Results 11 to 20 of about 8,879 (266)

The First Homozygote Mutation c.499G>T (Asp167Tyr) in the RPE65 Gene Encoding Retinoid Isomerohydrolase Causing Retinal Dystrophy

open access: yesCurrent Issues in Molecular Biology, 2022
RPE65, an abundant membrane-associated protein present in the retinal pigment epithelium (RPE), is a vital retinoid isomerase necessary for regenerating 11-cis-retinaldehyde from all-trans retinol in the visual cycle.
Mirjana Bjeloš   +4 more
doaj   +1 more source

The novel visual cycle inhibitor (±)-RPE65-61 protects retinal photoreceptors from light-induced degeneration

open access: yesPLoS ONE, 2022
The visual cycle refers to a series of biochemical reactions of retinoids in ocular tissues and supports the vision in vertebrates. The visual cycle regenerates visual pigments chromophore, 11-cis-retinal, and eliminates its toxic byproducts from the ...
Yuhong Wang   +8 more
doaj   +2 more sources

Histopathology of Pigment dispersion syndrome and glaucoma

open access: yesOman Journal of Ophthalmology, 2023
Pigment dispersion syndrome (PDS) can have varied manifestations. Anterior and posterior segment involvement by dispersed pigments was documented in gross pathology and by staining under microscopy.
Dipankar Das   +5 more
doaj   +1 more source

The Physical Mechanism for Retinal Discrete Dark Noise: Thermal Activation or Cellular Ultraweak Photon Emission? [PDF]

open access: yesPLoS ONE, 2016
For several decades the physical mechanism underlying discrete dark noise of photoreceptors in the eye has remained highly controversial and poorly understood.
Vahid Salari   +4 more
doaj   +1 more source

Familial grouped pigmentation of the retinal pigment epithelium. [PDF]

open access: yesBritish Journal of Ophthalmology, 1988
Grouped pigmentation of the retinal pigment epithelium was found in a father and his son. They had a normal resting potential on the electro-oculogram, but the son had a lower normal light rise. We believe this is the first description of familial grouped pigmentation.
de Jong, P.T.V.M., Delleman, J.W.
openaire   +3 more sources

Retinoids in the visual cycle: role of the retinal G protein-coupled receptor

open access: yesJournal of Lipid Research, 2021
Driven by the energy of a photon, the visual pigments in rod and cone photoreceptor cells isomerize 11-cis-retinal to the all-trans configuration.
Elliot H. Choi   +4 more
doaj   +1 more source

Preclinical pharmacology of a lipophenol in a mouse model of light-induced retinopathy

open access: yesExperimental and Molecular Medicine, 2020
Experimental & Molecular Medicine: Vision loss: Shedding light on how to prevent retinal damage Treating retinal damage in both aging and young patients might now be easier, thanks to treatment with a lipophenol, an omega-3 fatty acid linked to an ...
Nicolas Taveau   +10 more
doaj   +1 more source

Xanthophyll pigments dietary supplements administration and retinal health in the context of increasing life expectancy trend

open access: yesFrontiers in Nutrition, 2023
IntroductionMedicine faces nowadays the trend of increasing life expectancy of human population, with the resulting increase of degenerative age related diseases prevalence, combined with the risks of less tempered sun radiations environment exposure ...
Sanda Jurja   +5 more
doaj   +1 more source

Multi-Functional OCT Enables Longitudinal Study of Retinal Changes in a VLDLR Knockout Mouse Model. [PDF]

open access: yesPLoS ONE, 2016
We present a multi-functional optical coherence tomography (OCT) imaging approach to study retinal changes in the very-low-density-lipoprotein-receptor (VLDLR) knockout mouse model with a threefold contrast.
Marco Augustin   +9 more
doaj   +1 more source

Macular changes of neuromyelitis optica through spectral-domain optical coherence tomography [PDF]

open access: yesInternational Journal of Ophthalmology, 2016
AIM: To evaluate the thickness of the retinal layers in the macula using spectral-domain optical coherence tomography (SD-OCT) in patients with neuromyelitis optica (NMO).
Lu Cheng   +4 more
doaj   +1 more source

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