Results 91 to 100 of about 5,405,992 (262)
Scientific Reports, 2017 A photoreceptor cell line, 661W, derived from a mouse retinal tumor that expresses several markers of cone photoreceptor cells has been described earlier. However, these cells can be differentiated into neuronal cells. Here, we report that this cell line
Zuberwasim Sayyad +3 more
doaj +1 more source
Towards a Compositional Framework for Describing Human Phenotypes
Advanced Science, EarlyView.The Phenotype Assembly Method (PhenoAM) decomposes phenotype variables into measurable Features and typed Qualifiers, enabling standardized, machine‐readable Phenome Data Elements (PhenoDEs) that preserve measurement context. Applied in the International Human Phenome Project (IHPP), the framework yields 58 371 PhenoDEs and supports component‐level ...
Wanting Hu +11 more
wiley +1 more source
Cell based therapies for glaucoma
Advances in Clinical Neuroscience & Rehabilitation, 2016 Stem cells could be useful in the treatment of glaucoma by improving aqueous outflow to lower eye pressure, by protecting retinal ganglion cells directly against glaucoma damage or by facilitating optic nerve regeneration.
Craig Pearson, Keith Martin
doaj +1 more source
Retinal Ganglion Cell Loss in Diabetes Associated with Elevated Homocysteine
, 2009 A number of studies have suggested that homocysteine may be a contributing factor to development of retinopathy in diabetic patients based on observed correlations between elevated homocysteine levels and the presence of retinopathy.
Kenneth S. Shindler
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Gene expression analysis during retinal ganglion cell development [PDF]
, 2015 Retinal ganglion cells are the final output neurons that gather electrical signals from light-sensing cells and relay this information to discrete locations in the brain. The loss of ganglion cells due to cell death is an irreversible process in glaucoma.
Wester, Andrea
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Advanced Science, EarlyView.A blue‐light‐crosslinked bilayer hydrogel was developed for local optic nerve repair. The adhesive GM‐Odex outer layer seals and anchors the lesion, while the non‐adhesive GM‐imid inner layer releases MPDA‐Cle without obstructing CSF flow. This system modulates oxidative and inflammatory microenvironments, supports oligodendrocyte differentiation and ...
Tonghe Pan +13 more
wiley +1 more source
Molecular Biology of Retinal Ganglion Cells [PDF]
Cells, 2020 The main goal of this thematic issue was to bring both original research papers and reviews together to provide an insight into the rather broad topic of molecular biology of retinal ganglion cells (RGCs) [...]
openaire +3 more sources
Hypoxia-ischemia and retinal ganglion cell damage
, 2008 Charanjit Kaur1, Wallace S Foulds2, Eng-Ang Ling11Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; 2Singapore Eye Research Institute, SingaporeAbstract: Retinal hypoxia is the potentially blinding ...
Eng-Ang Ling +2 more
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Advanced Science, EarlyView.Ocular hypertension induces early hyperactivity in inner retinal inhibitory circuitry before substantial retinal ganglion cell loss. Sustained pharmacological inhibition of GABAergic/glycinergic neurotransmission and Vgat‐targeted Lin28 expression suppress this hyperactivity and improve RGC survival without reducing intraocular pressure. These findings
Eunji Hong +7 more
wiley +1 more source
Brimonidine prevents axonal and somatic degeneration of retinal ganglion cell neurons
Molecular Neurodegeneration, 2011 Background Brimonidine is a common drug for lowering ocular pressure and may directly protect retinal ganglion cells in glaucoma. The disease involves early loss of retinal ganglion cell transport to brain targets followed by axonal and somatic ...
Crish Samuel D +4 more
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