Results 11 to 20 of about 138,851 (338)
eLife, 2017 Here we report multiple lines of evidence for a comprehensive model of energy metabolism in the vertebrate eye. Metabolic flux, locations of key enzymes, and our finding that glucose enters mouse and zebrafish retinas mostly through photoreceptors ...
Mark A Kanow +16 more
doaj +2 more sources
Oxidative Stress-Involved Mitophagy of Retinal Pigment Epithelium and Retinal Degenerative Diseases
Cellular and molecular neurobiology, 2023 The retinal pigment epithelium (RPE) is a highly specialized and polarized epithelial cell layer that plays an important role in sustaining the structural and functional integrity of photoreceptors.
Siqi Zhang +4 more
semanticscholar +1 more source
Neural Regeneration Research, 2023 Age-related macular degeneration is a primary cause of blindness in the older adult population. Past decades of research in the pathophysiology of the disease have resulted in breakthroughs in the form of anti-vascular endothelial growth factor therapies
M. Maurya +6 more
semanticscholar +1 more source
Involvement of FSP1-CoQ10-NADH and GSH-GPx-4 pathways in retinal pigment epithelium ferroptosis
Cell Death and Disease, 2022 Retinal pigment epithelium (RPE) degeneration plays an important role in a group of retinal disorders such as retinal degeneration (RD) and age-related macular degeneration (AMD). The mechanism of RPE cell death is not yet fully elucidated.
Ming Yang +7 more
semanticscholar +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2022 Significance Retinal degenerative diseases affect specific regions of the retinal pigment epithelium (RPE), suggesting the presence of functionally different RPE subpopulations.
D. Ortolan +9 more
semanticscholar +1 more source
Sodium iodate induces ferroptosis in human retinal pigment epithelium ARPE-19 cells
Cell Death and Disease, 2021 Sodium iodate (SI) is a widely used oxidant for generating retinal degeneration models by inducing the death of retinal pigment epithelium (RPE) cells. However, the mechanism of RPE cell death induced by SI remains unclear. In this study, we investigated
Binghua Liu +11 more
semanticscholar +1 more source
Nature Communications, 2021 There are currently no treatments for geographic atrophy, the advanced form of age-related macular degeneration. Hence, innovative studies are needed to model this condition and prevent or delay its progression.
A. Senabouth +29 more
semanticscholar +1 more source
Role of Epithelial-Mesenchymal Transition in Retinal Pigment Epithelium Dysfunction
Frontiers in Cell and Developmental Biology, 2020 Retinal pigment epithelial (RPE) cells maintain the health and functional integrity of both photoreceptors and the choroidal vasculature. Loss of RPE differentiation has long been known to play a critical role in numerous retinal diseases, including ...
Mi Zhou +6 more
semanticscholar +1 more source
Clinical and Experimental Ophthalmology, 2020 Age‐related macular degeneration (AMD) is a progressive degenerative disease that is the leading cause of vision loss in the elderly population.
Shreya Somasundaran +3 more
semanticscholar +1 more source