Results 91 to 100 of about 41,612 (247)

VEGF164-mediated Inflammation Is Required for Pathological, but Not Physiological, Ischemia-induced Retinal Neovascularization [PDF]

, 2018
Hypoxia-induced VEGF governs both physiological retinal vascular development and pathological retinal neovascularization. In the current paper, the mechanisms of physiological and pathological neovascularization are compared and contrasted.
Miller, Joan, Ng, Yin-Shan, Gragoudas, Evangelos, Ogura, Yuichiro, Usui, Tomohiko, Hida, Tetsuo, Kaji, Yuichi, Amano, Shiro, Ambati, Jayakrishna, Shima, David T., Oguchi, Yoshihisa, Yamashiro, Kenji, D'Amore, Patricia, Ishida, Susumu, Adamis, Anthony   +14 more
core   +1 more source

Aqueous Humour Cytokines as Predictors of Axial Elongation in High Myopia: A 2‐Year Longitudinal Cohort Study

Clinical &Experimental Ophthalmology, EarlyView.
ABSTRACT Background To investigate the predictive value of aqueous humour cytokines for axial elongation. Methods This was a prospective longitudinal observational study. 72 high myopia patients (72 eyes) who received implantable collamer lens (ICL) implantation surgery with at least 2 years of follow‐up were included.
Lihui Meng, Yan Luo, Zhengming Shi, Youxin Chen, Zhikun Yang   +4 more
wiley   +1 more source

Expanding horizons of intravitreal anti-vascular endothelial growth factor therapy in retinal diseases

Indian Journal of Ophthalmology
Vascular endothelial growth factor (VEGF) plays a central role in the pathogenesis of retinal and choroidal neovascularization, as well as macular edema (ME), in retinal disorders such as diabetic retinopathy, retinal vein occlusion (RVO), and age ...
Shalini Singh, Urvashi Kala, Arjun Bamel, Manisha Agarwal   +3 more
doaj   +1 more source

Long-term retinal PEDF overexpression prevents neovascularization in a murine adult model of retinopathy.

PLoS ONE, 2012
Neovascularization associated with diabetic retinopathy (DR) and other ocular disorders is a leading cause of visual impairment and adult-onset blindness. Currently available treatments are merely palliative and offer temporary solutions. Here, we tested
Virginia Haurigot, Pilar Villacampa, Albert Ribera, Assumpcio Bosch, David Ramos, Jesus Ruberte, Fatima Bosch   +6 more
doaj   +1 more source

The mechanism of CCN1-enhanced retinal neovascularization in oxygen-induced retinopathy through PI3K/Akt–VEGF signaling pathway

, 2015
Yu Di,1 Yiou Zhang,2 Hongwei Yang,1 Aiyuan Wang,1 Xiaolong Chen11Department of Ophthalmology, Shengjing Affiliated Hospital of China Medical University, Shenyang, People’s Republic of China; 2Graduate School, China Medical University, Shenyang ...
Yang H, Wang A, Zhang Y, Chen X, Di Y
core  

Stage‐Associated Microglial Subpopulations and Dynamics in Vascular Pathogenesis of Oxygen‐Induced Retinopathy

Cell Proliferation, EarlyView.
In the oxygen‐induced retinopathy (OIR) mouse model, two distinct microglial subpopulations play opposing roles: highly glycolytic microglia (HGM) promote neovascular formation via Pkm2, while Mrc1/CD206‐positive phagocytosis‐associated microglia (PAM) facilitate its regression.
Yuan Ma, Ziye Chen, Baoyi Liu, Wen Ding, Runping Duan, Kangjie Kong, Zhuojun Xu, Jizhu Li, Jiali Ru, Dianlei Guo, Xiaoyue Wei, Yaping Liu, Zhuangling Lin, Yang Meng, Yuan Liu, Lan Jiang, Zitong Chen, Rebiya Tuxun, Chinling Tsai, Chunqiao Liu, Tao Li   +20 more
wiley   +1 more source

A Challenging Approach: Iris Neovascularization and Vitreous Hemorrhage 40 Years after Treatment of Retinal Giant Tear Detachment

International Medical Case Reports Journal
Ingrid Kreissig,1 Stefan Mennel2 1Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University Heidelberg, Mannheim, Germany; 2Department of Ophthalmology, Phillips-University Marburg, Marburg, GermanyCorrespondence: Ingrid ...
Kreissig I, Mennel S
doaj  

Zeb2 Controls Retinal Physiological and Pathological Angiogenesis by Regulating Astrocyte Proliferation and Differentiation

Cell Proliferation, EarlyView.
During development, the oxygen‐sensitive transcription factor Zeb2 restrains astrocyte proliferation and maturation to ensure balanced retinal angiogenesis. In disease, it promotes the neurotoxic A1 astrocyte phenotype and inflammation, thereby promoting reparative revascularization over pathological neovascularization.
Jing Liu, Yanan Guo, Kangjian Xiang, Shuyi Wang, Dongchang Xiao, Mengqing Xiang   +5 more
wiley   +1 more source

Anti-angiogenic effects of a mutant endostatin: a new prospect for treating retinal and choroidal neovascularization.

, 2014
Pathological fundus angiogenesis is a major cause of vision loss in retina diseases. Endostatin, a C-terminal fragment of collagen XVIII, is an endogenous anti-angiogenic protein.
Shanshan Li, Bin Wang, Lvzhen Huang (128928), Min Zhao, Yun Qi, Li, Xiaoxin, Chunfang Zhang (7405), Qi, Yun, Zhao, Min, Xiaoxin Li, Bai, Yujing, Chunfang Zhang, Huang, Lvzhen, Lvzhen Huang, Wang, Bin, Shanshan Li (114847), Yujing Bai (170144), Yujing Bai, Min Zhao (66793), Xiaoxin Li (128947), Zhang, Chunfang, Yun Qi (560401), Bin Wang (30851), Li, Shanshan   +23 more
core   +1 more source

Risk of Age‐Related Ocular Diseases in Non‐Diabetic Adults With Obesity Using Glucagon‐Like Peptide 1 Receptor Agonists

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims To assess whether glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) are associated with a lower incidence of age‐related ocular diseases in non‐diabetic older adults with overweight or obesity. Materials and Methods We conducted a retrospective, propensity score–matched cohort study using the TriNetX global research network.
Kuo‐En Chen, Po‐Chun Wang, Hui‐An Lin, Sheng‐Feng Lin   +3 more
wiley   +1 more source