Results 81 to 90 of about 138,851 (338)

Clinicopathological correlation of parapapillary atrophy in monkeys with experimental glaucoma and temporary central retinal artery occlusion

Indian Journal of Ophthalmology, 2014
Objective: To investigate the clinicopathological correlation of parapapillary atrophy. Materials and Methods: The study included 16 eyes of rhesus monkeys (Macaca mulatta) - 4 eyes with experimental glaucoma, 11 eyes after experimental temporary ...
Jost B Jonas, Sohan S Hayreh, Yong Tao
doaj   +1 more source

In Vitro Gene Delivery in Retinal Pigment Epithelium Cells by Plasmid DNA-Wrapped Gold Nanoparticles

Genes, 2019
Many rare diseases course with affectation of neurosensory organs. Among them, the neuroepithelial retina is very vulnerable due to constant light/oxidative stress, but it is also the most accessible and amenable to gene manipulation.
S. Trigueros, Elena B. Domènech, V. Toulis, G. Marfany   +3 more
semanticscholar   +1 more source

Ocular immune privilege and retinal pigment epithelial cells.

Journal of Leukocyte Biology, 2023
The ocular tissue microenvironment is immune-privileged and uses multiple immunosuppressive mechanisms to prevent the induction of inflammation. The retinal pigment epithelium plays an essential role in ocular immune privilege.
Yuxiang Du, Bo Yan
semanticscholar   +1 more source

A New Era for Using Natural Pigments: The Case of the C50 Carotenoid Called Bacterioruberin

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Haloarchaea are extremophilic microorganisms belonging to the Archaea domain that require high salt concentrations to live, thus inhabiting ecosystems like salty ponds, salty marshes, or extremely salty lagoons. They are more abundant and widely distributed worldwide than initially expected.
Micaela Giani, Elena Valdés, José María Miralles‐Robledillo, Guillermo Martínez, Carmen Pire, Rosa María Martínez‐Espinosa   +5 more
wiley   +1 more source

Japanese quail (Coturnix japonica) as a model of accelerated aging of human retinal processes. Report 1. Assessment of the age RPE lipofuscin accumulation depending on the retinal amount of oxycarotenoids

Офтальмохирургия, 2013
Purpose. Using the eyes of quails C. japonic as a model system to evaluate age-related accumulation of lipofuscin granules in the cells of the retinal pigment epithelium depending on the level of oxycarotenoids content in the retina and in the retinal ...
P.P. Zak, A.V. Zykova, N.N. Trofimova, M.A. Ostrovsky   +3 more
doaj  

Metabolic Deregulation of the Blood-Outer Retinal Barrier in Retinitis Pigmentosa

Cell Reports, 2019
Summary: Retinitis pigmentosa (RP) initiates with diminished rod photoreceptor function, causing peripheral and night-time vision loss. However, subsequent loss of cone function and high-resolution daylight and color vision is most debilitating.
Wei Wang, Ashwini Kini, Yekai Wang, Tingting Liu, Yao Chen, Eric Vukmanic, Douglas Emery, Yongqing Liu, Xiaoqin Lu, Lei Jin, San Joon Lee, Patrick Scott, Xiao Liu, Kevin Dean, Qingxian Lu, Enzo Fortuny, Robert James, Henry J. Kaplan, Jianhai Du, Douglas C. Dean   +19 more
doaj   +1 more source

Morphologic Criteria of Lesion Activity in Neovascular Age-Related Macular Degeneration: A Consensus Article [PDF]

, 2017
Intravitreal antivascular endothelial growth factor drugs represent the current standard of care for neovascular age-related macular degeneration (nAMD).
Elena Gusson, Giacomo Panozzo, Giorgio Boschi, Giuseppe Scarpa, Nicola Zemella, null null, Sandro Saviano, Stefania Miotto, Stefano Piermarocchi   +8 more
core   +1 more source

Age‐related differences in hydroxychloroquine‐associated adverse events: A pharmacovigilance study based on the FDA Adverse Event Reporting System

British Journal of Clinical Pharmacology, EarlyView.
Aims This real‐world pharmacovigilance study utilizes FDA Adverse Event Reporting System (FAERS) data (2004–2024) to characterize age‐related disparities in hydroxychloroquine (HCQ)‐associated adverse events (AEs), addressing gaps in age‐stratified risk assessment. Methods Disproportionality analysis (reporting odds ratios, RORs) and parametric Weibull
Guanghan Sun, Jingrong Yang, Lei Wan, Xia Xu, Jing Wang   +4 more
wiley   +1 more source

Single-cell transcriptome of the mouse retinal pigment epithelium in response to a low-dose of doxorubicin

Communications Biology, 2022
Single cell transcriptomics pinpoints a cell subpopulation that could be involved in inducing cellular senescence of the retinal pigment epithelium, which in turn may construe retinal degenerative disease.
Hyungwoo Lee, Ho-Yeon Lee, Jae-Byoung Chae, Chul-Woo Park, Chaekyu Kim, Ja-Hyoung Ryu, Jiwon Jang, Namshin Kim, Hyewon Chung   +8 more
doaj   +1 more source

Nanostructured drug delivery systems for posterior segment eye diseases: Strategies to defy ocular barriers

BMEMat, EarlyView.
Efficient drug delivery to the posterior segment of the eye has long been a challenging issue due to the complex ocular barriers. The review focuses on the promise held by nanoplatforms for barrier penetration and the key mechanisms involved, also highlighting their advantages in achieving efficient drug delivery and superior treatment of PSEDs ...
Yifan Shen, Ying Yao, Yan Zhang, Xinyu Shi, Ling Bai, Yang Zhong, Yan Zhang, Kun Zhang   +7 more
wiley   +1 more source