Results 151 to 160 of about 24,391 (241)

Math5 promotes retinal ganglion cell expression patterns in retinal progenitor cells.

Molecular vision, 2007
To investigate the role of over-expression of Math5 on the retinal ganglion cell (RGC) expression patterns in retinal progenitor cells (RPCs).RPCs were cultured and then transfected by recombinant Math5 plasmid with internal ribosome entry site and enhanced green fluorescent protein (pIRES2-EGFP-Math5; group A), with pIRES2-EGFP transfected (group B ...
Jing, Yao, Xinghuai, Sun, Yang, Wang, Gezhi, Xu, Jiang, Qian   +4 more
openaire   +1 more source

Cilia in Nervous System Development, Function, and Disease

MedComm – Future Medicine, Volume 5, Issue 2, June 2026.
Cilia are evolutionarily conserved organelles that function as essential sensory and motility platforms in the nervous system. This review outlines key cilia‐dependent signaling pathways and their roles in neural development and function. Furthermore, it highlights how ciliary dysfunction can lead to a variety of neurological disorders, known as ...
Qingchao Li, Anqi Zhang, Ting Song
wiley   +1 more source

Pitfalls and missing links in current understanding of 4D genomes

Quantitative Biology, Volume 14, Issue 2, June 2026.
Abstract The spatial and temporal organization of the genome—collectively termed the 4D genome—is pivotal for regulating gene expression, maintaining genome stability, and guiding development. The convergence of chromosome conformation capture technologies, super‐resolution microscopy, and single‐cell epigenomics has transformed our understanding of ...
Michael Q. Zhang
wiley   +1 more source

Characterization of a new murine retinal cell line (MU-PH1) with glial, progenitor and photoreceptor characteristics

, 2013
Unlike fish and amphibians, mammals do not regenerate retinal neurons throughout life. However, neurogenic potential may be conserved in adult mammal retina and it is necessary to identify the factors that regulate retinal progenitor cells (RPC ...
Cuenca, Nicolás, Gozalbo, Daniel, Yáñez, Alberto, Maneu, Victoria, Gómez-Vicente, Violeta, Lax, Pedro, Gil, María Luisa, Murciano, Celia, Flores, Ana   +8 more
core   +1 more source

T Cell Dysfunction in the Acidic Tumor Microenvironment

Acta Physiologica, Volume 242, Issue 6, June 2026.
ABSTRACT Solid tumors are characterized by profound metabolic and vascular abnormalities that generate a hostile tumor microenvironment (TME) marked by extracellular acidosis, hypoxia, and nutrient deprivation. While the consequences of these conditions for cancer cell behavior have been extensively studied, their impact on anti‐tumor immune responses ...
F. B. Christiansen, E. S. Novella, A. V. Lindemann, J. F. H. Cordes, S. F. Pedersen   +4 more
wiley   +1 more source

Advancing Brain and Body Vascular Imaging in Bipolar Disorder: A Report From the International Society for Bipolar Disorders Vascular Task Force

Bipolar Disorders, Volume 28, Issue 4, June 2026.
ABSTRACT Objectives The heart–brain nexus is increasingly recognized as important for human health. Nonetheless, integration of this perspective in research and treatment remains limited in psychiatry, particularly in bipolar disorder (BD). Multisystem vascular imaging may help elucidate mechanisms linking heart and brain health in BD.
Megan Mio, Pao‐Huan Chen, Kody G. Kennedy, Hilary P. Blumberg, David J. Bond, Eric L. Goldwaser, Fabiano A. Gomes, Jody L. Greaney, Tomas Hajek, Susan L. McElroy, Roger S. McIntyre, Abigail Ortiz, Miguel L. Prieto, Elysha Ringin, Louisa G. Sylvia, Shang‐Ying Tsai, Jess G. Fiedorowicz, Benjamin I. Goldstein   +17 more
wiley   +1 more source

Emerging options for the management of age-related macular degeneration with stem cells

Stem Cells and Cloning: Advances and Applications, 2010
Ingrid Mooney1, James LaMotte21Eye Design, Santa Fe, NM, USA; 2Department of Basic and Visual Science, Southern California College of Optometry, Fullerton, CA, USAAbstract: Age-related macular degeneration (AMD) is a devastating retinal disease that ...
Ingrid Mooney, James LaMotte
doaj  

Activation of Type 4 Metabotropic Glutamate Receptor Regulates Proliferation and Neuronal Differentiation in a Cultured Rat Retinal Progenitor Cell Through the Suppression of the cAMP/PTEN/AKT Pathway. [PDF]

Front Mol Neurosci, 2020
Zhang Z, Liu Y, Luan Y, Zhu K, Hu B, Ma B, Chen L, Liu X, Lu H, Chen X, Liu Y, Zheng X.   +11 more
europepmc   +1 more source

Roles of ER Membrane Protein Complex in Protein Biogenesis and Quality Control in the Lung and Beyond

Cell Proliferation, Volume 59, Issue 6, June 2026.
The endoplasmic reticulum membrane protein complex (EMC) is an evolutionarily conserved, multi‐subunit transmembrane protein complex crucial to membrane protein biogenesis and cellular protein quality control. This review systematically examines the structure, functions and disease‐associated regulatory mechanisms of EMC across multiple organ systems ...
Yan Qiao, Yuqing Sun, Yutao Huang, Qinghang Meng, Xinhua Lin, Wei Wei, Xiaofang Tang   +6 more
wiley   +1 more source

Characterizing and influencing differentiation of Retinal Progenitor Cells

, 2018
vii CHAPTER 1. GENERAL INTRODUCTION INTRODCUTION 1 RETINAL DEVELOPMENT 1 ISOLATION AND EXPANSION OF NEURAL STEM CELLS 3 TRANSPLANTATION OF PROGENITOR CELLS 4 FACTORS THAT AFFECT DIFFERENTION OF RETINAL CELLS 7 EXPRESSION OF STRESS-RESPONSE PROTEINS 10 OXIDATIVE STRESS 13 PROTEOMICS 14 GENE ONTOLOGY 16 DISSERTATION ORGANIZATION 18 REFERENCES 18 CHAPTER ...
openaire   +3 more sources