Results 71 to 80 of about 283,262 (306)

In vivo imaging of the human eye using a 2-photon-excited fluorescence scanning laser ophthalmoscope

The Journal of Clinical Investigation, 2022
Background Noninvasive assessment of metabolic processes that sustain regeneration of human retinal visual pigments (visual cycle) is essential to improve ophthalmic diagnostics and to accelerate development of new treatments to counter retinal diseases.
Jakub Boguslawski, Grazyna Palczewska, Slawomir Tomczewski, Jadwiga Milkiewicz, Piotr Kasprzycki, Dorota Stachowiak, Katarzyna Komar, Marcin J. Marzejon, Bartosz L. Sikorski, Arkadiusz Hudzikowski, Aleksander Głuszek, Zbigniew Łaszczych, Karol Karnowski, Grzegorz Soboń, Krzysztof Palczewski, Maciej Wojtkowski   +15 more
doaj   +1 more source

Chlorophyll derivatives as visual pigments for super vision in the red [PDF]

, 2007
The primary event in vision is light-initiated activation of visual pigments. All visual pigments consist of the protein opsin bound to 11-cis-retinal and are responsible for initiating the transformation of light into an electrical signal.
Sparrow, Janet R., Jockusch, Steffen, Zhou, Jilin, Nakanishi, Koji, Turro, Nicholas J., Washington, Ilyas   +5 more
core   +1 more source

A Mechanistic Dissection of Multifaceted Complement Attack in Age‐Related Macular Degeneration Reveals the Superiority of C3 Inhibition

Advanced Science, EarlyView.
Complement‐mediated RPE degeneration extends beyond terminal MAC injury. A four‐hit mechanism emerges in which C3a and C5a disrupt mitochondrial function, while C3b and MAC compromise the phagolysosomal system. Upstream C3 inhibition suppresses this full spectrum of pathogenic effectors, providing broader cellular protection than C5 blockade.
Zhidong Chen, Mingshuang Wang, Huiqin Liu, Feng Qian   +3 more
wiley   +1 more source

Retinal arterioles narrow with increasing duration of anti-retroviral therapy in HIV infection: a novel estimator of vascular risk in HIV? [PDF]

, 2012
OBJECTIVES: HIV infection is associated with an increased risk of age-related morbidity mediated by immune dysfunction, atherosclerosis and inflammation.
Pathai, Sophia, Peto, Tunde; id_orcid, Tien Y Wong, Weiss, Helen A, Helen A Weiss, Colin Cook, Cook Colin, Tien Y. Wong, Tunde Peto, Lawn, Stephen D, Gilbert Clare E., Weiss Helen A., Wong Tien Y., Stephen D Lawn, Leris M D'Costa, Clare E. Gilbert, Peto Tunde, Sophia Pathai, Pathai Sophia, Leris M. D’costa, Lawn Stephen D., Cook, Colin, Helen A. Weiss, D’Costa Leris M., Gilbert, Clare E, Stephen D. Lawn, Peto, Tunde, Wong, Tien Y, D'Costa, Leris M, Clare E Gilbert, Cook, C., Pathai, S., Peto, T., Weiss, H.A., Lawn, S.D., D'Costa, L.M., Gilbert, C.E., Wong, T.Y.   +37 more
core   +1 more source

Engineering Intelligent iPSC Biomanufacturing: Integrating Robotic Automation, AI, and Process Control

Advanced Intelligent Systems, EarlyView.
This review highlights recent advances in automated iPSC culture systems integrating robotics, advanced imaging, artificial intelligence, and process control. These technologies improve reproducibility, scalability, and quality in cell expansion, differentiation, and real‐time monitoring, while emerging AI‐enabled and closed‐loop approaches offer new ...
Hyoryong Lee, Roma Desai, Byunggik Kim, Deok‐Ho Kim   +3 more
wiley   +1 more source

Carotenoid Biosynthesis in Fusarium

Journal of Fungi, 2017
Many fungi of the genus Fusarium stand out for the complexity of their secondary metabolism. Individual species may differ in their metabolic capacities, but they usually share the ability to synthesize carotenoids, a family of hydrophobic terpenoid ...
Javier Avalos, Javier Pardo-Medina, Obdulia Parra-Rivero, Macarena Ruger-Herreros, Roberto Rodríguez-Ortiz, Dámaso Hornero-Méndez, María Carmen Limón   +6 more
doaj   +1 more source

AI‐Powered Smart Displays and AR Glasses: Perspectives and Challenges

Advanced Intelligent Systems, EarlyView.
This perspective examines how AI is reshaping smart displays and AR glasses. The latest in image‐quality enhancement, sensor‐integrated display optimization, and physiological sensing in display systems, followed by AI‐assisted AR technologies including waveguide optimization, image compensation, foveated rendering, and multimodal sensing, is discussed.
Luke Benoit, Yizhou Qian, Yi‐Chien Chen, Ziyang Shen, Po‐Sheng Chiu, Youngeon Lee, Cheng‐Han Ke, Chih‐Lung Lin, Shin‐Tson Wu   +8 more
wiley   +1 more source

Understanding the spacing of placodes in the eye: A comparative study across age and species

The Anatomical Record, EarlyView.
Abstract The conjunctival placodes of the avian eye form in an intriguing and conserved sequence in a circular annulus around the cornea. These 13–16 placodes develop into papillae that are essential for inducing underlying intramembranous flat bones, known as scleral ossicles, which form an important part of the ocular skeleton.
Florence Joseph, Tamara A. Franz‐Odendaal   +1 more
wiley   +1 more source

Ocular morphology and morphometry of the great egret (Ardea alba): A comprehensive anatomical description

The Anatomical Record, EarlyView.
Abstract Ardea alba (Linnaeus, 1758) is widely distributed, yet knowledge of its ocular morphology remains limited. This study described the morphometry and morphology of the eyeball and its accessory glands in six specimens using radiography, morphometry, light and scanning electron microscopy, and 3D scanning.
Julia Vaz Feio, Max Alex Santos Ferreira, Iara Fernanda Lima do Espírito Santo, Elane Guerreiro Giese, Érika Branco, Antônio Basílio Guerreiro Junior, Ana Rita de Lima   +6 more
wiley   +1 more source

The cone visual cycle and its disorders: insights from zebrafish

Frontiers in Molecular Neuroscience
Continuous vision relies on the recycling of visual pigment chromophore, which is photoisomerized during the process of vision. In vertebrates, this recycling is mediated by a complex network of biochemical reactions distributed across different cell ...
Ioanna S. Koutroumpa, Stephan C. F. Neuhauss   +1 more
doaj   +1 more source