Results 21 to 30 of about 625,953 (241)

Peripapillary retinal neovascularization and vitreous hemorrhage secondary to peripapillary pachychoroid syndrome [PDF]

American Journal of Ophthalmology Case Reports
Purpose: To report a case of peripapillary pachychoroid syndrome (PPS) complicated with peripapillary retinal neovascularization causing vitreous hemorrhage.
Imène Zhioua Braham, Mejdi Boukari, Rim Maalej, Ilhem Mili, Raja Zhioua   +4 more
doaj   +2 more sources

VEGF-targeting drugs for the treatment of retinal neovascularization in diabetic retinopathy

Annals medicus, 2022
Diabetic retinopathy (DR) is the most common microangiopathic complication of diabetes mellitus, representing a major cause of visual impairment in developed countries.
A. Arrigo, E. Aragona, F. Bandello
semanticscholar   +1 more source

PAI-1 is a vascular cell–specific HIF-2–dependent angiogenic factor that promotes retinal neovascularization in diabetic patients

Science Advances, 2022
For patients with proliferative diabetic retinopathy (PDR) who do not respond adequately to pan-retinal laser photocoagulation (PRP) or anti–vascular endothelial growth factor (VEGF) therapies, we hypothesized that vascular cells within neovascular ...
Yao-Wu Qin, Jing Zhang, Savalan Babapoor-Farrokhran, B. Applewhite, M. Deshpande, Haley Megarity, Miguel Flores-Bellver, Silvia Aparicio-Domingo, Tao Ma, Yuan Rui, S. Tzeng, J. Green, M. V. Canto-Soler, S. Montaner, Akrit Sodhi   +14 more
semanticscholar   +1 more source

HIF-1α and HIF-2α redundantly promote retinal neovascularization in patients with ischemic retinal disease.

Journal of Clinical Investigation, 2021
Therapies targeting VEGF have proven only modestly effective for the treatment of proliferative sickle cell retinopathy (PSR), the leading cause of blindness in patients with sickle cell disease.
Jing Zhang, Yao-Wu Qin, Mireya Martínez, Miguel Flores-Bellver, Murilo Rodrigues, Aumreetam Dinabandhu, Xuan Cao, M. Deshpande, Yu Qin, Silvia Aparicio-Domingo, Yuan Rui, S. Tzeng, Shaima Salman, Jinxia Yuan, A. Scott, J. Green, M. V. Canto-Soler, G. Semenza, S. Montaner, Akrit Sodhi   +19 more
semanticscholar   +1 more source

TAK1 blockade as a therapy for retinal neovascularization.

Pharmacological Research, 2022
Retinal neovascularization, or pathological angiogenesis in the retina, is a leading cause of blindness in developed countries. Transforming growth factor-β-activated kinase 1 (TAK1) is a mitogen-activated protein kinase kinase kinase (MAPKKK) activated ...
Jiang-Hui Wang, Fan-Li Lin, Jinying Chen, Linxin Zhu, Y. Chuang, Leilei Tu, Chenkai Ma, Damien L. Ling, A. Hewitt, Ching-Li Tseng, Manisha H Shah, Bang V. Bui, P. van Wijngaarden, G. Dusting, Peng-Yuan Wang, Guei-Sheung Liu   +15 more
semanticscholar   +1 more source

Intravitreal Aflibercept as a Rescue Therapy for Retinal Neovascularization and Macular Edema due to Eales Disease

Case Reports in Ophthalmological Medicine, 2021
We report the rescue effect of intravitreal aflibercept injections on retinal neovascularization and macular edema due to Eales disease. Case 1 was a 36-year-old female. Intravitreal aflibercept was administered as rescue therapy after persistent retinal
Ning-Yi Hsia, Chun-Ju Lin, Chun-Ting Lai, Henry Bair, Cheng-Hsien Chang, Jane-Ming Lin, Yi-Yu Tsai   +6 more
doaj   +1 more source

The progress of prophylactic treatment in retinopathy of prematurity [PDF]

International Journal of Ophthalmology, 2018
Retinopathy of prematurity (ROP) is a retinal vascular disorder frequently found in premature infants. Different therapeutic strategies have been developed to treat ROP.
Hong-Bing Zhang, Xiao-Dong Wang, Kun Xu, Xiao-Gang Li   +3 more
doaj   +1 more source

Peripheral retinal neovascularization in a patient with obstructive sleep apnea

American Journal of Ophthalmology Case Reports, 2022
Purpose: To describe a case of peripheral retinal neovascularization and its possible etiological connection to comorbid obstructive sleep apnea. Observations: In this case report we describe a diabetic patient with obstructive sleep apnea who presented ...
Ravin Sajnani, Elena Karapetian, Abhinav Golla, Irena Tsui, David Sarraf   +4 more
doaj   +1 more source

An Endostatin-lentivirus (ES-LV)-EPC gene therapy agent for suppression of neovascularization in oxygen-induced retinopathy rat model

BMC Molecular and Cell Biology, 2020
Background Transplantation of gene transfected endothelial progenitor cells (EPCs) has provided novel methods for tumor neovascularization therapy but not for ocular disease therapy.
Jing Ai, Jian Ma, Zhi-Qing Chen, Jun-Hui Sun, Ke Yao   +4 more
doaj   +1 more source

YY1 lactylation in microglia promotes angiogenesis through transcription activation-mediated upregulation of FGF2

Genome Biology, 2023
Background Ocular neovascularization is a leading cause of blindness. Retinal microglia have been implicated in hypoxia-induced angiogenesis and vasculopathy, but the underlying mechanisms are not entirely clear.
Xiaotang Wang, Wei Fan, Na Li, Yan Ma, Mudi Yao, Guoqing Wang, Siyuan He, Wanqian Li, Jun Tan, Qi Lu, Shengping Hou   +10 more
doaj   +1 more source