Results 31 to 40 of about 625,953 (241)

Downregulation of PIK3IP1 in retinal microglia promotes retinal pathological neovascularization via PI3K-AKT pathway activation

Scientific Reports, 2023
Retinal pathological neovascularization involves endothelial cells, pericytes, photoreceptor cells, ganglion cells, and glial cells, whose roles remain unclear.
Lushu Chen, Yuan Cao, Yaming Shen, Huan Li, Rong Ye, Jin Yao   +5 more
doaj   +1 more source

An allosteric peptide inhibitor of HIF-1α regulates hypoxia-induced retinal neovascularization

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance Retinal ischemia causes hypoxia-induced neovascularization that stimulates production of proangiogenic cytokines such as VEGF by the hypoxia-inducible transcription factors HIF-1 and HIF-2.
Ayumi Usui-Ouchi, E. Aguilar, Salome Murinello, M. Prins, M. Gantner, P. Wright, R. Berlow, M. Friedlander   +7 more
semanticscholar   +1 more source

Inhibiting NF-κB Signaling Activation Reduces Retinal Neovascularization by Promoting a Polarization Shift in Macrophages

Investigative Ophthalmology and Visual Science, 2020
Purpose Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling is involved in regulating tumor angiogenesis and metastasis; however, the exact mechanism of action in retinal neovascularization (RNV) remains unclear.
Ailing Sui, Xiuping Chen, A. Demetriades, Ji-Kui Shen, Yujuan Cai, Yi-Yun Yao, Yi-Xuan Yao, Yanji Zhu, Xi Shen, B. Xie   +9 more
semanticscholar   +1 more source

Fluorescein angiography compared to three-dimensional measurements by the retinal thickness analyzer in classic choroidal neovascularization [PDF]

, 2007
Purpose: To compare and correlate imaging of classic subfoveal choroidal neovascularization (CNV) with noninvasive 3-dimensional imaging by the retinal thickness analyzer (RTA) to conventional fluorescein angiography (FA).
Strauss, R. W., Rombold, F., Neubauer, A. S., Kampik, Anselm   +3 more
core   +1 more source

PPARα-Dependent Effects of Palmitoylethanolamide Against Retinal Neovascularization and Fibrosis

Investigative Ophthalmology and Visual Science, 2020
Purpose Pathological neovascularization and fibrosis are common pathological changes of many retinal diseases, such as proliferative retinopathy (PR) and age-related macular degeneration (AMD).
Sihao Ye, Qian Chen, Nan Jiang, Xu Liang, Jing-Ming Li, R. Zong, Caihong Huang, Y. Qiu, Jian-Xing Ma, Zuguo Liu   +9 more
semanticscholar   +1 more source

VEGF(164)-mediated inflammation is required for pathological, but not physiological, ischemia-induced retinal neovascularization [PDF]

, 2003
Hypoxia-induced VEGF governs both physiological retinal vascular development and pathological retinal neovascularization. In the current paper, the mechanisms of physiological and pathological neovascularization are compared and contrasted.
Ogura, Y, Ng, Yin-Shan, Adamis, Anthony P., Kenji Yamashiro, Usui, Tomohiko, Hida, Tetsuo, Yuichi Kaji, Evangelos S. Gragoudas, Yin-Shan Ng, Shiro Amano, Amano, Shiro, Miller, Joan W., Yuichiro Ogura, Patricia A. D'Amore, Ambati, Jayakrishna, Shima, David T., Gragoudas, Evangelos S., Miller, JW, D'Amore, PA, Yoshihisa Oguchi, Hida, T, Ishida, S, Gragoudas, ES, Usui, T, Tetsuo Hida, Ogura, Yuichiro, Tomohiko Usui, Jayakrishna Ambati, Shima, DT, Joan W. Miller, Kaji, Yuichi, D\u27Amore, Patricia A., Ambati, J, Adamis, AP, Anthony P. Adamis, Kaji, Y, Yamashiro, K, Amano, S, Oguchi, Y, Oguchi, Yoshihisa, David T. Shima, Yamashiro, Kenji, Susumu Ishida, Ishida, Susumu, Ng, YS   +44 more
core   +1 more source

Natriuretic Peptides Attenuate Retinal Pathological Neovascularization Via Cyclic GMP Signaling in Pericytes and Astrocytes. [PDF]

, 2020
OBJECTIVE In proliferative retinopathies, complications derived from neovascularization cause blindness. During early disease, pericyte's apoptosis contributes to endothelial dysfunction and leakage.
Kämmerer, Ulrike, Spes, Katarina Špiranec, Hupp, Sabrina, Kuhn, Michaela, Koch, Franziska, Heinze, Katrin G, Braunger, Barbara M, Völker, Katharina, Werner, Franziska, Krebes, Lisa   +9 more
core   +1 more source

MFGE8 does not influence chorio-retinal homeostasis or choroidal neovascularization in vivo [PDF]

, 2012
Purpose: Milk fat globule-epidermal growth factor-factor VIII (MFGE8) is necessary for diurnal outer segment phagocytosis and promotes VEGF-dependent neovascularization.
David-Alexandre Tregouet (4350982), Florian Sennlaub (64439), Xavier Guillonneau, William Raoul (64427), Sophie Krumeich (177422), Sophie Krumeich, Raoul William, Théry Clotilde, Calippe Bertrand, Salomon-Yves Cohen, Poupel Lucie, Camelo, Serge, Xavier Guillonneau (64430), Bertrand Calippe, Behar-Cohen Francine, Tregouet, David-Alexandre, Baatz, Holger, Bertrand Calippe (177425), Florian Sennlaub, Lucie Poupel, Francine Behar-Cohen, Théry, Clotilde, Sophie Lavalette (64428), Serge Camelo (177419), Calippe, Bertrand, Cohen Salomon-Yves, Lavalette Sophie, Behar-Cohen, Francine, Clotilde Théry (177438), Lavalette, Sophie, Tregouet David-Alexandre, Christophe Combadière, Combadière Christophe, Raoul, William, William Raoul, Sennlaub Florian, Salomon-Yves Cohen (177429), Baatz Holger, Guillonneau, Xavier, Nicole Keller, Keller, Nicole, Guillonneau Xavier, Camelo Serge, Nicole Keller (64429), Keller Nicole, Cohen, Salomon-Yves, David-Alexandre Tregouet, Serge Camelo, Sophie Lavalette, Holger Baatz (177431), Krumeich Sophie, Christophe Combadière (177434), Sennlaub, Florian, Combadière, Christophe, Poupel, Lucie, Krumeich, Sophie, Lucie Poupel (177410), Holger Baatz, Clotilde Théry, Francine Behar-Cohen (64434), Behar-Cohen, F., Krumeich, S., Camelo, S., Combadière, C., Guillonneau, X., Baatz, H., Sennlaub, F., Calippe, B., Poupel, L., Théry, C., Keller, N., Lavalette, S., Cohen, S.Y., Tregouet, D.A., Raoul, W.   +74 more
core   +1 more source

Long-term visual and microperimetry outcomes following autologous retinal pigment epithelium choroid graft for neovascular age-related macular degeneration [PDF]

, 2009
To describe the 2- to 4-year visual and microperimetry outcomes of autologous retinal pigment epithelium (RPE)-choroid graft in patients with neovascular age-related macular degeneration (AMD).In this retrospective cohort study, 12 patients with ...
Coffey, PJ, Uppal, GS, Rubin, GS, Chen, FK, Tufail, A, Maclaren, Robert, Franzco, FKC, Aylward, GW, Da Cruz, L, MacLaren, RE   +9 more
core   +1 more source

Vitreoretinal Interface Slab in OCT Angiography for Detecting Diabetic Retinal Neovascularization.

Ophthalmology Retina, 2020
PURPOSE To compare neovascularization identified in proliferative diabetic retinopathy (PDR) eyes by widefield swept-source (SS) OCT angiography (OCTA) using vitreoretinal interface (VRI) slab images, composed by automated and manual segmentation, with ...
Takao Hirano, Ken Hoshiyama, Kazutaka Hirabayashi, Masumi Wakabayashi, Yuichi Toriyama, Motoharu Tokimitsu, T. Murata   +6 more
semanticscholar   +1 more source