Results 121 to 130 of about 625,953 (241)

Cytochrome P450 oxidase 2C inhibition adds to ω-3 long-chain polyunsaturated fatty acids protection against retinal and choroidal neovascularization

Arteriosclerosis, Thrombosis and Vascular Biology, 2016
Objective—Pathological ocular neovascularization is a major cause of blindness. Increased dietary intake of &ohgr;-3 long-chain polyunsaturated fatty acids (LCPUFA) reduces retinal neovascularization and choroidal neovascularization (CNV), but &ohgr;-3 ...
Yan Gong, Z. Fu, M. Edin, Chi-Hsiu Liu, Zhongxiao Wang, Zhuo Shao, Thomas W. Fredrick, Nicholas J. Saba, P. Morss, Samuel B Burnim, Steven S Meng, F. Lih, K. S. Lee, Elizabeth P. Moran, J. Sangiovanni, A. Hellström, B. Hammock, D. Zeldin, Lois E. H. Smith   +18 more
semanticscholar   +1 more source

Concurrent macular neovascularization in shallow irregular retinal pigment epithelium elevation phenotypes in age‐related macular degeneration and chronic central serous chorioretinopathy: A systematic review and meta‐analysis

Acta Ophthalmologica, EarlyView.
Abstract This systematic review and meta‐analysis synthesized the reported frequency of concurrent macular neovascularization (MNV) among selected eyes with author‐defined shallow irregular retinal pigment epithelium (RPE) elevations in age‐related macular degeneration (AMD) and chronic central serous chorioretinopathy (CSC).
Mehmet Cem Sabaner, Irem Gunes, Rodrigo Anguita, Elon H. C. van Dijk, Lorenzo Ferro Desideri, Lasse Jørgensen Cehofski, Prithvi Ramtohul, Yousif Subhi   +7 more
wiley   +1 more source

Regional growth kinetics of geographic atrophy in age‐related macular degeneration with and without fovea‐sparing

Acta Ophthalmologica, EarlyView.
Abstract Purpose Fovea‐sparing geographic atrophy (GA) patients retain near‐normal central vision. To better understand GA progression in relation to the fovea, we performed a semi‐automated image analysis of regional atrophy growth in a long‐term GA natural‐history cohort. Methods Prospective‐observational, single‐centre‐study (02/2013–07/2025) at the
Daniel R. Muth, Abinaya P. Venkataraman, Alberto Dominguez‐Vicent, Goran Petrovski, Pete A. Williams, Laurence Quérat, Filippo Locri, Sandrine A. Zweifel, Anders Kvanta   +8 more
wiley   +1 more source

The mechanism of CCN1-enhanced retinal neovascularization in oxygen-induced retinopathy through PI3K/Akt–VEGF signaling pathway

, 2015
Yu Di,1 Yiou Zhang,2 Hongwei Yang,1 Aiyuan Wang,1 Xiaolong Chen11Department of Ophthalmology, Shengjing Affiliated Hospital of China Medical University, Shenyang, People’s Republic of China; 2Graduate School, China Medical University, Shenyang ...
Yang H, Wang A, Zhang Y, Chen X, Di Y
core  

Neovascular glaucoma: pathophysiology, diagnosis, and contemporary management

Frontiers in Medicine
BackgroundNeovascular glaucoma (NVG) is a vision-threatening secondary glaucoma driven by pathologic neovascularization of the iris and anterior chamber angle and is most commonly secondary to ischemic retinal diseases.
Danyang Yu, Chaoxiong Cui, Guanghao Li, Zhenbao Wang   +3 more
doaj   +1 more source

CD93—An emerging vascular target in cancer therapy

British Journal of Pharmacology, EarlyView.
Abstract CD93 is a single‐pass transmembrane glycoprotein that belongs to the C‐type lectin domain group XIV family of proteins. Although it is known to be expressed in other cell types, namely, in some subsets of immune cells, CD93 is primarily expressed on endothelial cells, where it acts as a crucial regulator of angiogenesis.
Beatriz de Alves Pereira, Stefano Barbera, Roberta Lugano, Anna Dimberg   +3 more
wiley   +1 more source

Ref-1 redox activity modulates canonical Wnt signaling in endothelial cells

Redox Biology
Ischemic retinopathies, including proliferative diabetic retinopathy (PDR) and retinopathy of prematurity (ROP), are characterized by abnormal retinal neovascularization and can lead to blindness in children and adults.
Gabriella D. Hartman, Kamakshi Sishtla, Eyram K. Kpenu, Mahmut Mijit, Anbukkarasi Muniyandi, Ha-Neul Jo, Harald J. Junge, Aaron Shaw, Daniela Bischof, Sheng Liu, Jun Wan, Mark R. Kelley, Timothy W. Corson   +12 more
doaj   +1 more source

Zeb2 Controls Retinal Physiological and Pathological Angiogenesis by Regulating Astrocyte Proliferation and Differentiation

Cell Proliferation, EarlyView.
During development, the oxygen‐sensitive transcription factor Zeb2 restrains astrocyte proliferation and maturation to ensure balanced retinal angiogenesis. In disease, it promotes the neurotoxic A1 astrocyte phenotype and inflammation, thereby promoting reparative revascularization over pathological neovascularization.
Jing Liu, Yanan Guo, Kangjian Xiang, Shuyi Wang, Dongchang Xiao, Mengqing Xiang   +5 more
wiley   +1 more source

Elucidating the Role of Ref-1 in Retinal Neovascularization

IUIRetinal neovascularization in retinopathy of prematurity (ROP) and proliferative diabetic retinopathy (PDR) impairs vision. Current treatments of intravitreal (IVT) antivascular endothelial growth factor (VEGF) injections are accompanied by high ...
Hartman, Gabriella D.
core   +1 more source

Ocular Manifestations of Metabolic Syndrome: A Systemic Vascular Phenotype

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Context Metabolic syndrome (MetS) is defined by central obesity, insulin resistance, hypertension and dyslipidemia. MetS affects over one‐third of US adults. Beyond its cardiovascular burden, MetS has clinically relevant associations with ocular health and may contribute to a systemic vascular and neuro‐metabolic phenotype involving the retina,
Ron T. Varghese, Ansu A. John
wiley   +1 more source