Results 141 to 150 of about 250,265 (247)

Short‐Chain Fatty Acids: Microbial Metabolites Driving Gut‐Eye Axis Signaling

Comprehensive Physiology, Volume 16, Issue 5, October 2026.
Short‐chain fatty acids generated by gut microbial fermentation link diet to ocular physiology via the gut–eye axis. Through systemic distribution, these metabolites regulate GPCR signaling, epigenetic pathways, inflammation, and angiogenesis, shaping retinal homeostasis and highlighting therapeutic potential in ocular vascular and inflammatory ...
Aleah J. Brokemond, Ronny Amamoo, Fapianey J. Alexandre, Sewedo B. Ajisegiri, Menaka C. Thounaojam, Pamela M. Martin, Ravirajsinh N. Jadeja   +6 more
wiley   +1 more source

EHA Guidelines on the management of children and adults with hemoglobin SC disease

HemaSphere, Volume 10, Issue 10, October 2026.
Abstract HbSC disease is the second most common type of sickle cell disease (SCD) in populations of African origin. Although it is often grouped together with other types of SCD, particularly sickle cell anemia (HbSS), it has unique pathophysiology and a different spectrum of laboratory and clinical features.
David C. Rees, Valentine Brousse, Mariane de Montalembert, Bart J. Biemond, Lucia De Franceschi, Eugene Oteng‐Ntim, Pagona Flevari, Valeria Pinto, John James, Elena Cela, Stefan Eber, Rachel Kesse‐Adu, Jennifer Knight‐Madden, France Pirenne, Aline Santin, Andreas Glenthøj   +15 more
wiley   +1 more source

Dissecting the angiogenic mechanism of pachychoroid polypoidal choroidal vasculopathy

iMeta, Volume 5, Issue 5, October 2026.
A prognosis‐oriented classification system was established to distinguish Pachy PCV from Non‐pachy PCV using a large multicenter dataset. Comparative plasma multi‐omics profiling of Pachy PCV, Non‐pachy PCV, and normal controls revealed unique upregulation of the fluid shear stress and atherosclerosis (FSS‐AS) and HIF‐1 signaling pathways in Pachy PCV.
Xinyu Zhao, Tiantian Cheng, Wenfei Zhang, Xingwang Gu, Qing Zhao, Yaning Chen, Lihui Meng, Jiaqi Zhang, Bintao Qiu, Lili Li, Shiyu Cheng, Zicheng Wang, Chuting Wang, Yuelin Wang, Zuyi Yang, Zhengming Shi, Ye Guo, Shengzhi Liu, Youxin Chen   +18 more
wiley   +1 more source

A new animal model of choriodal neovascularization

, 2005
ophthalmology, age-related macular degeneration, Bruch's membrane, retinal pigment epithelium, choroidal neovascularization, subretinal ...
Andersen, Mads V. Nis, Scherfig, E., Prause, J.U., Cour, Morten la, Tezel, Tongalp H., Wiencke, A.K., Kiilgaard, J.F.   +6 more
core   +1 more source

Multifunctional Hydrogels: Rational Design and Application in Regenerative Medicine

MedComm, Volume 7, Issue 10, October 2026.
Multifunctional hydrogels represent a paradigm shift in regenerative medicine, integrating rational material design with bioactive functionality to address complex tissue repair challenges. This review systematically examines the molecular engineering, structure–function relationships, and translational landscape of advanced hydrogel systems, spanning ...
Linyang Song, Epiphane K. Silli, Yazhen Xu, Huixia Lv, Ruoxian Song   +4 more
wiley   +1 more source

Small Leucine‐Rich Proteoglycans in Cancer: Three Decades of Discovery

Proteoglycan Research, Volume 4, Issue 4, October 2026.
ABSTRACT Small leucine‐rich proteoglycans (SLRPs) are a well‐known family of extracellular matrix (ECM) molecules. They consist of five classes with 18 different protein cores originally recognized as having a physically supportive component to the extracellular structure and tissue integrity.
Gabriel J. Pascal, Sadie Kim, Christopher Xie, Maria Danial, Iris Barone, Renato V. Iozzo   +5 more
wiley   +1 more source

DNA Origami Uptake in Y‐79 Retinoblastoma Cells Driven by Oligolysine Coating

Small Structures, Volume 7, Issue 10, October 2026.
We show that polymeric coating can enable DNA origami nanoparticle internalization into ocular retinoblastoma cells. Not only are the coated nanoparticles well‐tolerable to the cells, but they also remain mobile in the vitreous of a porcine ex vivo model.
Anna Klose, Zahra Gounani, Sergei Raik, Artturi Koivuniemi, Sonja Korhonen, Mika Reinisalo, Tatu Lajunen, Veikko Linko, Timo Laaksonen   +8 more
wiley   +1 more source

VEGFR2-dependent VEGFR3 expression leads to CXCL1/2 and CXCR2 induction in the development of retinal neovascularization. [PDF]

Angiogenesis
Yadavalli CS, Kumar R, Govatati S, Rao GN.   +3 more
europepmc   +1 more source

Zeb2 Controls Retinal Physiological and Pathological Angiogenesis by Regulating Astrocyte Proliferation and Differentiation

Cell Proliferation, Volume 59, Issue 10, October 2026.
During development, the oxygen‐sensitive transcription factor Zeb2 restrains astrocyte proliferation and maturation to ensure balanced retinal angiogenesis. In disease, it promotes the neurotoxic A1 astrocyte phenotype and inflammation, thereby promoting reparative revascularization over pathological neovascularization.
Jing Liu, Yanan Guo, Kangjian Xiang, Shuyi Wang, Dongchang Xiao, Mengqing Xiang   +5 more
wiley   +1 more source

Comparison between liraglutide and dulaglutide on the incidence or progression of eye and kidney complications

Journal of Diabetes Investigation, Volume 17, Issue 10, Page 1726-1734, October 2026.
We conducted the single‐center, retrospective cohort study to evaluate and compare the risk of diabetic eye and kidney complications between newly initiated once‐daily liraglutide (0.9 mg) and once‐weekly dulaglutide (0.75 mg) in 331 Japanese patients with type 2 diabetes.
Aki Katamine, Junko Oya, Yuichiro Kondo, Yukiko Hasegawa, Tomoko Nakagami   +4 more
wiley   +1 more source