Results 81 to 90 of about 283,262 (306)

Diacylglycerol O-acyltransferase type-1 synthesizes retinyl esters in the retina and retinal pigment epithelium.

PLoS ONE, 2015
Retinyl esters represent an insoluble storage form of vitamin A and are substrates for the retinoid isomerase (Rpe65) in cells of the retinal pigment epithelium (RPE).
Joanna J Kaylor, Roxana A Radu, Nicholas Bischoff, Jacob Makshanoff, Jane Hu, Marcia Lloyd, Shannan Eddington, Tran Bianconi, Dean Bok, Gabriel H Travis   +9 more
doaj   +1 more source

Spectral Tuning of Deep Red Cone Pigments

, 2016
Visual pigments are G-protein-coupled receptors that provide a critical interface between organisms and their external environment. Natural selection has generated vertebrate pigments that absorb light from the far-UV (360 nm) to the deep red (630 nm ...
Robert R. Birge (1309212), Lavoisier S. Ramos (53578), Jhenny F. Galan (1777465), Tabitha L. Amora (2225203)   +3 more
core   +1 more source

Engineering Biology Beyond Single Genes: Advances and Challenges in Multiplex Genome Editing

Animal Research and One Health, EarlyView.
Multiplex genome editing is transforming genome engineering from single‐gene perturbation to network‐level control, yet its broader application remains limited by challenges in gRNA array engineering, delivery technologies, and safety management. Emerging AI‐driven approaches are accelerating guide RNA design and CRISPR effector optimization for ...
Linli Wang, Yongbin Liu, Hongbing Han
wiley   +1 more source

Macular pigment optical density correlates inversely with intraretinal light scatter in support of a polarization-dependent glare-reduction mechanism

Scientific Reports
Macular pigments are thought to protect the retina from photo-oxidative stress and enhance visual performance by filtering short-wavelength light. Their role in mitigating intraretinal light scatter remains uncertain.
Gary P. Misson, Stephen J. Anderson, Richard A. Armstrong, Rebekka Heitmar   +3 more
doaj   +1 more source

Bilateral Paracentral Climatic Droplet Keratopathy in Congenital Methemoglobinemia

TNOA Journal of Ophthalmic Science and Research
A 59-year-old woman, who is a known case of congenital methemoglobinemia, came with complaints of diminision of vision in both eyes for 2 years. The patient noticed whitish discolouration of cornea since teenage and did not undergo any ophthalmic ...
S Saudhamini, Vidhya Devi Ramasamy, M Uma Priya, P. K. Nerenjhanna   +3 more
doaj   +1 more source

The retinal G protein-coupled receptor (RGR) enhances isomerohydrolase activity independent of light.

, 2005
Rod and cone visual pigments use 11-cis-retinal, a vitamin A derivative, as their chromophore. Light isomerizes 11-cis- into all-trans-retinal, triggering a conformational transition of the opsin molecule that initiates phototransduction.
Remé CE, Wenzel A, Seeliger MW, Samardzija M, Pugh EN, Oberhauser V, Lamb TD, Grimm C, von Lintig J, Fahl E   +9 more
core   +1 more source

Age‐related differences in hydroxychloroquine‐associated adverse events: A pharmacovigilance study based on the FDA Adverse Event Reporting System

British Journal of Clinical Pharmacology, EarlyView.
Aims This real‐world pharmacovigilance study utilizes FDA Adverse Event Reporting System (FAERS) data (2004–2024) to characterize age‐related disparities in hydroxychloroquine (HCQ)‐associated adverse events (AEs), addressing gaps in age‐stratified risk assessment. Methods Disproportionality analysis (reporting odds ratios, RORs) and parametric Weibull
Guanghan Sun, Jingrong Yang, Lei Wan, Xia Xu, Jing Wang   +4 more
wiley   +1 more source

Bilateral conjunctival melanocytosis and retinitis pigmentosa

Journal of Clinical Ophthalmology and Research, 2019
Conjunctival pigmented lesions have varied appearances. It arises from the melanocytic or nonmelanocytes. It is rare to find conjunctival melanocytosis associated with retinal pigmentary dystrophy.
Rajesh Subhash Joshi, Iqbal Zarir Hussain Bombaywala   +1 more
doaj   +1 more source

RETINAL DISPLACEMENT AFTER RETINECTOMY IN COMPLEX MACULA-INVOLVING RECURRENT RHEGMATOGENOUS RETINAL DETACHMENT

Retinectomy, essential for treating complex rhegmatogenous retinal detachment, significantly risks retinal displacement, detectable through fundus autofluorescence.
Shaheen, Abdulla, Ghalibafan, Seyyedehfatemeh, Grau, Maria Magraner, Yannuzzi, Nicolas A., Sridhar, Jayanth, Leal, Sebastian, Rohowetz, Landon J., Cai, Louis Z.   +7 more
core   +1 more source

Modeling high-resolution SLO and OCT retinal imaging using backscattering of light from elementary sources

, 2015
Photoreceptor imaging is feasible due to refractive-index discontinuities across the retinal layers. These can alter the light distribution at the visual pigments and impact vision. Here, we analyze a lightscattering model for improved retinal analysis.
Vohnsen, Brian, Elaine Wells-Gray, Xu, Heping, Brian Vohnsen, Heping Xu, Alan W. Stitt, Doble, Nathan, Choi, Stacey S., Wells-Gray, Elaine, Stitt, Alan W.; id_orcid, Stacey S. Choi, Nathan Doble   +11 more
core   +1 more source