Results 81 to 90 of about 91,639 (372)

Photoreceptor Outer Segment-like Structures in Long-Term 3D Retinas from Human Pluripotent Stem Cells. [PDF]

, 2017
The retinal degenerative diseases, which together constitute a leading cause of hereditary blindness worldwide, are largely untreatable. Development of reliable methods to culture complex retinal tissues from human pluripotent stem cells (hPSCs) could ...
Angueyra, Juan M, Ball, John, Grebe, Rhonda, Jones, Bryan W, Kim, Catherine, Li, Wei, Maruotti, Julien A, Sripathi, Srinivasa R, Wahlin, Karl J, Zack, Donald J   +9 more
core   +1 more source

Phagocytosed photoreceptor outer segments activate mTORC1 in the retinal pigment epithelium

Science Signaling, 2018
The metabolic regulator mTORC1 is activated every morning in the retinal pigment epithelium. Activating mTORC1 with phagocytosis Every morning, photoreceptor outer segments in the retina are shed, phagocytosed by the retinal pigment epithelium, and ...
Bo Yu, Anuoluwapo Egbejimi, Rachayata Dharmat, Pei-Min Xu, Zhenyang Zhao, Bo Long, Hongyu Miao, Rui Chen, T. Wensel, Jiyang Cai, Yan Chen   +10 more
semanticscholar   +1 more source

Nanotherapy for Neural Retinal Regeneration

Advanced Science, EarlyView.
Nanotechnology enhances ophthalmic treatments by improving drug delivery and regenerating ocular tissues, combating vision loss from retinal diseases through innovative nano‐systems. This review outlines ocular anatomy, pathology, immune microenvironment, and barriers, detailing nanocarrier characteristics, classification, and preparation methods, and ...
Chuyao Yu, Li Dong, Yujia Lv, Xuhan Shi, Ruiheng Zhang, Wenda Zhou, Haotian Wu, Heyan Li, Yitong Li, Zhou Li, Dan Luo, Wen‐Bin Wei   +11 more
wiley   +1 more source

Gene expression analysis of zebrafish melanocytes, iridophores, and retinal pigmented epithelium reveals indicators of biological function and developmental origin. [PDF]

PLoS ONE, 2013
In order to facilitate understanding of pigment cell biology, we developed a method to concomitantly purify melanocytes, iridophores, and retinal pigmented epithelium from zebrafish, and analyzed their transcriptomes. Comparing expression data from these
Charles W Higdon, Robi D Mitra, Stephen L Johnson   +2 more
doaj   +1 more source

Loss of synchronized retinal phagocytosis and age-related blindness in mice lacking alphavbeta5 integrin. [PDF]

, 2004
Daily phagocytosis by the retinal pigment epithelium (RPE) of spent photoreceptor outer segment fragments is critical for vision. In the retina, early morning circadian photoreceptor rod shedding precedes synchronized uptake of shed photoreceptor ...
Brodie, Scott E, Finnemann, Silvia C, Huang, Xiaozhu, Kim, Yoonhee, Nandrot, Emeline F, Sheppard, Dean   +5 more
core   +1 more source

Retinal pigment epithelium degeneration caused by aggregation of PRPF31 and the role of HSP70 family of proteins [PDF]

, 2020
Background Mutations in pre-mRNA splicing factor PRPF31 can lead to retinitis pigmentosa (RP). Although the exact disease mechanism remains unknown, it has been hypothesized that haploinsufficiency might be involved in the ...
Aramburu, Ana, Bhatia, Vaibhav, Bhattacharya, Shom S, Calado, Sofia, Chakarova, Christina, de la Cerda, Berta, Diez-Lloret, Andrea, Díaz-Corrales, Francisco J, García-Delgado, Ana B, Massalini, Simone, Montero-Sánchez, Adoración, Rodríguez-Bocanegra, Eduardo, Rodríguez-Martínez, Daniel, Valdés-Sánchez, Lourdes   +13 more
core   +2 more sources

Reticular Dystrophy of the Retinal Pigment Epithelium

Journal of the Formosan Medical Association, 2007
A laser flare-cell meter was used to examine blood-aqueous barrier function in a 57-year-old male patient who had typical reticular dystrophy of the retinal pigment epithelium with a bilateral hyperpigmented reticular pattern at the posterior pole in both eyes.
I-More Fan, Tzu-Hsun Tsai, Ping-Kang Hou, Muh-Shy Chen, Ching-Chung Chang   +4 more
openaire   +4 more sources

Associations Between Retinal Pigment Epithelium and Drusen Volume Changes During the Lifecycle of Large Drusenoid Pigment Epithelial Detachments

Investigative Ophthalmology and Visual Science, 2016
Purpose Drusenoid pigment epithelial detachments (PEDs) are a defined path to atrophy in age-related macular degeneration (AMD). We analyzed the relationships between retinal pigment epithelium (RPE) and drusen volume changes during the PED lifecycle ...
Chandrakumar Balaratnasingam, L. Yannuzzi, C. Curcio, William H. Morgan, G. Querques, V. Capuano, E. Souied, Jesse J. Jung, K. Freund   +8 more
semanticscholar   +1 more source

Delivery of Human iPSC‐Derived RPE Cells in Healthy Minipig Retina Results in Interaction Between Photoreceptors and Transplanted Cells

Advanced Science, EarlyView.
Human induced pluripotent stem cell‐derived retinal pigment epithelial (hiPSC‐RPE) cells, cultured on a clinically relevant PDLLA scaffold, are transplanted into immunosuppressed minipigs. The study demonstrates the viability, integration, and preservation of RPE‐specific features without gliosis or neuroinflammation, supporting their potential as a ...
Anna Macečková Brymová, Francisco Javier Rodriguez‐Jimenez, Annika Konrad, Yaroslav Nemesh, Muhammed Arshad Thottappali, Ana Artero‐Castro, Ruslan Nyshchuk, Anastasiia Kolesnikova, Brigitte Müller, Hana Studenovska, Jana Juhasova, Stefan Juhas, Ivona Valekova, Dunja Lukovic, Claudia Aleman, Taras Ardan, Saskia Drutovič, Jan Motlik, Zdenka Ellederova, Zbinek Straňák, Miroslav Veith, Lyubomyr Lytvynchuk, Ruchi Sharma, Kapil Bharti, Goran Petrovski, Pavla Jendelova, Knut Stieger, Slaven Erceg   +27 more
wiley   +1 more source

Needle detection and localisation for robot‐assisted subretinal injection using deep learning

CAAI Transactions on Intelligence Technology, EarlyView., 2023
Abstract Subretinal injection is a complicated task for retinal surgeons to operate manually. In this paper we demonstrate a robust framework for needle detection and localisation in robot‐assisted subretinal injection using microscope‐integrated Optical Coherence Tomography with deep learning.
Mingchuan Zhou, Xiangyu Guo, Matthias Grimm, Elias Lochner, Zhongliang Jiang, Abouzar Eslami, Juan Ye, Nassir Navab, Alois Knoll, Mohammad Ali Nasseri   +9 more
wiley   +1 more source