Results 71 to 80 of about 371,429 (272)
Animal models of choroidal and retinal neovascularization [PDF]
Progress in Retinal and Eye Research, 2010 There have been numerous types of animal models of choroidal neovascularization (CNV) and retinal neovascularization (RNV). Understanding the pathobiology of CNV and RNV is important when evaluating and utilizing these models. Both CNV and RNV are dynamic processes. A break or defect in Bruchs' membrane is necessary for CNV to develop.
Shin J. Kang +2 more
openaire +3 more sources
BMEMat, EarlyView.Efficient drug delivery to the posterior segment of the eye has long been a challenging issue due to the complex ocular barriers. The review focuses on the promise held by nanoplatforms for barrier penetration and the key mechanisms involved, also highlighting their advantages in achieving efficient drug delivery and superior treatment of PSEDs ...
Yifan Shen +7 more
wiley +1 more source
BMC Complementary and Alternative Medicine, 2016 BackgroundRetinal neovascularization, which is the pathological growth of new blood vessels, is associated with retinopathy of prematurity, neovascular age-related macular degeneration, diabetic retinopathy and retinal vein occlusion.
Y. Lee +6 more
semanticscholar +1 more source
The Journal of Clinical Pharmacology, EarlyView.Abstract Compared to traditional small molecule drugs, monoclonal antibodies (mAbs) often display more complex pharmacokinetic (PK) and pharmacodynamic (PD) properties that may be impacted by disease‐specific factors. For mAbs in non‐oncology indications, where the same drug might be used for conditions involving different organ systems and/or having ...
Sherouk M. Tawfik, Fei Tang
wiley +1 more source
Dietary Compound Chrysin Inhibits Retinal Neovascularization with Abnormal Capillaries in db/db Mice
Nutrients, 2016 Diabetic retinopathy (DR) develops in a significant proportion of patients with chronic diabetes, characterized by retinal macular edema and abnormal retinal vessel outgrowth leading to vision loss.
Min-Kyung Kang +7 more
semanticscholar +1 more source
Laser &Photonics Reviews, EarlyView.This review explores deconvolution techniques in optical coherence tomography (OCT), addressing resolution degradation from point‐spread functions (PSF). It reviews foundational principles (e.g., Richardson‐Lucy deconvolution) to advanced AI‐driven methods, emphasizing clinical translation and interdisciplinary collaboration. Real‐world implementations
Syeda Aimen Abbasi +6 more
wiley +1 more source
Macromolecular Materials and Engineering, EarlyView.In this research, the amniotic membrane is sought to be enhanced biologically by treating it with primary cultured corneal cells. The findings indicate that amniotic membranes conditioned with limbal stem cells serve as an effective wound dressing that mimics corneal tissue, offering better cell adhesion, and healing properties, paving the way for ...
Zeinab Nokhbedehghan +10 more
wiley +1 more source
Mild endoplasmic reticulum stress promotes retinal neovascularization via induction of BiP/GRP78. [PDF]
PLoS ONE, 2013 Endoplasmic reticulum (ER) stress occurs as a result of accumulation of unfolded or misfolded proteins in the ER and is involved in the mechanisms of various diseases, such as cancer and neurodegeneration. The goal of the present study was to clarify the
Shinsuke Nakamura +6 more
doaj +1 more source
Current Advances in the Combination of Fatty Acids and Resveratrol to Fight Ocular Diseases
Molecular Nutrition &Food Research, EarlyView.Graphical abstract illustrating the effects of Resvega administration on choroidal neovascularization and resveratrol metabolism in the retina. The diagram illustrates that oral administration of Resvega leads to a decrease in choroidal neovascularization.
Dominique Delmas +3 more
wiley +1 more source
Molecular Nutrition &Food Research, EarlyView.(Poly)phenols constitute a source of natural therapeutic molecules capable of targeting angiogenesis in different scenarios. This review summarizes the current evidence of the role of (poly)phenols in modulating angiogenesis. The reader can find a compilation of preclinical and human investigations describing pro‐ and anti‐angiogenic effects of these ...
María Ángeles Ávila‐Gálvez +5 more
wiley +1 more source