A novel source of methylglyoxal and glyoxal in retina: implications for age-related macular degeneration. [PDF]
PLoS ONE, 2012 Aging of retinal pigment epithelial (RPE) cells of the eye is marked by accumulations of bisretinoid fluorophores; two of the compounds within this lipofuscin mixture are A2E and all-trans-retinal dimer.
Kee Dong Yoon +4 more
doaj +1 more source
Frontiers in Medicine, 2022 Age-related macular degeneration (AMD) is a chronic multifactorial eye disease representing the primary cause of vision loss in people aged 60 years and older.
Marco Lombardo +5 more
doaj +1 more source
Human Cellular Retinaldehyde-Binding Protein Has Secondary Thermal 9- cis -Retinal Isomerase Activity [PDF]
, 2014 Cellular retinaldehyde-binding protein (CRALBP) chaperones 11-cis-retinal to convert opsin receptor molecules into photosensitive retinoid pigments of the eye. We report a thermal secondary isomerase activity of CRALBP when bound to 9-cis-retinal. UV/vis
Cascella, Michele +38 more
core +2 more sources
Reversible Photoreaction of a Retinal Photoisomerase, Retinal G‑Protein-Coupled Receptor RGR
, 2023 Retinal G-protein-coupled receptor (RGR) plays a crucial role in the visual system of vertebrates as a retinal photoisomerase, which isomerizes all-trans-retinal to 11-cis-retinal to maintain the photosensitivity of visual rhodopsins.
Takashi Nagata (336038) +5 more
core +1 more source
CryoEM structure and small-angle X-ray scattering analyses of porcine retinol-binding protein 3
Open BiologyThe vertebrate visual cycle hinges on enzymatically converting all-trans-retinol (at-ROL) into 11-cis-retinal (11c-RAL), the chromophore that binds to opsins in photoreceptors, forming light-responsive pigments.
Vineeta Kaushik +7 more
doaj +1 more source
RETINAL SPARING BY SELECTIVE RETINAL PIGMENT EPITHELIAL PHOTOCOAGULATION [PDF]
Evidence-Based Eye Care, 1999 To investigate whether photocoagulation of the retinal pigment epithelium is possible with sparing of the photoreceptors.Mild laser effects of a neodymium:yttrium-lithium-fluoride (Nd:YLF) laser (527 nm) were applied to 17 patients. To establish the necessary energy, test exposures were performed to the lower macula (laser variables: 1.7 microseconds ...
J, Roider +4 more
openaire +2 more sources
Early 20th C Russian painting? Raman identification of modern pigments on a pastel supposedly Painted by the renowned artist Natalia Goncharova [PDF]
, 2014 A pastel painting considered to have been painted by renowned Russian artist Natalia Goncharova in c. 1913 has been shown by Raman microscopy of the pigments to have been painted after 1952, with the identification of dioxazine violet.
Robin J. H. Clark +5 more
core +1 more source
Self‐Sealing Microneedles Improve Precision and Reduce Reflux in Subretinal Cell Transplantation
Advanced Materials Technologies, EarlyView.Ultrafine 49G microneedles enable subretinal delivery of induced pluripotent stem cell‐derived retinal pigment epithelial cells through a 50 µm outer diameter tip. Compared with conventional 38G microcannulas, these microneedles reduce cell suspension reflux in a rabbit model, highlighting the potential of microinvasive delivery instruments to improve ...
Jared Ching +9 more
wiley +1 more source
Solid Harmonic Wavelet Bispectrum for Image Analysis
Advanced Science, EarlyView.The Solid Harmonic Wavelet Bispectrum (SHWB), a rotation‐ and translation‐invariant descriptor that captures higher‐order (phase) correlations in signals, is introduced. Combining wavelet scattering, bispectral analysis, and group theory, SHWB achieves interpretable, data‐efficient representations and demonstrates competitive performance across texture,
Alex Brown +3 more
wiley +1 more source
Why 11-cis-Retinal? Why Not 7-cis-, 9-cis-, or 13-cis-Retinal in the Eye?
, 2016 One of the basic and unresolved puzzles in the chemistry of vision concerns the natural selection of 11-cis-retinal as the light-sensing chromophore in visual pigments.
Sivakumar Sekharan (1268745) +1 more
core +1 more source