Results 61 to 70 of about 68,022 (253)

Tonicity response element binding protein associated with neuronal cell death in the experimental diabetic retinopathy [PDF]

, 2014
AIM: To study the contribution of tonicity response element binding protein (TonEBP) in retinal ganglion cell (RGC) death of diabetic retinopathy (DR). METHODS: Diabetes was induced in C57BL/6 mice by five consecutive intraperitoneal injections of 55 mg/
Choi, Wan-Sung, Chung, Inyoung, Kim, Hwajin, Kim, Seong-Jae, Kwon, H. Moo, Park, Jeongsook, Yoo, Ji-Myong   +6 more
core   +2 more sources

Unlocking Photodetection Mode Switching from a Simple Lateral Design

Advanced Functional Materials, EarlyView.
A simple lateral 2D perovskite photodetector capable of switching among transient, continuous, and dual transient/continuous photoresponse modes is achieved by integrating photoconductive effects with capacitive coupling from the SiO2/Si substrate. Such light‐programmable photodetection mode switching enables triple‐channel information transmission and
Zijun (June) Yong, Keng‐Te Lin, Joel van Embden, Taimur Ahmed, Yumeng Du, Dashen Dong, Yiwen Mai, Junlin Lu, Sumeet Walia, Baohua Jia, Tianyi Ma   +10 more
wiley   +1 more source

Monitoring retinal changes with optical coherence tomography predicts neuronal loss in experimental autoimmune encephalomyelitis. [PDF]

, 2019
BACKGROUND:Retinal optical coherence tomography (OCT) is a clinical and research tool in multiple sclerosis, where it has shown significant retinal nerve fiber (RNFL) and ganglion cell (RGC) layer thinning, while postmortem studies have reported RGC loss.
Aktas, Orhan, Albrecht, Philipp, Balk, Lisanne J, Cordano, Christian, Cruz-Herranz, Andrés, Dietrich, Michael, Fischer, Dietmar, Green, Ari J, Hallenberger, Angelika, Hartung, Hans-Peter, Hecker, Christina, Hilla, Alexander M, Ingwersen, Jens, Issberner, Andrea, Lehmann-Horn, Klaus, Levin, Marc H, von Gall, Charlotte, Yiu, Hao H, Zamvil, Scott S   +18 more
core   +1 more source

Aptamer‐Based Delivery Systems for VEGF and NGF Modulation in Ocular Therapies

Advanced Healthcare Materials, EarlyView.
Aptamer‐based delivery systems targeting NGF and VEGF hold significant potential for precise and sustained treatment of complex diseases affecting both the anterior and posterior segments of the eye. This review critically summarizes current strategies for NGF and VEGF delivery as well as VEGF sequestration, providing a clinical perspective on how ...
Nadine Best, Gizem Karabiyik, Gerd Geerling, Sarah Barbara Zwingelberg, Gregor Lang, Martin Humenik   +5 more
wiley   +1 more source

Significant changes in endogenous retinal gene expression assessed 1 year after a single intraocular injection of AAV-CNTF or AAV-BDNF

Molecular Therapy: Methods & Clinical Development, 2016
Use of viral vectors to deliver therapeutic genes to the central nervous system holds promise for the treatment of neurodegenerative diseases and neurotrauma.
Chrisna J LeVaillant, Anil Sharma, Jill Muhling, Lachlan PG Wheeler, Greg S Cozens, Mats Hellström, Jennifer Rodger, Alan R Harvey   +7 more
doaj   +1 more source

OCT and retinal ganglion cell layer

Acta Ophthalmologica, 2017
SummaryVision is highly dependent on both retinal ganglion cells (RGC) and their axons. Vision salvation depends on the prevention of RGC loss, and the time window to initiate a neuroprotective therapy after injury is not well defined in humans.Recent developments in both OCT technology and software have allowed a precise and reproducible assessment of
openaire   +1 more source

Neuromorphic Electronics for Intelligence Everywhere: Emerging Devices, Flexible Platforms, and Scalable System Architectures

Advanced Materials, EarlyView.
The perspective presents an integrated view of neuromorphic technologies, from device physics to real‐time applicability, while highlighting the necessity of full‐stack co‐optimization. By outlining practical hardware‐level strategies to exploit device behavior and mitigate non‐idealities, it shows pathways for building efficient, scalable, and ...
Kapil Bhardwaj, Roshni Satheesh Babu, Yuxin Xia, Eva Bestelink, Radu Sporea, Nikos Hastas, Ioannis Zeimpekis, Dimitra G. Georgiadou, Sayani Majumdar   +8 more
wiley   +1 more source

Analysis of macular structure in age-related cataract patients with different antibody levels of severe acute respiratory syndrome coronavirus-2 vaccine

Frontiers in Immunology, 2022
ObjectiveTo analyze the macular structure of age-related cataract (ARC) patients with different antibody levels after COVID-19 vaccine injection, in order to obtain the effect of COVID-19 vaccine on the macular structure, and speculate whether the COVID ...
Xiaochun Li, Xiaochun Li, Xiaoguang Cao, Zhongting Pan, Xinping Sun, Yongzhen Bao   +5 more
doaj   +1 more source

Spleen Tyrosine Kinase (SYK) is Necessary for cGAS-STING Signaling in Müller Glia and Visual Function Deficits in Diabetic Mice. [PDF]

Glia
Hyperglycemic conditions increased mitochondrial membrane permeability and inflammatory signaling in Müller cells via cGAS‐STING activation. SYK was necessary for cGAS–STING activation and increased cytokine expression in Müller cells. Müller glia‐specific SYK deletion reduced glial activation and attenuated inflammatory cytokine expression in the ...
Yerlikaya EI, Sunilkumar S, Subrahmanian SM, Toro AL, Yeager CT, Shaikh KA, Harhaj EW, Barber AJ, Dennis MD.   +8 more
europepmc   +2 more sources

Distribution of melanopsin positive neurons in pigmented and albino mice: evidence for melanopsin interneurons in the mouse retina. [PDF]

, 2014
Here we have studied the population of intrinsically photosensitive retinal ganglion cells (ipRGCs) in adult pigmented and albino mice. Our data show that although pigmented (C57Bl/6) and albino (Swiss) mice have a similar total number of ipRGCs, their ...
Agudo-Barriuso, M, Galindo-Romero, C, García-Ayuso, D, Jiménez-López, M, Ortín-Martínez, A, Valiente-Soriano, FJ, Vidal-Sanz, M, Villegas-Pérez, MP, Vugler, AA   +8 more
core