Results 41 to 50 of about 625,953 (241)

A drug-tunable Flt23k gene therapy for controlled intervention in retinal neovascularization

Angiogenesis, 2020
Gene therapies that chronically suppress vascular endothelial growth factor (VEGF) represent a new approach for managing retinal vascular leakage and neovascularization.
Jinying Chen, Fan-Li Lin, J. Leung, Leilei Tu, Jiang-Hui Wang, Y. Chuang, Fan Li, Hsin-Hui Shen, G. Dusting, V. H. Wong, L. Lisowski, A. Hewitt, Bang V. Bui, Jingxiang Zhong, Guei-Sheung Liu   +14 more
semanticscholar   +1 more source

Sphingosine Kinase 2 Modulates Retinal Neovascularization in the Mouse Model of Oxygen-Induced Retinopathy. [PDF]

, 2018
Purpose Neovascularization is a major cause of blindness in various ocular diseases. Bioactive sphingosine 1-phosphate (S1P), synthesized by two sphingosine kinases (Sphk1, Sphk2), emerged as a key player in a multitude of cellular processes ...
Koch, Alexander, Devraj, Kavi, Lars-Olof Hattenbach, Vutukuri, Rajkumar, Yannick Schreiber, Huwiler, Andrea, Katrin Schröder, Kavi Devraj, Popp, Rüdiger, Alexander Koch, Martin Stumpf, Pfeilschifter, Josef, Nerea Ferreirós, Andrea Huwiler, Jeanette Eresch, Eresch, Jeanette, Hattenbach, Lars-Olof, Waltraud Pfeilschifter, Rüdiger Popp, Stumpf, Martin, Rajkumar Vutukuri, Ferreirós, Nerea, Pfeilschifter, Waltraud, Josef Pfeilschifter, Schreiber, Yannick, Schröder, Katrin   +25 more
core   +2 more sources

Concurrent management of myopic choroidal neovascularization and rhegmatogenous retinal detachment with intravitreal antivascular endothelial growth factor during primary retinal detachment repair

Indian Journal of Ophthalmology, 2018
We report concurrent management of rhegmatogenous retinal detachment and myopic choroidal neovascularization in the left eye of a 24-year-old female who presented with sudden dimness of vision due to retinal detachment and choroidal neovascularization ...
Kumar Saurabh, Rupak Roy, Nicey Roy Thomas, Maitreyi Chowdhury   +3 more
doaj   +1 more source

Targeting Neuroinflammation in Neovascular Retinal Diseases

Frontiers in Pharmacology, 2020
Retinal blood vessels provide the necessary energy, nutrients and oxygen in order to support visual function and remove harmful particles from blood, thus acting to protect neuronal cells.
Tianxi Wang, Demetrios I. Tsirukis, Ye Sun   +2 more
doaj   +1 more source

Bim expression in endothelial cells and pericytes is essential for regression of the fetal ocular vasculature. [PDF]

PLoS ONE, 2017
Apoptosis plays a central role in developmental and pathological angiogenesis and vessel regression. Bim is a pro-apoptotic Bcl-2 family member that plays a prominent role in both developmental and pathological ocular vessel regression, and ...
Shoujian Wang, Ismail S Zaitoun, Ryan P Johnson, Nasim Jamali, Zafer Gurel, Catherine M Wintheiser, Andreas Strasser, Volkhard Lindner, Nader Sheibani, Christine M Sorenson   +9 more
doaj   +1 more source

Mechanism of piR-1245/PIWI-like protein-2 regulating Janus kinase-2/signal transducer and activator of transcription-3/vascular endothelial growth factor signaling pathway in retinal neovascularization

Neural Regeneration Research, 2023
Inhibiting retinal neovascularization is the optimal strategy for the treatment of retina-related diseases, but there is currently no effective treatment for retinal neovascularization.
Yong Yu, Li-Kun Xia, Yu Di, Qing-Zhu Nie, Xiao-Long Chen   +4 more
doaj   +1 more source

Vascular cell-adhesion molecule 1 (VCAM-1) regulates JunB-mediated IL-8/CXCL1 expression and pathological neovascularization

Communications Biology, 2023
Vascular adhesion molecules play an important role in various immunological disorders, particularly in cancers. However, little is known regarding the role of these adhesion molecules in proliferative retinopathies.
Geetika Kaur, Deepti Sharma, Shivantika Bisen, Chandra Sekhar Mukhopadhyay, Katherine Gurdziel, Nikhlesh K. Singh   +5 more
doaj   +1 more source

Inflammatory retinal and choroidal neovascularization in a case of post-fever immune retinitis

Indian Journal of Ophthalmology. Case Reports, 2021
The development of retinal and choroidal neovascularization in posterior uveitis is attributed to the angio-inflammatory drive with/without ruptures in the retinal pigment epithelium-Bruch's membrane complex.
Pratik Shenoy, Gaurav Mohan Kohli, Priyavrat Bhatia, Alok Sen   +3 more
doaj   +1 more source

Therapeutic effect against retinal neovascularization in a mouse model of oxygen-induced retinopathy: bone marrow-derived mesenchymal stem cells versus Conbercept

BMC Ophthalmology, 2020
Background To study the therapeutic effect of bone marrow-derived mesenchymal stem cells (BMSC) against retinal neovascularization and to compare with anti-vascular endothelial growth factor (VEGF) therapy.
Wei Xu, Weijing Cheng, Xiaoyuan Cui, Guoxing Xu   +3 more
doaj   +1 more source

Identifying circRNA-associated-ceRNA networks in retinal neovascularization in mice

International Journal of Medical Sciences, 2019
Retinal neovascularization is a complication which caused human vision loss severely. It has been shown that circular RNAs (circRNAs) play essential roles in gene regulation.
Manjing Cao, Lu-Si Zhang, Jiang-Hui Wang, Huilan Zeng, Yingqian Peng, Jingling Zou, Jingming Shi, Li-Wei Zhang, Yun Li, S. Yoshida, Luo-sheng Tang, Ye-Di Zhou   +11 more
semanticscholar   +1 more source