Results 81 to 90 of about 250,265 (247)

Genome‐wide association and interaction analysis for proliferative retinopathy in adults with type 2 diabetes born during famine: The DOLCE study in Ukraine

Acta Ophthalmologica, EarlyView.
Abstract Purpose Proliferative diabetic retinopathy (PDR) is one of the leading causes of blindness in working‐age adults. We have previously shown that the risk of PDR is significantly elevated in individuals with intrauterine exposure to famine. However, the genetic mechanisms mediating this association remain unknown.
Olena Fedotkina, Most Champa Begum, Xuan Tung Trinh, Turkuler Özgumus, Mikael Åkerlund, Peter Nilsson, Leticia Maria Spindola, Valeriya Lyssenko   +7 more
wiley   +1 more source

VEGF164-mediated Inflammation Is Required for Pathological, but Not Physiological, Ischemia-induced Retinal Neovascularization [PDF]

, 2003
Hypoxia-induced VEGF governs both physiological retinal vascular development and pathological retinal neovascularization. In the current paper, the mechanisms of physiological and pathological neovascularization are compared and contrasted.
Ng, Yin-Shan, Adamis, Anthony P., Kenji Yamashiro, Usui, Tomohiko, Hida, Tetsuo, Yuichi Kaji, Evangelos S. Gragoudas, Yin-Shan Ng, Shiro Amano, Amano, Shiro, Miller, Joan W., Yuichiro Ogura, Patricia A. D'Amore, Ambati, Jayakrishna, Shima, David T., Gragoudas, Evangelos S., Yoshihisa Oguchi, Tetsuo Hida, Ogura, Yuichiro, Tomohiko Usui, Jayakrishna Ambati, Joan W. Miller, Kaji, Yuichi, D\u27Amore, Patricia A., Anthony P. Adamis, Oguchi, Yoshihisa, David T. Shima, Yamashiro, Kenji, Susumu Ishida, Ishida, Susumu   +29 more
core   +1 more source

Childhood ocular safety after postnatal exposure to topical dexamethasone during retinopathy of prematurity screening

Acta Ophthalmologica, EarlyView.
Abstract Purpose Dexamethasone eye drops are being introduced off‐label to prevent progression of severe retinopathy of prematurity (ROP). We evaluated ophthalmologic outcomes in early childhood after postnatal topical dexamethasone exposure in pre‐term infants at a standardized follow‐up examination.
Mariya Petrishka‐Lozenska, Anders K. Nilsson, Ann Hellström, Pia Lundgren   +3 more
wiley   +1 more source

Receptor-Interacting Protein Kinase-3 Expression Impacts Ocular Vascular Development and Pathological Neovascularization

Cells
Functional cell death pathways are essential for normal ocular vascular development and tissue homeostasis. As our understanding of necrosis-based cell death pathways has expanded, the inclusion of regulated forms, including necroptosis, ferroptosis, and
Yong-Seok Song, Shoujian Wang, SunYoung Park, Barbara Hanna, Kelsey J. Johnson, Soesiawati R. Darjatmoko, Mohammad Ali Saghiri, Ali Mohammad Saghiri, Bo Liu, Christine M. Sorenson, Nader Sheibani   +10 more
doaj   +1 more source

Macular telangiectasia type 2 genetic risk variants associated with clinical characteristics in the Slovenian cohort

Acta Ophthalmologica, EarlyView.
Abstract Purpose Early diagnosis of macular telangiectasia type 2 (MacTel) remains challenging, and the contribution of genetic variation to its clinical heterogeneity is unclear. This study investigated associations between MacTel risk variants and clinical characteristics in a Slovenian cohort.
Ajda Kunčič, Nataša Debeljak, Petra Hudler, Janez Smerkolj, Mojca Urbančič   +4 more
wiley   +1 more source

VEGF164-mediated Inflammation Is Required for Pathological, but Not Physiological, Ischemia-induced Retinal Neovascularization [PDF]

, 2018
Hypoxia-induced VEGF governs both physiological retinal vascular development and pathological retinal neovascularization. In the current paper, the mechanisms of physiological and pathological neovascularization are compared and contrasted.
Miller, Joan, Ng, Yin-Shan, Gragoudas, Evangelos, Ogura, Yuichiro, Usui, Tomohiko, Hida, Tetsuo, Kaji, Yuichi, Amano, Shiro, Ambati, Jayakrishna, Shima, David T., Oguchi, Yoshihisa, Yamashiro, Kenji, D'Amore, Patricia, Ishida, Susumu, Adamis, Anthony   +14 more
core   +1 more source

Explainable deep learning self‐supervised vision transformer for fundus‐based myopia classification

Acta Ophthalmologica, EarlyView.
Abstract Purpose To develop and validate a self‐supervised vision transformer (ViT) for automated three‐class classification of Normal, High Myopia (HM), and Pathologic Myopia (PM) from colour fundus photographs, with anatomically faithful interpretability. Methods A DINOv2 self‐supervised ViT was fine‐tuned using a two‐stage transfer‐learning protocol
Eirini Maliagkani, Christos Tsoutsas, Nikolaos Papageorgiou, Ioannis D. Apostolopoulos, Nikolaos Papandrianos, Ilias Georgalas, Elpiniki Papageorgiou   +6 more
wiley   +1 more source

Clinical outcomes of the PAUL® glaucoma implant for secondary glaucoma

Acta Ophthalmologica, EarlyView.
Abstract Purpose Secondary glaucoma encompasses a broad spectrum of disease entities arising from diverse ocular pathologies and is often refractory to conventional treatment. Glaucoma drainage devices (GDDs) have therefore become an important surgical option.
Carolin Deubel, Benjamin Aretz, Wolfgang Walz, Michael Petrak, Frank G. Holz, Raffael Liegl, Karl Mercieca, Constance Liegl   +7 more
wiley   +1 more source

MYDGF promotes pathological and physiological retinal angiogenesis via the Gαi1/3-Gab1-Akt-mTOR signaling

Nature Communications
Retinal neovascularization (RNV) is a potential vision-threatening process characterized by the abnormal growth of retinal vessels. Despite its clinical prevalence, the precise mechanisms governing RNV initiation and progression remain incompletely ...
Ke-ran Li, Ping-ping Fu, Wen Bai, Chao-wen Bai, Yitian Yang, Le Liu, Jin-long Chai, Yujia Yao, Dan Huang, Zhi-qing Zhang, Qin Jiang, Zhou-rui Ma, Yu Feng, Jin Yao, Cong Cao   +14 more
doaj   +1 more source

Neurofibromin Deficiency Induces Endothelial Cell Proliferation and Retinal Neovascularization

, 2018
Purpose: Neurofibromatosis type 1 (NF1) is the result of inherited mutations in the NF1 tumor suppressor gene, which encodes the protein neurofibromin.
Stephen B. Haigh, Brian K. Stansfield, Weintraub, Neal L., Chintan Patel, Hudson, Farlyn Z., David A. Ingram, Ingram, David A., Rojas, Modesto, Fulton, David J., Stansfield, Brian K., Rebekah Tritz, Hanfang Zhang, Xu, Zhimin, Caldwell, Ruth B., Patel, Chintan, Modesto Rojas, Tritz, Rebekah, Neal L. Weintraub, Zhang, Hanfang, Bordán, Zsuzsanna, Zsuzsanna Bordán, Farlyn Z. Hudson, David J. Fulton, Zhimin Xu, Haigh, Stephen B., Ruth B. Caldwell   +25 more
core   +1 more source