodegenerative diseases. NAD acts as a substrate in major cell functions including mitochondrial homeostasis, cell signalling, axonal ...
Gloria Cimaglia +4 more
doaj +1 more source
Optimizing Retinal Prosthetic Stimuli with Conditional Invertible Neural Networks [PDF]
arXivImplantable retinal prostheses offer a promising solution to restore partial vision by circumventing damaged photoreceptor cells in the retina and directly stimulating the remaining functional retinal cells. However, the information transmission between the camera and retinal cells is often limited by the low resolution of the electrode array and the ...
arxiv
Neural Regeneration ResearchDiabetic retinopathy is a prominent cause of blindness in adults, with early retinal ganglion cell loss contributing to visual dysfunction or blindness.
Yu-Qi Shao +8 more
doaj +1 more source
Fast computation of the statistical significance test for spatio-temporal receptive field estimates obtained using spike-triggered averaging of binary pseudo-random sequences [PDF]
arXivBackground: Spatio-temporal receptive fields (STRF) of visual neurons are often estimated using spike-triggered averaging of binary pseudo-random stimulus sequences. The stimuli are visual displays that contain black and white pixels that flicker randomly at a fixed frame rate without any spatial or temporal correlation.
arxiv
Acta Neuropathologica CommunicationsNeurodegenerative diseases have common underlying pathological mechanisms including progressive neuronal dysfunction, axonal and dendritic retraction, and mitochondrial dysfunction resulting in neuronal death.
Anne Rombaut +8 more
doaj +1 more source