Results 31 to 40 of about 19,821 (304)

A new mouse model for retinal degeneration due to Fam161a deficiency

open access: yesScientific Reports, 2021
FAM161A mutations are the most common cause of inherited retinal degenerations in Israel. We generated a knockout (KO) mouse model, Fam161a tm1b/tm1b , lacking the major exon #3 which was replaced by a construct that include LacZ under the expression of ...
Avigail Beryozkin   +7 more
doaj   +1 more source

Structure and Conformation of the Carotenoids in Human Retinal Macular Pigment. [PDF]

open access: yesPLoS ONE, 2015
Human retinal macular pigment (MP) is formed by the carotenoids lutein and zeaxanthin (including the isomer meso-zeaxanthin). MP has several functions in improving visual performance and protecting against the damaging effects of light, and MP levels are
Ana-Andreea Arteni   +7 more
doaj   +1 more source

Vitamin A deficiency affects gene expression in the Drosophila melanogaster head

open access: yesG3: Genes, Genomes, Genetics, 2021
Insufficient dietary intake of vitamin A causes various human diseases. For instance, chronic vitamin A deprivation causes blindness, slow growth, impaired immunity, and an increased risk of mortality in children.
Deepshe Dewett   +4 more
doaj   +1 more source

Photo-damage, photo-protection and age-related macular degeneration [PDF]

open access: yes, 2015
Age-related macular degeneration (AMD) is a degenerative retinal disease that causes blindness in people 60-65 years and older, with the highest prevalence appearing in people 90 years-old or more.
Marquioni Ramella, Melisa Daniela   +1 more
core   +1 more source

Probing how initial retinal configuration controls photochemical dynamics in retinal proteins

open access: yesEPJ Web of Conferences, 2013
The effects of the initial retinal configuration and the active isomerization coordinate on the photochemistry of retinal proteins (RPs) are assessed by comparing photochemical dynamics of two stable retinal ground state configurations (all-trans,15-anti
Sheves M.   +6 more
doaj   +1 more source

Diagnosis of Retinitis Pigmentosa from Retinal Images [PDF]

open access: yesInternational Journal of Electronics and Telecommunications, 2019
Retinitis pigmentosa is a genetic disorder that results in nyctalopia and its progression leads to complete loss of vision. The analysis and the study of retinal images are necessary, so as to help ophthalmologist in early detection of the retinitis ...
Giritharan Ravichandran   +2 more
doaj   +1 more source

Properties of Cephalopod Skin Ommochromes to Inhibit Free Radicals, and the Maillard Reaction and Retino-Protective Mechanisms in Cellular Models Concerning Oxidative Stress, Angiogenesis, and Inflammation

open access: yesAntioxidants, 2022
Ommochromes are pigments of invertebrates that exhibit oxidative stress protection. The aim of this study was to investigate ommochromes extracted from cephalopod’s skin for their ability to inhibit age-related-macular degeneration (AMD)-related factors ...
Luján Lidianys María Lewis   +11 more
doaj   +1 more source

A two-step method for identifying photopigment opsin and rhodopsin gene sequences underlying human color vision phenotypes. [PDF]

open access: yes, 2020
PurposeTo present a detailed, reliable long range-PCR and sequencing (LR-PCR-Seq) procedure to identify human opsin gene sequences for variations in the long wavelength-sensitive (OPN1LW), medium wavelength-sensitive (OPN1MW), short wavelength-sensitive (
Atilano, Shari R   +3 more
core   +1 more source

Spectral Tuning Mechanism of Primate Blue-sensitive Visual Pigment Elucidated by FTIR Spectroscopy

open access: yesScientific Reports, 2017
Protein-bound water molecules are essential for the structure and function of many membrane proteins, including G-protein-coupled receptors (GPCRs). Our prior work focused on studying the primate green- (MG) and red- (MR) sensitive visual pigments using ...
Kota Katayama   +4 more
doaj   +1 more source

Photoreceptor Outer Segment-like Structures in Long-Term 3D Retinas from Human Pluripotent Stem Cells. [PDF]

open access: yes, 2017
The retinal degenerative diseases, which together constitute a leading cause of hereditary blindness worldwide, are largely untreatable. Development of reliable methods to culture complex retinal tissues from human pluripotent stem cells (hPSCs) could ...
Angueyra, Juan M   +9 more
core   +1 more source

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