Results 251 to 260 of about 48,633 (284)
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Expression of olig2 in retinal progenitor cells
NeuroReport, 2006Olig2 is a basic helix-loop-helix transcription factor that is specifically expressed in oligodendrocyte precursors in the central nervous system. Owing to the absence of oligodendrocytes in the retina, however, the role of olig2 in retinal development remains unclear.
Kazuaki, Nakamura +3 more
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Rat retinal progenitor cells and a retinal pigment epithelial factor
Developmental Brain Research, 2001Retinal progenitor cells were isolated from explants of neonatal rat retinas and characterized by transmission electron microscopy and reverse transcriptase-polymerase chain reaction and by their response to an isolated retinal pigment epithelial cell cell factor.
H J, Sheedlo +3 more
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Muller glia induce retinal progenitor cells to differentiate into retinal ganglion cells
NeuroReport, 2006Retinal progenitor cells could differentiate into various retinal cells that made cell-replacement therapy possible. Here, we investigated the role of cellular microenvironment on their regulation and differentiation and found that the percentage of proliferating cells and the percentage of retinal ganglion cells produced from them increased, when ...
Jing, Yao +3 more
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Retinal Progenitor Cells — Timing Is Everything
New England Journal of Medicine, 2007Permitting progenitor photoreceptor cells from donors to differentiate before transplanting them is key to their successful integration into the retina.
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Cytotherapy, 2011
Retinal progenitor cells (RPC) are an excellent resource for retinal replacement therapy but usually unavailable. We attempted to induce bone marrow mesenchymal stromal cells (BMSC) into RPC.BMSC and embryonic day 13.5 (E13.5) RPC derived from wild-type or enhanced green fluorescence protein (EGFP) transgenic (Egfp(+/+)) mice were co-cultured in a ...
Xuerong, Sun +9 more
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Retinal progenitor cells (RPC) are an excellent resource for retinal replacement therapy but usually unavailable. We attempted to induce bone marrow mesenchymal stromal cells (BMSC) into RPC.BMSC and embryonic day 13.5 (E13.5) RPC derived from wild-type or enhanced green fluorescence protein (EGFP) transgenic (Egfp(+/+)) mice were co-cultured in a ...
Xuerong, Sun +9 more
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Glutamate regulates retinal progenitors cells proliferation during development
European Journal of Neuroscience, 2006AbstractThe precise coordination of cell cycle exit and cell fate specification is essential for generating the correct proportion of retinal cell types during development. The decision to exit the cell cycle is regulated by intrinsic and extrinsic cues.
Rodrigo A P, Martins +2 more
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Influence of a retinal pigment epithelial cell factor(s) on rat retinal progenitor cells
Developmental Brain Research, 1996Retinal development was studied by explant culture of retinas from embryonic and neonatal rats in response to medium conditioned (CM) by a transformed neonatal rat retinal pigment epithelial (tnrRPE) cell line. Retinal explants from embryonic days 16 and 18 and postnatal day 2 Long-Evans rats were cultured for over 3 weeks on a poly-D,L-ornithine ...
H J, Sheedlo, J E, Turner
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Journal of Neuroscience Research, 1996
This study demonstrates the effects of conditioned media from transformed neonatal rat retinal pigment epithelial cells (tnrRPE-CM) in a culture system consisting of neonatal rat retinal explants. For this study, retinal explants from postnatal day 2 (PN2) normal rats were cultured for over 3 weeks on a poly-D-L-ornithine-coated surface in RPE-CM only,
H J, Sheedlo, J E, Turner
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This study demonstrates the effects of conditioned media from transformed neonatal rat retinal pigment epithelial cells (tnrRPE-CM) in a culture system consisting of neonatal rat retinal explants. For this study, retinal explants from postnatal day 2 (PN2) normal rats were cultured for over 3 weeks on a poly-D-L-ornithine-coated surface in RPE-CM only,
H J, Sheedlo, J E, Turner
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Cell-intrinsic regulators of proliferation in vertebrate retinal progenitors
Seminars in Cell & Developmental Biology, 2004The proliferative expansion of retinal progenitor cells (RPCs) is a fundamental mechanism of growth during vertebrate retinal development. Over the past couple of years, significant progress has been made in identifying genes expressed in RPCs that are essential for their proliferation, and the molecular mechanisms are beginning to be resolved. In this
Edward M, Levine, Eric S, Green
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Retinal Progenitor Cells, Differentiation, and Barriers to Cell Cycle Reentry
2010Neurogenesis in the retina occurs via the coordination of proliferation, cell cycle exit and differentiation of retinal progenitor cells. Until recently, it was widely assumed that once a retinal progenitor cell produced a postmitotic neuron, there was no possibility for cell-cycle re-entry. However, recent studies have shown that mature differentiated
Denise M, Davis, Michael A, Dyer
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