A new mouse model for retinal degeneration due to Fam161a deficiency
Scientific Reports, 2021 FAM161A mutations are the most common cause of inherited retinal degenerations in Israel. We generated a knockout (KO) mouse model, Fam161a tm1b/tm1b , lacking the major exon #3 which was replaced by a construct that include LacZ under the expression of ...
Avigail Beryozkin +7 more
doaj +1 more source
Structure and Conformation of the Carotenoids in Human Retinal Macular Pigment. [PDF]
PLoS ONE, 2015 Human retinal macular pigment (MP) is formed by the carotenoids lutein and zeaxanthin (including the isomer meso-zeaxanthin). MP has several functions in improving visual performance and protecting against the damaging effects of light, and MP levels are
Ana-Andreea Arteni +7 more
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Vitamin A deficiency affects gene expression in the Drosophila melanogaster head
G3: Genes, Genomes, Genetics, 2021 Insufficient dietary intake of vitamin A causes various human diseases. For instance, chronic vitamin A deprivation causes blindness, slow growth, impaired immunity, and an increased risk of mortality in children.
Deepshe Dewett +4 more
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Photo-damage, photo-protection and age-related macular degeneration [PDF]
, 2015 Age-related macular degeneration (AMD) is a degenerative retinal disease that causes blindness in people 60-65 years and older, with the highest prevalence appearing in people 90 years-old or more.
Marquioni Ramella, Melisa Daniela +1 more
core +1 more source
Probing how initial retinal configuration controls photochemical dynamics in retinal proteins
EPJ Web of Conferences, 2013 The effects of the initial retinal configuration and the active isomerization coordinate on the photochemistry of retinal proteins (RPs) are assessed by comparing photochemical dynamics of two stable retinal ground state configurations (all-trans,15-anti
Sheves M. +6 more
doaj +1 more source
Diagnosis of Retinitis Pigmentosa from Retinal Images [PDF]
International Journal of Electronics and Telecommunications, 2019 Retinitis pigmentosa is a genetic disorder that results in nyctalopia and its progression leads to complete loss of vision. The analysis and the study of retinal images are necessary, so as to help ophthalmologist in early detection of the retinitis ...
Giritharan Ravichandran +2 more
doaj +1 more source
Antioxidants, 2022 Ommochromes are pigments of invertebrates that exhibit oxidative stress protection. The aim of this study was to investigate ommochromes extracted from cephalopod’s skin for their ability to inhibit age-related-macular degeneration (AMD)-related factors ...
Luján Lidianys María Lewis +11 more
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A two-step method for identifying photopigment opsin and rhodopsin gene sequences underlying human color vision phenotypes. [PDF]
, 2020 PurposeTo present a detailed, reliable long range-PCR and sequencing (LR-PCR-Seq) procedure to identify human opsin gene sequences for variations in the long wavelength-sensitive (OPN1LW), medium wavelength-sensitive (OPN1MW), short wavelength-sensitive (
Atilano, Shari R +3 more
core +1 more source
Spectral Tuning Mechanism of Primate Blue-sensitive Visual Pigment Elucidated by FTIR Spectroscopy
Scientific Reports, 2017 Protein-bound water molecules are essential for the structure and function of many membrane proteins, including G-protein-coupled receptors (GPCRs). Our prior work focused on studying the primate green- (MG) and red- (MR) sensitive visual pigments using ...
Kota Katayama +4 more
doaj +1 more source
Photoreceptor Outer Segment-like Structures in Long-Term 3D Retinas from Human Pluripotent Stem Cells. [PDF]
, 2017 The retinal degenerative diseases, which together constitute a leading cause of hereditary blindness worldwide, are largely untreatable. Development of reliable methods to culture complex retinal tissues from human pluripotent stem cells (hPSCs) could ...
Angueyra, Juan M +9 more
core +1 more source