Results 141 to 150 of about 24,391 (241)

A Dynamic Change of Microglial States Occurs During the Transition From Photoreceptor Degeneration to Regeneration in Zebrafish pde6c Mutants

Glia, Volume 74, Issue 6, June 2026.
Zebrafish pde6c mutants undergo photoreceptor degeneration from 5 dpf, but rods regenerate from 4 wpf. scRNA‐seq of retinal microglia reveals dynamic change of states between 5 dpf and 4 wpf. Two states emerge specifically during regeneration. ABSTRACT Microglia, brain‐resident immune cells, maintain brain homeostasis.
Darshini Ravishankar, Yuki Takeuchi, Ichiro Masai   +2 more
wiley   +1 more source

The Role of N6‐Methyladenosine Modification in Health and Disease

MedComm, Volume 7, Issue 6, June 2026.
N6‐methyladenosine (m6A) is the most prevalent internal RNA modification in eukaryotes, acting as a pivotal epitranscriptomic regulator of RNA metabolism. This modification plays a dual role: it maintains physiological homeostasis under normal conditions but drives disease progression when dysregulated.
Linghuan Li, Yuanhai Sun, Wanfang Zheng, Lingqin Li, Yaqian Feng, Minyou Qi, Hanbing Li   +6 more
wiley   +1 more source

Organoids: From Bench to Bedside Applications

MedComm, Volume 7, Issue 6, June 2026.
Organoids, as a groundbreaking biomedical research platform, utilize adult stem cells (ASCs), embryonic stem cells (ESCs), and induced pluripotent stem cells (iPSCs) as sources. By integrating specific growth and differentiation signals within an extracellular matrix (e.g., Matrigel), organoids guide cells to self‐assemble into three‐dimensional ...
Kelin Li, Rui Cao, Maochen Li, Zichao Tian, Huahao Fan, Bixia Hong, Xiaojuan Liu   +6 more
wiley   +1 more source

Retinal progenitor cell xenografts to the pig retina: immunological reactions

, 2006
We evaluated the host response to murine retinal progenitor cells (RPCs) following transplantation to the subretinal space (SRS) of the pig. RPCs from GFP mice were transplanted subretinally in 18 nonimmunosuppressed normal or laser-treated pigs ...
Warfvinge, Karin,, Klassen, Henry, Zamiri, Parisa, Young, Michael J, Prause, Jan U, Kiilgaard, Jens F, Streilein, Wayne, Scherfig, Erik, Lund University.   +8 more
core  

c-kit marks late retinal progenitor cells and regulates their differentiation in developing mouse retina

, 2007
Retinal progenitor cells are believed to display altered proliferation and differentiation during retinal development, suggesting that retinal progenitor cell populations are not homogeneous. However, the composition of progenitor cell populations is not
Watanabe, Sumiko, Koso, Hideto, Satoh, Shinya   +2 more
core   +1 more source

Pathways of Protein Secretion in Prokaryotes and Eukaryotes: Molecular Mechanisms, Biological Functions, and Therapeutic Opportunities

MedComm, Volume 7, Issue 6, June 2026.
This graphical abstract delineates noncanonical protein secretion systems across eukaryotes and prokaryotes. Eukaryotic UcPS covers four ER–Golgi bypass pathways, enabling rapid leaderless protein export via direct transmembrane translocation or vesicle‐mediated release.
Qiyuan Yang, Jingfei Shi, Linlin Xu, Guangrui Zhao, Yue Chen, Lin Cheng, Xiaokang Li, Zhigang Sun, Shuhong Huang   +8 more
wiley   +1 more source

Hyperglycemia-independent neonatal streptozotocin-induced retinopathy (NSIR) in rats

Frontiers in Pharmacology
Introduction: Chemicals, such as MNU (N-methyl-N-nitrosourea) and NaIO3 (sodium iodate), are widely used to induce retinal degeneration in rodents. Streptozotocin (STZ) is an analog of N-acetyl glucosamine in which an MNU moiety is linked to a hexose and
Yu Lin, Yu Lin, Wenyu Du, Wenyu Du, Xiangyu Fu, Xiangyu Fu, Ling Huang, Ling Huang, Yiwen Hong, Yiwen Hong, Haishan Tan, Haishan Tan, Lirong Xiao, Xiang Ren, Xiang Ren, Yujiao Wang, Yujiao Wang, Danian Chen, Danian Chen   +18 more
doaj   +1 more source

Studying In Vivo Retinal Progenitor Cell Proliferation in Xenopus laevis. [PDF]

Methods Mol Biol, 2020
Kha CX, Guerin DJ, Tseng KA.
europepmc   +1 more source

Diabetic Peripheral Neuropathy: Molecular Staging, Risk Factors, Therapeutics, and Emerging Trends

Med Research, Volume 2, Issue 2, Page 309-342, June 2026.
The heterogeneous landscape of DPN can be unified through a tripartite pathogenic model encompassing progressive stages of metabolic dysregulation, chronic inflammation, and overt neuronal damage. Within this framework, six clinical subtypes were identified, namely, hyperglycemia‐driven, dyslipidemia‐driven, inflammation‐driven, dysvascularity‐driven ...
Xiaofeng Dai, Mingze Tang
wiley   +1 more source

Induction of retinal progenitors and neurons from dental follicle stem cell under defined conditions

Journal of Dental Sciences
Background/purpose: Retinopathy affects millions worldwide with increasing prevalence. Dental-derived mesenchymal stem cells (MSCs), primarily originating from the neural crest, possess unique neural-like properties, including high expression of neural ...
Tzu-Pei Lee, Ming-Hua Ho, Yong-Ren Chen, Kuan-Ming Lin, Chung-Hsing Li   +4 more
doaj   +1 more source