Results 61 to 70 of about 91,639 (372)

BEST1 novel mutation causes Bestrophinopathies in six families with distinct phenotypic diversity

Molecular Genetics &Genomic Medicine, Volume 11, Issue 1, January 2023., 2023
BEST1 novel mutation causes Bestrophinopathies in six families with distinct phenotypic diversity. Abstract Purpose To report novel BEST1 variants in six Chinese families with bestrophinopathies of two different inheritance modes and analyze the intrafamilial phenotypic diversity.
Shangying Yang, Zhen Li, Wanyu Cheng, Meijiao Ma, Rui Qi, Xue Rui, Yinghua Ren, Xunlun Sheng, Weining Rong   +8 more
wiley   +1 more source

Transscleral Optical Phase Imaging of the Human Retina - TOPI [PDF]

, 2019
The in vivo observation of the human retina at the cellular level is crucial to detect lesions before irreversible visual loss occurs, to follow the time course of retinal diseases and to evaluate and monitor the early effects of treatments. Despite the phenomenal advances in optical coherence tomography (OCT) and adaptive optics systems, in vivo ...
arxiv   +1 more source

nnUNet RASPP for Retinal OCT Fluid Detection, Segmentation and Generalisation over Variations of Data Sources [PDF]

arXiv, 2023
Retinal Optical Coherence Tomography (OCT), a noninvasive cross-sectional scan of the eye with qualitative 3D visualization of the retinal anatomy is use to study the retinal structure and the presence of pathogens. The advent of the retinal OCT has transformed ophthalmology and it is currently paramount for the diagnosis, monitoring and treatment of ...
arxiv  

In Vivo Multimodal Imaging of Drusenoid Lesions in Rhesus Macaques. [PDF]

, 2017
Nonhuman primates are the only mammals to possess a true macula similar to humans, and spontaneously develop drusenoid lesions which are hallmarks of age-related macular degeneration (AMD).
Cunefare, David, Farsiu, Sina, Garzel, Laura, Munevar, Christian, Roberts, Jeffrey, Thomasy, Sara, Tieu, Eric, Wong, Brittany, Yiu, Glenn   +8 more
core   +2 more sources

Retinal Pigment Epithelium Lipofuscin Proteomics [PDF]

Molecular & Cellular Proteomics, 2008
Lipofuscin accumulates with age in the retinal pigment epithelium (RPE) in discrete granular organelles and may contribute to age-related macular degeneration. Because previous studies suggest that lipofuscin contains protein that may impact pathogenic mechanisms, we pursued proteomics analysis of lipofuscin.
Xiaorong Gu, Mary E. Rayborn, Bogdan G. Gugiu, Michael E. Boulton, Michael E. Boulton, John S. Crabb, Janet R. Sparrow, Kutralanathan Renganathan, John W. Crabb, John W. Crabb, Kwok-Peng Ng, Robert G. Salomon, M. Davies, Vera L. Bonilha, Malgorzata Barbara Rozanowska, Joe G. Hollyfield, Joe G. Hollyfield, So Ra Kim   +17 more
openaire   +3 more sources

In Vitro Gene Delivery in Retinal Pigment Epithelium Cells by Plasmid DNA-Wrapped Gold Nanoparticles

Genes, 2019
Many rare diseases course with affectation of neurosensory organs. Among them, the neuroepithelial retina is very vulnerable due to constant light/oxidative stress, but it is also the most accessible and amenable to gene manipulation.
S. Trigueros, Elena B. Domènech, V. Toulis, G. Marfany   +3 more
semanticscholar   +1 more source

On subcellular distribution of the zinc finger 469 protein (ZNF469) and observed discrepancy in the localization of endogenous and overexpressed ZNF469

FEBS Open Bio, EarlyView.
ZNF469 regulates the expression of genes encoding extracellular matrix proteins. Endogenous ZNF469 is predominantly cytoplasmic, while in transfected cells, it forms aggregates reminiscent of biomolecular condensates, located mainly in the nucleus. These condensates exhibit overlapping staining with proteasomes and are also associated with the mitotic ...
Anne Elisabeth Christensen Mellgren, Ileana Cristea, Thomas Stevenson, Endy Spriet, Per Morten Knappskog, Stig Ove Bøe, Harald Kranz, Sushma N. Grellscheid, Eyvind Rødahl   +8 more
wiley   +1 more source

MFGE8 does not influence chorio-retinal homeostasis or choroidal neovascularization in vivo [PDF]

, 2012
Purpose: Milk fat globule-epidermal growth factor-factor VIII (MFGE8) is necessary for diurnal outer segment phagocytosis and promotes VEGF-dependent neovascularization.
A Swaroop, AC Bird, Alfred Lewin, Bertrand Calippe, BL Burgess, C Combadiere, CA Augood, Christophe Combadière, Clotilde Théry, CY Hu, DA Tregouet, David-Alexandre Tregouet, DS Friedman, E Nandrot, EF Nandrot, EF Nandrot, Florian Sennlaub, Francine Behar-Cohen, G Sugano, H Baatz, H Kamizuru, Holger Baatz, JD Stubbs, JS Silvestre, K Atabai, K Oshima, Lucie Poupel, M Houssier, M Jinushi, M Paques, N Kwak, Nicole Keller, PD Sasieni, PJ Rosenfeld, PM D'Cruz, R Hanayama, R Hanayama, R Klein, R Klein, RB Edwards, RL Ceriani, RW Young, Salomon-Yves Cohen, SC Finnemann, Serge Camelo, SH Sarks, Sophie Krumeich, Sophie Lavalette, T Vinding, William Raoul, WR Green, X Ding, Xavier Guillonneau   +52 more
core   +12 more sources

Oxidative stress in retinal pigment epithelium cells increases exosome secretion and promotes angiogenesis in endothelial cells

Journal of Cellular and Molecular Medicine, 2016
The retinal pigment epithelium (RPE), a monolayer located between the photoreceptors and the choroid, is constantly damaged by oxidative stress, particularly because of reactive oxygen species (ROS). As the RPE, because of its physiological functions, is
Sandra Atienzar-Aroca, Miguel Flores-Bellver, G. Serrano-Heras, Natalia Martínez-Gil, J. Barcia, Silvia Aparicio, D. Pérez-Cremades, J. García-Verdugo, M. Diaz-llopis, F. J. Romero, J. Sancho-Pellúz   +10 more
semanticscholar   +1 more source

Disulfide Glass: An Optical Polymer for Commodity Plastics, Precision Optics, and Photonics

Advanced Functional Materials, EarlyView.
From oil and glass refining to high performance commodity polymers with enhanced thermomechanical and optical properties—the synthesis of a new high refractive index, highly transparent optical thermoset polymer is reported, termed, disulfide glass that affords a robust optical glass amenable to fabrication of precision optics and thin film photonic ...
Jake Molineux, Sam W. Durfee, Ramses Hyde, Matthew C. Malaker, Jacob P. Narr, Kyung‐Jo Kim, Roland Himmelhuber, Young‐Jae Kim, Min‐Gap Bog, Byeongjoon Jeong, Woongbi Cho, Jeong Jae Wie, Nithiyaa Bala Krishnan, Yi Yan Yang, Robert A. Norwood, Jeffrey Pyun   +15 more
wiley   +1 more source